A5035439262- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiation Dose and Imaging
- Radiomics and Machine Learning in Medical Imaging
- Advanced X-ray and CT Imaging
- Spinal Fractures and Fixation Techniques
- Pancreatic and Hepatic Oncology Research
- Management of metastatic bone disease
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Medical Imaging Techniques and Applications
- Renal cell carcinoma treatment
- Spine and Intervertebral Disc Pathology
- Radiology practices and education
- Advanced Radiotherapy Techniques
- Gallbladder and Bile Duct Disorders
- Pelvic and Acetabular Injuries
- Cardiac Valve Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Medical Image Segmentation Techniques
- Pancreatitis Pathology and Treatment
- Abdominal vascular conditions and treatments
- Medical Imaging and Pathology Studies
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
Technische Universität Dresden
2015-2025
University Hospital Carl Gustav Carus
2014-2025
Carl Gustav Carus-Institut
2024-2025
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2012-2023
German Cancer Research Center
2020-2022
Heidelberg University
2008-2022
Helmholtz-Zentrum Dresden-Rossendorf
2022
Berufsverband der Deutschen Dermatologen
2020-2022
National Center for Tumor Diseases
2021-2022
European Society of Radiology
2022
In patients with acute pulmonary embolism, systemic thrombolysis improves right ventricular (RV) dilatation, is associated major bleeding, and withheld in many at risk. This multicenter randomized, controlled trial investigated whether ultrasound-assisted catheter-directed (USAT) superior to anticoagulation alone the reversal of RV dilatation intermediate-risk patients. Fifty-nine (63±14 years) main or lower lobe embolism echocardiographic left dimension (RV/LV) ratio ≥1.0 were randomized...
Abstract Background: Updated National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for the use tumor markers in clinic have been developed. Methods: Published reports relevant to 4 cancer sites—liver, bladder, cervical, and gastric—were critically reviewed. Results: α-Fetoprotein (AFP) may be used conjunction with abdominal ultrasound early detection hepatocellular carcinoma (HCC) patients chronic hepatitis or cirrhosis associated B C virus infection. AFP...
To compare selective internal radiation therapy (SIRT) with transarterial chemoembolization (TACE), the standard-of-care for intermediate-stage unresectable, hepatocellular carcinoma (HCC), as first-line treatment.SIRTACE was an open-label multicenter randomized-controlled pilot study, which prospectively compared primarily safety and health-related quality of life (HRQoL) changes following TACE SIRT. Patients unresectable HCC, Child-Pugh ≤B7, ECOG performance status ≤2 ≤5 liver lesions (≤20...
<i>Background/Aims:</i> Pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, has been shown to inhibit growth and induce apoptosis in human hepatocellular carcinoma (HCC) cells. However, the potential benefit of pravastatin HCC patients still not characterized, which prompted us test efficacy with advanced HCC. <i>Methods:</i> We investigated prospectively cohort 183 who had selected for palliative treatment by transarterial chemoembolization...
PURPOSE Image analysis is one of the most promising applications artificial intelligence (AI) in health care, potentially improving prediction, diagnosis, and treatment diseases. Although scientific advances this area critically depend on accessibility large-volume high-quality data, sharing data between institutions faces various ethical legal constraints as well organizational technical obstacles. METHODS The Joint Imaging Platform (JIP) German Cancer Consortium (DKTK) addresses these...
Abstract Background Patients with cirrhosis and ascites (and portal hypertension) are at risk of developing acute kidney injury (AKI). Although many etiologies exist, hepatorenal AKI (HRS-AKI) remains a frequent difficult-to-treat cause, very high mortality when left untreated. The standard care is the use terlipressin albumin. This can lead to reversal AKI, which associated survival. Nevertheless, only approximately half patients achieve this even after for new episodes HRS-AKI. TIPS...
Abstract To examine the comparative robustness of computed tomography (CT)-based conventional radiomics and deep-learning convolutional neural networks (CNN) to predict overall survival (OS) in HCC patients. Retrospectively, 114 patients with pretherapeutic CT liver were randomized into a development (n = 85) validation 29) cohort, including all tumor stages several applied therapies. In addition clinical parameters, image annotations parenchyma findings on available. Cox-regression based...
To investigate image quality and vascular delineation of multi-detector row computed tomographic (CT) angiography at various kilovoltage settings.Thirty patients were investigated with a standardized CT protocol, three groups 10 consecutive examined 80, 120, 140 kV, respectively. Three blinded readers independently evaluated images graded parameters, diagnostic confidence, intracranial arteries veins. Vascular attenuation values, dose indices, length products assessed quantitatively. For...
Abstract Radioembolization therapy (RE) is an efficient locoregional treatment for liver metastases from colorectal cancer. Serum biomarkers involved in immunogenic cell death are potentially valuable early predicting response and estimating prognosis. In a prospective observation study, blood samples were taken 49 consecutive cancer patients with extensive hepatic before, 24 48 hr after RE. levels of high mobility group box 1 (HMGB1), receptor glycation end products (RAGE) activity...
In acute pancreatitis, endoplasmic reticulum (ER) stress prompts an accumulation of malfolded proteins inside the ER, initiating unfolded protein response (UPR). Because ER chaperone tauroursodeoxycholic acid (TUDCA) is known to inhibit UPR in vitro, this study examined vivo effects TUDCA experimental pancreatitis model. Acute was induced Wistar rats using caerulein, with or without prior treatment. components were analyzed, including binding (BiP), phosphorylated kinase-like kinase (pPERK),...
The aim of this study was to assess the impact advanced technology new ExAblate 2100 system (Insightec Ltd, Haifa, Israel) for magnetic resonance imaging (MRI)-guided focused ultrasound surgery on treatment outcomes in patients with symptomatic uterine fibroids, as measured by nonperfused volume ratio.This is a retrospective analysis 115 women (mean age, 42 years; range, 27-54 years) fibroids who consecutively underwent MRI-guided single center generation from November 2010 June 2011. Mean ±...
Selective Internal Radiation Therapy (SIRT) is a new and effective locoregional anticancer therapy for colorectal cancer patients with liver metastases. Markers prediction of response prognosis are needed the individual management those undergoing SIRT.Blood samples were prospectively consecutively taken from 49 extensive hepatic metastases before, three, six, 24 48 h after SIRT to analyze concentrations nucleosomes further laboratory parameters, compare them regularly determined 3 months...
Background. Stereotactic radiation therapy is an evolving modality to treat otherwise unresectable liver metastases. In this analysis, two local therapies: 1) single session robotic radiosurgery (RRS) and 2) percutaneous radiofrequency ablation (RFA) were compared in a total of 60 heavily pretreated colorectal cancer patients. Methods. Thirty patients with 35 metastases not qualifying for surgery that treated curative intent RRS prospectively followed. To compare efficacy both treatment...
Clinically relevant postoperative pancreatic fistula (CR-POPF) is a common severe surgical complication after surgery. Current risk stratification systems mostly rely on intraoperatively assessed factors like manually determined gland texture or blood loss. We developed preoperatively available image-based score predicting CR-POPF as of head resection. Frequency and occurrence salvage completion pancreatectomy during the hospital stay were associated with an intraoperative (sFRS)...
Endoplasmic reticulum (ER) stress leads to accumulation of un- or misfolded proteins inside the ER and initiates unfolded protein response (UPR). Several UPR components are physiologically involved in pancreatic development pathophysiologically activated during acute pancreatitis. However, exact role exocrine acini is mainly unclear. The present study examined effects tauroursodeoxycholic acid (TUDCA), a known chaperone, on acinar function components. Isolated rat were stimulated by...
No AccessJournal of UrologyAdult Urology1 Nov 2010Tumor Infiltrated Hilar and Mediastinal Lymph Nodes are an Independent Prognostic Factor for Decreased Survival After Pulmonary Metastasectomy in Patients With Renal Cell Carcinoma Hauke Winter, Georgios Meimarakis, Martin K. Angele, Manuela Hummel, Michael Staehler, Ralf-Thorsten Hoffmann, Rudolf A. Hatz, Florian Löhe WinterHauke Winter Department General Thoracic Surgery, University Munich, Grosshadern Campus, Germany , MeimarakisGeorgios...
Inhalt Seite Wesentliche Neuerungen e84 1 Informationen zu dieser Leitlinie e85 1.1 Herausgeber 1.2 Federführende Fachgesellschaft(en) 1.3 Finanzierung der 1.4 Kontakt 1.5 Zitierweise 1.6 Besonderer Hinweis 1.7 Ziele des Leitlinienprogramms Onkologie 1.8 Weitere Dokumente e86 1.9 Zusammensetzung Leitliniengruppe 1.9.1 Koordination 1.9.2 Beteiligte Fachgesellschaften und Organisationen 1.9.3 Arbeitsgruppen e88 1.9.4 Patientenbeteiligung 1.9.5 Methodische Begleitung 1.10 Abkürzungsverzeichnis...