A5100435747- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal disorders and treatments
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Esophageal Cancer Research and Treatment
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Esophageal and GI Pathology
- Cancer-related molecular mechanisms research
- Gastrointestinal Tumor Research and Treatment
- Tracheal and airway disorders
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Helicobacter pylori-related gastroenterology studies
- Prostate Cancer Treatment and Research
- Circular RNAs in diseases
Second Military Medical University
2016-2025
Changhai Hospital
2016-2025
Sichuan University
2008-2025
West China Hospital of Sichuan University
2008-2025
Nanjing University
2015-2025
Nanjing General Hospital of Nanjing Military Command
2023-2025
Nanjing Drum Tower Hospital
2015-2024
Xuzhou Medical College
2014-2024
Zhongda Hospital Southeast University
2024
People's Hospital of Xinjiang Uygur Autonomous Region
2014-2024
Pulmonary endothelium is an active organ possessing numerous physiological, immunological, and metabolic functions. These functions may be altered early in acute lung injury (ALI) further contribute to the development of respiratory distress syndrome (ARDS). strategically located filter entire blood before it enters systemic circulation; consequently its integrity essential for maintenance adequate homeostasis both pulmonary circulations. Noxious agents that affect induce alterations...
The RET fusion gene has been recently described in a subset of non-small-cell lung cancers (NSCLCs). Because we have limited knowledge about these tumors, this study was aimed at determining the clinicopathologic characteristics patients with NSCLC harboring gene.We examined 936 surgically resected using reverse transcriptase polymerase chain reaction (PCR) plus quantitative real-time PCR strategy, validation immunohistochemical and fluorescent situ hybridization assays. A 633...
The clinicopathologic characteristics of tumors expressing programmed death (PD-1) ligands (PD-Ls) PD-L1 or PD-L2 and their associations with common driver mutations in lung adenocarcinoma are not clearly defined, despite the progression anti-PD-1/PD-L1 immunotherapy.PD-L1 expression was measured by immunohistochemistry 143 surgically resected adenocarcinomas correlated clinical variables, histologic subtypes, mutational status EGFR, KRAS, HER2, ALK.Positive significantly associated more...
Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease refractory to all targeted and immune therapies. However, our understanding of PDAC microenvironment especially the very limited partly due inaccessibility tumor tissues. Here, we present single-cell transcriptomic landscape synchronously resected primary tumors matched liver metastases. We perform comparative analysis on both cellular composition functional phenotype between tumors. Tumor cells exhibit distinct profile...
Amcenestrant (oral selective estrogen receptor degrader) demonstrated promising safety and efficacy in earlier clinical studies for endocrine-resistant, receptor-positive/human epidermal growth factor 2-negative (ER+/HER2-) advanced breast cancer (aBC).
Abstract Recurrent gene fusions between the androgen-regulated TMPRSS2 and ETS transcription factor family members ERG, ETV1, ETV4 have been identified as a critical event in prostate cancer development. In this study, we characterized prevalence diversity of these rearrangements hormone-refractory metastatic cancer. We used fluorescence situ hybridization (FISH) split probe strategy to comprehensively evaluate TMPRSS2-ETS aberrations across 97 nonosseous sites from 30 rapid autopsies men...
Abstract Recurrent gene fusions between the androgen-regulated TMPRSS2 and ETS family transcription factors ERG, ETV1, ETV4 have been identified in majority of prostate adenocarcinomas (PCA). PCA is often multifocal with histologic heterogeneity different tumor foci. As a common 5′ partner fusions, we monitored rearrangement by fluorescence situ hybridization (FISH) to study origin molecular basis heterogeneity. was evaluated FISH on tissue microarray representing 93 PCAs from 43 radical...
Our previous study revealed that 90% [47 of 52; 95% confidence interval (CI), 0.79-0.96] Chinese never-smokers with lung adenocarcinoma harbor known oncogenic driver mutations in just four genes EGFR, ALK, HER2, and KRAS. Here, we examined the status specifically female adenocarcinoma.Tumors were genotyped for KRAS, BRAF. Data on age, stage, tumor differentiation, histologic subtypes, molecular alterations recorded from 349 resected adenocarcinomas never-smokers. We further compared...
Colonoscopy remains the standard screening method for detecting colorectal cancer (CRC) at an early stage. However, many people avoid having a colonoscopy because of fear its potential complications. Our study aimed to identify plasma microRNAs preliminarily CRC in general population, so that some unnecessary colonoscopies can be avoided. We investigated microRNA expression three independent cohorts including discovery (n = 80), training 112), and validation 49) phases recruited two medical...
Neoadjuvant chemotherapy (NCT) is a standard treatment option for locally advanced breast cancer. However, the lack of an efficient method to predict response and patient prognosis hampers clinical evaluation eligibility NCT. An elevated lymphocyte-to-monocyte ratio (LMR) has been reported be associated with favorable certain hematologic malignancies nasopharyngeal carcinoma; however, this association not investigated in The purpose study was evaluate whether pre-NCT LMR analysis could...
Objectives: Rare pathogenic variants in the SPINK1, PRSS1, CTRC, and CFTR genes have been strongly associated with a risk of developing chronic pancreatitis (CP). However, their potential impact on age disease onset clinical outcomes, as well interactions environmental factors, remain unclear. These issues are addressed here large Chinese CP cohort. Methods: We performed targeted next-generation sequencing four CP-associated 1061 Han patients 1196 controls. To evaluate gene-environment...
<h3>Importance</h3> Most early lung cancers present as pulmonary nodules on imaging, but these can be easily missed chest radiographs. <h3>Objective</h3> To assess if a novel artificial intelligence (AI) algorithm help detect radiographs at different levels of detection difficulty. <h3>Design, Setting, and Participants</h3> This diagnostic study included 100 posteroanterior radiograph images taken between 2000 2010 adult patients from an ambulatory health care center in Germany image...
This study sought to characterize racial and ethnic disparities in cervical cancer screening follow-up of abnormal findings across 3 U.S. healthcare settings.
Abstract Background Pancreatic adenocarcinoma (PC) is an aggressive malignancy with limited treatment options. The poor prognosis primarily stems from late-stage diagnosis and when the disease has become therapeutically challenging. There urgent need to identify specific biomarkers for cancer subtyping early detection enhance both morbidity mortality outcomes. addition of EGFR tyrosine kinase inhibitor (TKI), erlotinib, gemcitabine chemotherapy first-line patients advanced pancreatic...
Abstract Integrative analysis of genomic aberrations in the context trancriptomic alterations will lead to a more comprehensive perspective on prostate cancer progression. Genome-wide copy number changes were monitored using array comparative hybridization laser-capture microdissected samples spanning stages progression, including precursor lesions, clinically localized disease, and metastatic disease. A total 62 specific cell populations from 38 patients profiled. Minimal common regions...
Background Atypical cribriform lesions (ACLs) of the prostate consist glands lined with cytologically malignant cells partial or complete basal cell lining. It may represent “high-grade prostatic intraepithelial neoplasia” (HGPIN) “intraductal carcinoma prostate” (IDC-P), which is almost always associated clinically aggressive (PCa). Distinction between these 2 has profound clinical significance, especially on needle biopsies. However, there are that do not fully satisfy criteria for IDC-P...
Inspired by the natural product evodiamine, a novel antitumor indolopyrazinoquinazolinone scaffold was designed hopping. Structure-activity relationship studies led to discovery of compound 15j, which shows low nanomolar inhibitory activity against HCT116 cell line. Further mechanism indicated that 15j acted dual inhibition topoisomerase 1 and tubulin induced apoptosis with G2 cell-cycle arrest. The quaternary ammonium salt (compound 15js) exhibited excellent in vivo (TGI = 66.6%) xenograft...
BACKGROUND Latinas have the highest rates of cervical cancer in United States and second rate mortality. One factor disparity is relatively low screening for this population. METHODS Eligible women who were out adherence with (>3 years since their last Papanicolaou [Pap] test) identified via medical record review by a federally qualified local health center. The effects low‐intensity intervention (video delivered to participants' homes; n = 150) high‐intensity plus home‐based educational...
BackgroundWe aimed to develop a deep learning-based segmentation system for rapid on-site cytopathology evaluation (ROSE) improve the diagnostic efficiency of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) biopsy.MethodsA retrospective, multicenter, study was conducted using 5345 cytopathological slide images from 194 patients who underwent EUS-FNA. These were Nanjing Drum Tower Hospital (109 patients), Wuxi People's (30 Second (25 and The Affiliated Soochow University...