A5005577019- Eating Disorders and Behaviors
- Tryptophan and brain disorders
- Alcohol Consumption and Health Effects
- Stress Responses and Cortisol
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Obsessive-Compulsive Spectrum Disorders
- Regulation of Appetite and Obesity
- Metabolomics and Mass Spectrometry Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Adipose Tissue and Metabolism
- Eicosanoids and Hypertension Pharmacology
- Renal cell carcinoma treatment
- Lipoproteins and Cardiovascular Health
- Immune Response and Inflammation
- Ion Transport and Channel Regulation
- Autoimmune Neurological Disorders and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- S100 Proteins and Annexins
- Folate and B Vitamins Research
- Blood transfusion and management
- Traumatic Brain Injury and Neurovascular Disturbances
Otto-von-Guericke University Magdeburg
2015-2025
University Hospital Magdeburg
2007-2023
Klinikum Magdeburg
2011
University Hospital Leipzig
2006-2008
University of Basel
2005
In observational studies, hyperhomocysteinemia has been found to be a risk factor for total mortality and cardiovascular events in patients with end-stage renal disease. These have grossly elevated homocysteine levels that can lowered by supplementation folic acid vitamin B(12). We conducted randomized clinical trial B vitamins reduce therefore mortality.This randomized, double-blind multicenter study was 33 dialysis centers north east Germany between July 2002 2008. randomly assigned 650...
Abstract Innate immunity has been linked to initiation of Alzheimer’s disease and multiple sclerosis. Moreover, risk first-episode psychosis (FEP) schizophrenia (Sz) is increased after various infections in predisposed individuals. Thus, we hypothesized an analogous role innate with C-reactive protein (CRP) non-affective psychosis. Differential blood count, CRP, neutrophil monocyte–macrophage activation markers, cortisol psychotic symptoms (Positive Negative Syndrome Scale [PANSS]) were...
We recently reported increased levels of neutrophils, monocytes and C-reactive protein (CRP) correlated with symptom severity in acute schizophrenia. Here, we investigated if a similar pattern innate immune system activation occurs major depression (MD).We assessed differential blood counts, CRP, symptoms (HAMD-21) psychosocial functioning (GAF) controls (n = 129) patients first (FEMD: n 82) or recurrent (RMD: 47) disease episodes MD at baseline (T0; hospital admission) after 6-weeks...
Background: At present, recent ethanol consumption can be routinely detected with certainty only by direct measurement of concentration in blood or urine. Because is rapidly eliminated from the circulation, however, time span for this detection range hours. Several new markers have been proposed to extend interval, but their characteristics not yet justified use routine clinical practice. We therefore investigated three and compared kinetics sensitivities: (1) fatty acid ethyl esters (FAEEs)...
Polymorphonuclear neutrophils (PMN) mediate early immunity to infection but can also cause host damage if their effector functions are not controlled. Their lack or dysfunction is associated with severe health problems and thus the analysis of PMN physiology a central issue. One prerequisite for availability purified cells from primary organs. While human easily isolated peripheral blood, this approach less suitable mice due limited blood. Instead, bone marrow (BM) an available reservoir...
Circulating proteins are widely used as biomarkers in clinical applications for the diagnosis, prediction, and treatment of numerous diseases. Immunoassays most common technologies quantification protein exist various formats. Traditional immunoassays offer sensitive fast analyses but cannot differentiate between proteoforms. Protein microheterogeneity, mainly due to post-translational modification, has been recognized a fingerprint different pathologies, knowledge about proteoforms is an...
Anorexia nervosa (AN) is an often chronic and debilitating psychiatric disease whose etiology not completely understood. Recently, a potential role of inflammation has emerged in other diseases, such as depression, PTSD schizophrenia. The first results adults with AN seemed to confirm low-grade proinflammatory state until recent studies presented more differential findings. Studying adolescents shorter illness duration fewer confounding factors might help elucidate the underlying...
Anorexia nervosa (AN) is a severe eating disorder that predominantly affects females and typically manifests during adolescence. There increasing evidence serum cytokine levels are altered in individuals with AN. Previous research has largely focused on adult patients, assuming low-grade pro-inflammatory state. The of the tumour necrosis factor-alpha (TNF-α), interleukin (IL)-1β, IL-6 IL-15, which pro-inflammatory, were examined 63 female adolescents AN 41 age-matched healthy controls (HC)....
The neurotrophic growth factor brain-derived (BDNF) plays a crucial role in various neurodegenerative and psychiatric diseases, such as Alzheimer's disease, schizophrenia depression. BDNF has been proposed potential biomarker for diagnosis, prognosis monitoring therapy. Understanding the factors influencing levels whether they follow circadian rhythm is essential interpreting fluctuations measurements. We aimed to investigate of by collecting multiple peripheral venous blood samples from...
The COVID-19 pandemics has caused the death of almost six million people worldwide. In order to establish collective immunity, first vaccines that were approved in Germany vector virus-based vaccine Vaxzevria and mRNA Comirnaty Spikevax, respectively. As it was reported SARS-CoV-2 can trigger autoimmunity, is significant interest investigate whether evoke formation autoantibodies subsequent autoimmunity. Here, we analyzed immune responses after different vaccination regimens (mRNA/mRNA,...
Inhalt Seite Wesentliche Neuerungen e84 1 Informationen zu dieser Leitlinie e85 1.1 Herausgeber 1.2 Federführende Fachgesellschaft(en) 1.3 Finanzierung der 1.4 Kontakt 1.5 Zitierweise 1.6 Besonderer Hinweis 1.7 Ziele des Leitlinienprogramms Onkologie 1.8 Weitere Dokumente e86 1.9 Zusammensetzung Leitliniengruppe 1.9.1 Koordination 1.9.2 Beteiligte Fachgesellschaften und Organisationen 1.9.3 Arbeitsgruppen e88 1.9.4 Patientenbeteiligung 1.9.5 Methodische Begleitung 1.10 Abkürzungsverzeichnis...
Die Langversion der S3-Leitlinie "Diagnostik und Therapie des Hepatozellulären Karzinoms biliären Karzinome" umfasst zwei Tumorentitäten. letzte Version Leitlinie wurde im August 2023 veröffentlicht.
Die Langversion der S3-Leitlinie "Diagnostik und Therapie des Hepatozellulären Karzinoms biliären Karzinome" umfasst zwei Tumorentitäten. letzte Version Leitlinie wurde im August 2023 veröffentlicht.
Die S3-Leitlinie "Diagnostik und Therapie des Hepatozellulären Karzinoms der biliären Karzinome" umfasst zwei Tumorentitäten. letzte Version Leitlinie wurde im August 2023 veröffentlicht.
Both medical and forensic needs require reliable detection of earlier ethanol intake after the disappearance from blood. The esters with free fatty acids (FAEEs) are candidate markers this kind. However, it is unknown whether FAEEs can serve as a marker for single prior intake. In addition, period which elevated unknown. Therefore, we measured in heavy drinkers admitted to detoxification, healthy subjects drinking experiment.Blood 30 was obtained up 5 days during detoxification psychiatric...
DCs contribute to immune homeostasis under physiological conditions and regulate the activation during infection. The deubiquitinase A20 inhibits of NF-κB-dependent reactions, prevents hyperactivation steady-state conditions. However, role DC-specific pathological is unknown. Here, we demonstrate that upon injection low-dose LPS, mice with deletion (CD11c-Cre A20(fl/fl) ) died within 6 h, whereas controls survived. LPS-induced mortality in CD11c-Cre was characterized by increased serum...
Abstract Bile acids (BAs) are increasingly recognised as metabolic regulators, potentially improving insulin sensitivity following bariatric surgery. However, physiological relevance of such observations remains unknown. Hence, we analysed serum BA composition and associated gut-derived hormone levels lifestyle-induced weight loss in individuals with syndrome (MetS). 74 non-smoking men (45–55 yr) MetS were randomised to a program (supervision via telemonitoring) or control arm. Before after...