A5083149235- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Hepatitis B Virus Studies
- Cancer-related molecular mechanisms research
- Liver physiology and pathology
- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- DNA Repair Mechanisms
- Neuroendocrine Tumor Research Advances
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Autophagy in Disease and Therapy
- Liver Disease Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Inflammatory Biomarkers in Disease Prognosis
- Pancreatitis Pathology and Treatment
- Inflammasome and immune disorders
- Cancer-related gene regulation
- Lung Cancer Research Studies
- Circular RNAs in diseases
Huazhong University of Science and Technology
2016-2025
Tongji Hospital
2016-2025
Sun Yat-sen University
2013-2025
Hospital of Stomatology, Sun Yat-sen University
2022-2025
Kunming Medical University
2023
Yangzhou University
2023
XinHua Hospital
2023
Shanghai Ninth People's Hospital
2023
Shanghai Jiao Tong University
2022-2023
Stomatology Hospital
2023
Abstract Increasing evidence supports that ferroptosis plays an important role in tumor growth inhibition. Sorafenib, originally identified as inhibitor of multiple oncogenic kinases, has been shown to induce hepatocellular carcinoma (HCC). However, some hepatoma cell lines are less sensitive sorafenib-induced ferroptotic death. Glutathione S-transferase zeta 1 (GSTZ1), enzyme the catabolism phenylalanine, suppresses expression master regulator cellular redox homeostasis nuclear factor...
Human hepatocellular carcinoma (HCC) is driven and maintained by liver cancer stem cells (LCSCs) that display cell properties. These LCSCs are promoted the intersecting of Notch Wnt/β-Catenin signaling pathways. In this study, we demonstrate with markers CD90, CD24, CD13, CD133 possess properties self-renewal tumorigenicity in NOD/SCID mice. The increased expression these was correlated advanced disease stage, larger tumors, worse overall survival 61 HCC cases. We also found both...
The inducible nitric oxide synthase (iNOS) is associated with more aggressive solid tumors, including hepatocellular carcinoma (HCC). Notch signaling in cancer stem cells promotes progression and requires cleavage by ADAM (a disintegrin metalloprotease) proteases. We hypothesized that iNOS/NO Notch1 activation through TACE/ADAM17 liver (LCSCs), leading to a phenotype. Expression of the cell markers CD24 CD133 tumors patients HCC was greater iNOS expression worse outcomes. CD24+CD133+ LCSCs,...
Abstract Early metastasis is the primary factor in very poor prognosis of pancreatic ductal adenocarcinoma (PDAC), with liver being most common form distant PDAC. To investigate mechanism PDAC metastasis, we found that cells can promote formation pre-metastatic niches (PMNs) through exosomes to facilitate early stage. In our study, hepatic stellate (HSCs) were treated PDAC-derived (PDAC-exo), and activation HSCs was detected. A novel transfer RNA-derived fragment, tRF-GluCTC-0005 obtained by...
Importance Diagnosing solid lesions in the pancreas via endoscopic ultrasonographic (EUS) images is challenging. Artificial intelligence (AI) has potential to help with such diagnosis, but existing AI models focus solely on a single modality. Objective To advance clinical diagnosis of through developing multimodal model integrating both information and EUS images. Design, Setting, Participants In this randomized crossover trial conducted from January 1 June 30, 2023, 4 centers across China,...
Accumulation of genetic alterations in hepatocarcinogenesis is closely associated with chronic inflammatory liver disease. 8-oxo-2′-deoxyguanosine (8-oxo-dG), the major promutagenic DNA adduct caused by reactive oxygen species (ROS), leads to G:C → T:A transversions. These lesions can be enzymatically repaired mainly human MutT homolog 1 (hMTH1), 8-oxo-guanine glycosylase (hOGG1) and MutY (hMYH). The aim this study was evaluate extent oxidative damage its dependence on cellular antioxidative...
CD90 has been identified as a marker for liver cancer stem cells (CSCs) that are responsible tumorigenic activity, but it is not known how CD90+ contribute to tumor initiation and progression. Our data demonstrated high expression of in Hepatocellular Carcinoma (HCC) tissues correlated with venous filtration HCC patients. isolated from cell lines exhibited increased tumorigenicity, chemoresistance, invasion metastasis. Notch pathway was activated we found inhibition CSCs decreased invasion,...
Abstract Background Liver cancer stem cells (LCSCs) contribute to hepatocellular carcinoma (HCC) development, metastasis, and drug resistance. MSI2 Notch1 signaling are involved in the maintenance of CSCs. However, it is unknown whether CD44v6+ LCSCs. Therefore, we investigated clinical significance function its relationship with stemness properties Methods The expression CD44v6 were detected by fresh specimens a HCC tissue microarray. microarray containing 82 samples was used analyze...
HBV infection has been reported to trigger endoplasmic reticulum (ER) stress and initiate autophagy. However, how ER autophagy influence production remains elusive. Here, we studied the effect of tunicamycin (TM), an N-glycosylation inhibitor inducer, on replication secretion examined underlying mechanisms.Protein disulfide isomerase (an marker), microtubule-associated protein 1 light chain 3 beta autophagosome [AP] sequestosome-1 (a typical cargo for autophagic degradation) expression were...
Exosomes act as essential modulators of cancer development and progression in hepatocellular carcinoma. However, little is known about the potential prognostic value underlying molecular features exosome-related long non-coding RNAs.Genes associated with exosome biogenesis, secretion, biomarkers were collected. Exosome-related lncRNA modules identified using PCA WGCNA analysis. A model based on data from TCGA, GEO, NODE, ArrayExpress was developed validated. comprehensive analysis genomic...
Owing to the lack of effective treatment options, early metastasis remains major cause pancreatic ductal adenocarcinoma (PDAC) recurrence and mortality. However, molecular mechanism is largely unknown. We characterized function eukaryotic translation initiation factors (eIFs) in epithelial-mesenchymal-transition (EMT) cancer cells investigate whether eIFs downstream c-MYC affect EMT by joint interference.We used The Cancer Genome Atlas (TCGA) Tissue Expression (GTEx) databases analyze eIF4A1...
Abstract Background Cancer-associated fibroblasts (CAFs), an important component of the tumor microenvironment (TME), play crucial roles in stemness. It has been shown various cancer studies that stanniocalcin-1 (STC1) is secreted by CAFs, however, its function HCC still not clear. Methods The serum concentration and intracellular expression level STC1 were quantified ELISA western blotting, respectively. role CAF-derived stemness was investigated sphere formation, sorafenib resistance,...
Liquid-liquid phase separation (LLPS) enhances oncogenic signaling pathways and advances cancer progression, has been proposed as a promising biomarker intervention target. Nevertheless, doubts remain about the prognostic importance of LLPS-related long non-coding RNAs (lncRNAs) in hepatocellular carcinoma (HCC). Methods: An lncRNA signature was generated by drivers regulators LLPS, validated external datasets. The underlying genetic changes functional enrichment were assessed. drug...
Abstract Emerging evidence shows that lipid metabolic reprogramming plays a vital role in tumor metastasis. The effect and mechanism of fatty acids droplets (LDs), the core products metabolism, on metastasis oral squamous cell carcinoma (OSCC), need further exploration. In this study, influence palmitic acid (PA) oleic (OA) migration invasion ability OSCC cells was determined by vitro experiments. Genetic manipulation PLIN2 performed to explore its accumulation LDs Possible mechanisms these...
ABSTRACT Intratumoral brachytherapy enables higher dose treatment and reduces damage to adjacent tissues. We first validated the feasibility safety of endoscopic ultrasound (EUS)‐guided Yttrium‐90 ( 90 Y) microspheres implantation in a porcine model. Under EUS guidance, Y‐loaded were implanted into pancreas 10 miniature pigs. The pig was with MBq particles. Subsequently, nine pigs sequentially included low‐ (20 MBq), medium‐ (40 high‐dose (60 MBq) groups. Positron emission tomography...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by cancer cells surrounded affluent stromal components, which may underlie their limited response to various therapeutic interventions, including immunotherapy. Inflammatory cancer‐associated fibroblasts (iCAFs), a crucial subset of CAFs within the PDAC microenvironment, play pivotal role in shaping an immunosuppressive microenvironment. In this study, single‐cell RNA sequencing analysis performed screen for cells‐secreted...