A5101944199- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Stroke Rehabilitation and Recovery
- Neuroendocrine Tumor Research Advances
- Cancer Cells and Metastasis
- Family and Patient Care in Intensive Care Units
- Radiomics and Machine Learning in Medical Imaging
- Palliative Care and End-of-Life Issues
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- AI in cancer detection
- Genetic factors in colorectal cancer
- Intensive Care Unit Cognitive Disorders
- Gastrointestinal disorders and treatments
- Liver Disease and Transplantation
- Colorectal Cancer Screening and Detection
- Organ Transplantation Techniques and Outcomes
- Metastasis and carcinoma case studies
- Corneal Surgery and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Affiliated Hospital of Hebei University
2024
Nanjing Drum Tower Hospital
2014-2024
Yueqing People's Hospital
2024
Nanjing University
2024
Affiliated Hospital of Guizhou Medical University
2022
Guiyang Medical University
2022
University of South China
2022
Nanjing University of Chinese Medicine
2022
Nanfang Hospital
2012-2022
BackgroundWe aimed to develop a deep learning-based segmentation system for rapid on-site cytopathology evaluation (ROSE) improve the diagnostic efficiency of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) biopsy.MethodsA retrospective, multicenter, study was conducted using 5345 cytopathological slide images from 194 patients who underwent EUS-FNA. These were Nanjing Drum Tower Hospital (109 patients), Wuxi People's (30 Second (25 and The Affiliated Soochow University...
Importance Diagnosing solid lesions in the pancreas via endoscopic ultrasonographic (EUS) images is challenging. Artificial intelligence (AI) has potential to help with such diagnosis, but existing AI models focus solely on a single modality. Objective To advance clinical diagnosis of through developing multimodal model integrating both information and EUS images. Design, Setting, Participants In this randomized crossover trial conducted from January 1 June 30, 2023, 4 centers across China,...
Background: The aldehyde dehydrogenase 1 family member A3 (ALDH1A3) is a key enzyme associated with variety of metabolic processes, including glucose metabolism. We recently uncovered that metabolism played an essential role in promoting metastasis pancreatic ductal adenocarcinoma (PDAC). As ALDH1A3 labels aggressive subtype PDAC, we hypothesized functionally promoted PDAC via its effect on Methods: Expression was detected human tissues by immunohistochemistry. knocked down or overexpressed...
We present a modified endoscopic hand-suturing (EHS) technique that effectively and safely closed an ileocecal defect following submucosal dissection (ESD) without requiring reinsertion of the endoscope. A 59-year-old woman underwent ESD for laterally spreading tumor measuring approximately 3.5 × 3.0 cm in ileocecum. The steps EHS procedure are detailed below ([Video 1Video 1]).
Background and Objectives: Pancreatic cystic neoplasms (PCNs) are being increasingly identified. Recent reports have described the utility of endoscopic ultrasound (EUS) in characterization PCNs. This study presents diagnostic value EUS Materials Methods: A total 108 patients (78 women 30 men; average age, 50 years) who were confirmed pathologically to PCNs analyzed retrospectively. We clinical characteristics compared performance computed tomography (CT), magnetic resonance imaging (MRI),...
Abstract Background and Aim Endoscopic ultrasound‐guided fine needle aspiration (EUS‐FNA) is the most established diagnostic method for pancreatic tissue. Rapid on‐site evaluation by a trained endoscopist (self‐ROSE) can improve accuracy. This research aimed to analyze application value of self‐ROSE EUS‐FNA in solid lesions. Methods A total 194 consecutive patients with lesions Nanjing Drum Tower Hospital were randomized 1:1 ratio or without this single‐center controlled trial. Before...
To understand the status quo of multiprofessional and multidisciplinary collaboration for early mobilization mechanically ventilated patients in Chinese ICUs identify any factors that may influence this practice. A multi-centre cross-sectional survey. From October to November 2022, convenience sampling method was used select ICU mobility members (including physicians, nurses physiotherapists) from 27 tertiary general hospitals 14 provinces, cities autonomous regions China. They were asked...
Mesenchymal stem cells (MSCs) have been reported to promote long-term cellular and organ transplant acceptance due their immunotherapeutic characteristics. Previous work from our lab using a rat allograft model has shown that systemic infusion of MSCs inhibited corneal rejection prolonged graft survival. Here, we further investigated the effects local administration in same animal model. Donor-derived were isolated cultured while grafts obtained Wistar rats transplanted into Lewis hosts....
Circulating tumor cells (CTCs) were a promising liquid biopsy for pancreatic cancer (PC) but circulate in low counts peripheral blood. We evaluated the diagnostic and prognostic values of portal vein (PoV) CTCs PC patients.PoV was aspirated under EUS guidance from 40 patients with suspected pancreaticobiliary cancers. Epithelial-mesenchymal-transition-related subtypes identified via immunofluorescence using EpCAM Twist antibodies. The performance PoV investigated by receiver-operating...
To evaluate the regulation mechanism of heat shock protein 27 (HSP27) on gemcitabine (GEM) resistance pancreatic cancer cell.The expression vectors pEGFP-C1-HSP27 and MicroRNA targeting Snail were introduced into GEM-sensitive SW1990 cells, small hairpin RNA HSP27 transfected GEM-resistant SW1990/GEM cells. The expressions HSP27, p-HSP27 (Ser82), Snail, ERCC1, E-cadherin evaluated by Western blotting. sensitivity cells to GEM was detected CCK-8 assay Annexin V-FITC apoptosis assay.As...
Objective We aimed to evaluate the efficacy of endoscopic ultrasonography (EUS) in assessing locoregionally and determining therapeutic options for ampullary adenomas related factors. Methods Patients undergoing EUS surgical or resection biopsy‐proven between 2009 2016 were retrospectively analyzed. The depth tumor invasion, intraductal extension, regional lymph node staging evaluated by compared with post‐treatment pathological findings. Results Altogether 120 patients enrolled this study....
Abstract Background and aims In recent years, with the development of endoscopic techniques, resection is widely used for duodenal papillary adenomas, but conventional has a high rate incomplete recurrence. On this basis, we have employed novel modified papillectomy (ESP). study, evaluated feasibility advantages ESP treatment major papilla adenoma. Methods A total 56 patients adenoma confirmed by ultrasonography, intraluminal ultrasound gastroscopic biopsy from October 2007 to June 2017 were...
Objective To explore the diagnostic value of endoscopic ultrasound‐guided fine needle aspiration (EUS‐FNA) for small, solid or semi‐solid pancreatic lesions (≤20 mm) and factors affecting its accuracy. Methods Altogether 92 patients with who underwent EUS‐FNA at Nanjing Drum Tower Hospital from November 2009 to January 2019 were retrospectively analyzed. Univariate multivariate analyses used determine accuracy detecting these lesions. Results Among cases, 56 (60.9%) diagnosed as having...
Pancreatic cancer (PC) has been the fourth cancer-related death worldwide, diagnosed at an unresectable stage due to its rapid progression and few symptoms of this disease early stages. The aim study was determine association between diversity T-cell receptor (TCR) repertoire clinicopathological characteristics patients with PC other benign pancreatic diseases. In order make a comprehensive analysis TCR repertoire, high-throughput sequencing used differentiate complementarity determining...
Background There are no long-term (>10 years) follow-up evaluations of the effects handstand exercise or studies on use equipment for passive exercise. Objective To report a 40-year investigation Chinese man who has been practicing 40 years. Design This observational was conducted in Guizhou Province, China. Participant A (currently) 66-year-old had years followed up. Interventions Physical and auxiliary examinations were carried out to determine human body. Main Measures The...
We present a modified endoscopic hand-suturing (EHS) technique that effectively and safely closed an ileocecal defect following submucosal dissection (ESD) without requiring reinsertion of the endoscope. A 59-year-old woman underwent ESD for laterally spreading tumor measuring approximately 3.5 × 3.0 cm in ileocecum. The steps EHS procedure are detailed below ([Video 1]).
Lipotoxicity has been shown to induce the loss of functional β-cell mass and lead type 2 diabetes, but mechanism remains unknown. In this study, we aim explore role secretagogin (SCGN) in lipotoxicity-induced injury. Our results indicate that ox-LDL treatment leads autophagic cell death, as evidenced by decreased viability, aggravated apoptosis, accumulation p62 protein MIN6 cells. LysoTracker Red staining, TEM mRFP-GFP-LC3 assays demonstrate flux is blocked ox-LDL-treated Intriguingly, SCGN...