A5044484875- Liver Diseases and Immunity
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Drug Transport and Resistance Mechanisms
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Drug-Induced Hepatotoxicity and Protection
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Diverticular Disease and Complications
- Gastrointestinal disorders and treatments
- Pharmaceutical Practices and Patient Outcomes
- Urinary and Genital Oncology Studies
- Hepatitis Viruses Studies and Epidemiology
- Metabolism and Genetic Disorders
- Hepatitis B Virus Studies
- Multiple Sclerosis Research Studies
- Congenital Heart Disease Studies
- Health Promotion and Cardiovascular Prevention
- Alcohol Consumption and Health Effects
- Amino Acid Enzymes and Metabolism
- Clinical Nutrition and Gastroenterology
- Medical Imaging and Pathology Studies
- Potassium and Related Disorders
- Digestive system and related health
University of Zurich
2020-2024
Saarland University
2013-2023
University Hospital of Zurich
2007-2023
German Liver Foundation
2019
Universitätsklinikum des Saarlandes
2011-2017
University of Bonn
2004-2007
University Hospital Bonn
2006
Max Planck Institute of Biochemistry
2004
Little is known about cholestasis, including its most severe variant secondary sclerosing cholangitis (SSC), in critically ill patients with coronavirus disease 19 (COVID-19). In this study, we analysed the occurrence of cholestatic liver injury and SSC, clinical, serological, radiological histopathological findings.We conducted a retrospective single-centre analysis all consecutive admitted to intensive care unit (ICU) as result COVID-19 at University Hospital Zurich describe these...
Accumulation of genetic alterations in hepatocarcinogenesis is closely associated with chronic inflammatory liver disease. 8-oxo-2′-deoxyguanosine (8-oxo-dG), the major promutagenic DNA adduct caused by reactive oxygen species (ROS), leads to G:C → T:A transversions. These lesions can be enzymatically repaired mainly human MutT homolog 1 (hMTH1), 8-oxo-guanine glycosylase (hOGG1) and MutY (hMYH). The aim this study was evaluate extent oxidative damage its dependence on cellular antioxidative...
<i>Background/Aims:</i> Pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, has been shown to inhibit growth and induce apoptosis in human hepatocellular carcinoma (HCC) cells. However, the potential benefit of pravastatin HCC patients still not characterized, which prompted us test efficacy with advanced HCC. <i>Methods:</i> We investigated prospectively cohort 183 who had selected for palliative treatment by transarterial chemoembolization...
Genetic variants in the adenosine triphosphate‐binding cassette subfamily B member 4 ( ABCB4 ) gene, which encodes hepatocanalicular phosphatidylcholine floppase, can lead to different phenotypes, such as progressive familial intrahepatic cholestasis (PFIC) type 3, low phospholipid‐associated cholelithiasis, and of pregnancy. The aim this multicenter project was collect information on onset progression entity age groups assess relevance disease for differential diagnosis chronic liver...
Poor adherence to medication leads worsening of the disease, increased mortality and substantial rise in health care costs.It was our aim evaluate drug influencing factors a cohort non-selected adult pharmacy customers with various chronic diseases following long-term treatment.We conducted an 8 week anonymized survey 152 German pharmacies using Morisky Medication Adherence Scale measure questionnaire comprising questions on multiple potential impact adherence. Depression assessed applying...
A higher-than-usual resistance to standard sedation regimens in COVID-19 patients suffering from acute respiratory distress syndrome (ARDS) has led the frequent use of second-line anaesthetic agent ketamine. Simultaneously, an increased incidence cholangiopathies mechanically ventilated receiving prolonged infusion high-dose ketamine been noted. Therefore, objective this study was investigate a potential dose-response relationship between and bilirubin levels.Post hoc analysis prospective...
Objective Rare variants in certain transcription factors involved cardiac development cause Mendelian forms of congenital heart disease. The purpose this study was to systematically assess the frequency rare factor sporadic patients with outflow tract malformation tetralogy Fallot (TOF). Methods and Results We sequenced coding, 5′UTR, 3′UTR regions twelve genes implicated (NKX2.5, GATA4, ISL1, TBX20, MEF2C, BOP/SMYD1, HAND2, FOXC1, FOXC2, FOXH, FOXA2 TBX1) 93 non-syndromic, non-Mendelian TOF...
Colonic diverticulosis is one of the most common gastroenterological disorders. Although typically benign, many individuals develop diverticulitis or other aspects diverticular disease. Diverticulosis thought to stem from a complex interaction environmental, dietary, and genetic factors; however, contributing factors remain unknown.The aim our present study was determine role variants within genes encoding for collagens connective tissue in diverticulosis.This transsectional association...
Abstract Background Despite emerging reports of secondary sclerosing cholangitis (SSC) in critically ill COVID-19 patients little is known about its imaging findings. It presents as delayed progressive cholestatic liver injury with risk progression to cirrhosis. Diagnosis cannot be made based on clinical presentation and laboratory markers alone. Magnetic resonance (MRI) magnetic cholangiopancreatography (MRCP) can aid the diagnosis. The aim this study was describe MRI/MRCP features...
<i>Background/Aims:</i> To evaluate the long-term outcome of surgical and non-surgical local treatments patients with hepatocellular carcinoma (HCC). <i>Methods:</i> We stratified a cohort 278 HCC using six independent predictors survival according to Vienna model for (VISUM-HCC). <i>Results:</i> Prior therapy, 224 presented VISUM stage 1 (median 18 months) while 29 were classified as 2 4 25 3 months). A highly significant (p < 0.001) improved time was...
Staging of liver fibrosis traditionally relied on histology; however, transient elastography (TE) and more recently two-dimensional shear wave (2D-SWE) evolved to noninvasive alternatives. Hence, we evaluated the diagnostic accuracy 2D-SWE assessed by Canon Aplio i800 ultrasound system using biopsy as reference compared performance TE.In total, 108 adult patients with chronic disease undergoing biopsy, TE were enrolled prospectively at University Hospital Zurich. Diagnostic accuracies area...
Abstract Purpose To compare the diagnostic performance of T1 mapping and MR elastography (MRE) for staging hepatic fibrosis grading inflammation with histopathology as standard reference. Methods 68 patients various liver diseases undergoing biopsy suspected or an established diagnosis cirrhosis prospectively underwent look-locker inversion recovery MRE. relaxation time stiffness (LS) were measured by two readers. Hepatic histopathologically staged according to a standardized (F0–F4) (A0–A2)...
Organic anion transporters (OATs) are exchangers that transport small hydrophilic anions and diuretics, antibiotics, nonsteroidal anti-inflammatory drugs, antiviral nucleoside analogs, antitumor drugs across membrane barriers of epithelia diverse organs. Three OATs present in human liver: OAT2, OAT5, OAT7. Given hepatocyte nuclear factor-1α (HNF-1α) has previously been shown to regulate the expression several hepatocellular transporter genes, we investigated whether liver-specific OAT genes...
ABSTRACT Background Recently it has been postulated that gallbladder mucin hypersecretion observed in the pathogenesis of cholesterol gallstone disease may be induced by biliary lipid peroxidation. Ursodeoxycholic acid treatment reduces concentration and formation crystals bile patients with gallstones this effect might mediated a decrease Material methods In double‐blind, placebo‐controlled trial symptomatic received either ursodeoxycholic (750 mg daily) ( n = 10) or placebo 12) 10–12 days...
Hepatic metastases are common in the clinical course of breast cancer and typically appear as mass lesions. This report describes case a 70-year-old woman with history no previously known liver disease presenting first episode variceal bleeding subacute hepatic failure. Imaging studies indicated cirrhosis without signs malignant focal Comprehensive diagnostic work-up was negative for specific causes provided evidence tumor recurrence. Finally transjugular biopsy revealed marked diffuse...
Abstract Background Chronic inflammation of the gallbladder wall and mucin hypersecretion are considered to be important factors in pathogenesis cholesterol gallstone disease. The aim study was compare concentration secretagogue activity with lipid peroxidation bile patients or pigment stones. Material methods We studied and, as a marker peroxidation, malondialdehyde 11 rapid (1 3 days) eight non‐nucleating (> 21 biles Furthermore, biles, well 1–5 µmol L −1 on cultured epithelial cells,...
Fontan-associated liver disease is an increasing concern. Our aim was to assess prevalence and predictors of advanced fibrosis with a specific focus on utility stiffness measurement by ultrasound transient elastography.A total 97 adult Fontan patients (55% male, median age: 23.1 years, interquartile range [IQR]: 18.7-30.6); 92 (95%) were evaluated elastography, 50 (52%) underwent transjugular biopsy. Advanced defined as congestive hepatic score 3 or 4.Only 4 (4%) had values < 10 kilopascal...
Abstract Colonic diverticulosis is a very common condition. Many patients develop diverticulitis or other complications of diverticular disease. Recent genome-wide association studies (GWAS) consistently identified three major genetic susceptibility factors for both conditions, but did not discriminate diverticulititis and in particular due the limitations registry-based approaches. Here, we aimed to confirm role variants diverticulitis, respectively, within well-phenotyped cohort who...
1Department of Medicine IISaarland University Medical CenterHomburgGermany 2Institute PathologySaarland University, Saarland *ADDRESS CORRESPONDENCE AND REPRINT REQUESTS TO:Christoph Jüngst, M.D.,Department II Center Kirrbergerstr. 10066421 Homburg, GermanyE‐mail: [email protected]Tel: +0049‐6841‐1623223
<i>Background/Aims:</i> Ursodeoxycholic acid (UDCA) decreases biliary secretion of cholesterol and is therefore used for the dissolution gallstones. It remains unclear whether these changes in excretion are associated with synthesis bile synthesis. We studied activities rate-limiting enzymes synthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase 7α-hydroxylase, respectively, normal subjects during UDCA feeding. <i>Methods:</i> was given to 8 healthy volunteers (5...