A5059529807- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Mental Health Research Topics
- Metabolomics and Mass Spectrometry Studies
- Stress Responses and Cortisol
- Advanced Proteomics Techniques and Applications
- Digital Mental Health Interventions
- Mental Health Treatment and Access
- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Bioinformatics and Genomic Networks
- Genetic Associations and Epidemiology
- Treatment of Major Depression
- Diet and metabolism studies
- Diabetes and associated disorders
- Receptor Mechanisms and Signaling
- Gut microbiota and health
- Gene expression and cancer classification
- Neurotransmitter Receptor Influence on Behavior
- Maternal Mental Health During Pregnancy and Postpartum
- Mass Spectrometry Techniques and Applications
- Health, Environment, Cognitive Aging
- Autism Spectrum Disorder Research
University of Cambridge
2016-2025
Erasmus MC
2010-2018
Erasmus University Rotterdam
2005-2016
Florey Institute of Neuroscience and Mental Health
2015
University of Bari Aldo Moro
2015
Roche (Switzerland)
2015
Max Planck Institute of Psychiatry
2015
Ludwig-Maximilians-Universität München
2015
King's College London
2015
The University of Melbourne
2015
Significance Depression and anxiety have been linked to increased inflammation. However, we do not know if inflammatory status predates onset of disease or whether it contributes depression symptomatology. We report preexisting individual differences in the peripheral immune system that predict promote stress susceptibility. Replacing a stress-naive animal’s with stressed animal increases susceptibility social including repeated defeat (RSDS) witness (a purely emotional form stress)....
In development, timing is of the utmost importance, and developmental processes often changes as organisms evolve. human evolution, retardation, or neoteny, has been proposed a possible mechanism that contributed to rise many human-specific features, including an increase in brain size emergence cognitive traits. We analyzed mRNA expression prefrontal cortex humans, chimpanzees, rhesus macaques determine whether neotenic are present at gene level. show transcriptome dramatically remodeled...
Kainate-preferring receptors are a subclass of ionotropic glutamate that might play role in brain development. The expression the five known genes encoding kainate receptor subunits (GluR-5, -6, -7, KA-1, and KA-2) was studied by situ hybridization during pre- postnatal development rat brain. We compared combined patterns these with autoradiography using 3H-kainate developing from embryonic day 12 (E12) through to adult. Although mRNAs for (except KA-1) can be detected at stage E12,...
Cerebellar granule cells express six GABA A receptor subunits abundantly (α 1 , α 6 β 2 3 γ and δ) assemble various pentameric subtypes with unknown subunit compositions; however, the rules guiding assembly are unclear. Here, removal of intact protein from cerebellar allowed perturbations in other levels to be studied. Exon 8 mouse gene was disrupted by homologous recombination. In −/− cells, δ selectively degraded as seen immunoprecipitation, immunocytochemistry, immunoblot analysis...
Background Psychosis is a severe mental condition that characterized by loss of contact with reality and typically associated hallucinations delusional beliefs. There are numerous psychiatric conditions present psychotic symptoms, most importantly schizophrenia, bipolar affective disorder, some forms depression referred to as depression. The pathological mechanisms resulting in symptoms not understood, nor it understood whether the various illnesses result similar biochemical disturbances....
Abstract Recent studies have suggested that immune function may be dysregulated in persons with depressive and anxiety disorders. Few examined the expression of cytokines response to ex vivo stimulation blood by lipopolysaccharide (LPS) study innate production capacity depression anxiety. To investigate this, baseline data from Netherlands Study Depression Anxiety (NESDA) were used, including (18–65 years; 66% women) current (that is, past month; N =591) or remitted ( =354) DSM-IV disorders...
We describe the validation of a serum-based test developed by Rules-Based Medicine which can be used to help confirm diagnosis schizophrenia. In preliminary studies using multiplex immunoassay profiling technology, we identified disease signature comprised 51 analytes could distinguish schizophrenia (n = 250) from control 230) subjects. next stage, these were as refined 51-plex panel for large independent cohort 577) and 229) The resulting yielded an overall sensitivity 83% specificity with...
Abstract Recent research efforts have progressively shifted towards preventative psychiatry and prognostic identification of individuals before disease onset. We describe the development a serum biomarker test for at risk developing schizophrenia based on multiplex immunoassay profiling analysis 957 samples. First, we conducted meta-analysis five independent cohorts 127 first-onset drug-naive patients 204 controls. Using least absolute shrinkage selection operator regression, identified an...
Although peripheral immune system abnormalities have been linked to schizophrenia pathophysiology, standard antipsychotic drugs show limited immunological effects. Thus, more effective treatment approaches are required. Probiotics microorganisms that modulate the response of host and, therefore, may be beneficial patients. The aim this study was examine possible immunomodulatory effects probiotic supplementation in chronic concentrations 47 immune-related serum proteins were measured using...
Abstract Much has still to be learned about the molecular mechanisms of depression. This study aims gain insight into contributing by identifying serum proteins related major depressive disorder (MDD) in a large psychiatric cohort study. Our sample consisted 1589 participants Netherlands Study Depression and Anxiety, comprising 687 individuals with current MDD (cMDD), 482 remitted (rMDD) 420 controls. We studied relationship between status levels 171 detected on multi-analyte profiling...
Abstract Innate immunity has been linked to initiation of Alzheimer’s disease and multiple sclerosis. Moreover, risk first-episode psychosis (FEP) schizophrenia (Sz) is increased after various infections in predisposed individuals. Thus, we hypothesized an analogous role innate with C-reactive protein (CRP) non-affective psychosis. Differential blood count, CRP, neutrophil monocyte–macrophage activation markers, cortisol psychotic symptoms (Positive Negative Syndrome Scale [PANSS]) were...
Major depressive disorder (MDD) is a complex and multi-factorial disorder. Although genetic factors other molecular aspects of MDD have been widely studied, the underlying pathological mechanisms are still mostly unknown. We sought to investigate pathophysiology by identifying characterising serum differences their correlation symptom severity in first onset, antidepressant drug-naïve patients. performed an exploratory profiling study on samples patients controls using multiplex immunoassay...
Significance Deciphering molecular mechanisms at the glycome level in mammalian brain remains a missing piece of puzzle neuroscience due to intrinsic complexity glycosylation and lack analytical tools. Here, we uncovered variation diversity expression human mouse samples according spatial temporal differences. We further constructed comprehensive synthesis map using glycans structurally elucidated by LC-MS/MS found strong evidence on conservation developmental divergence prefrontal cortex...
We screened a custom-made candidate gene cDNA array comprising 300 genes. Genes chosen have either been implicated in schizophrenia, make conceptual sense the light of current understanding disease, or are located on high-susceptibility chromosome locations. The screen using prefrontal cortex tissue from 10 schizophrenia and control brains revealed robust up-regulation apolipoprotein L1 (apo L1) by 2.6-fold. finding was cross-validated blinded quantitative PCR study Stanley Foundation brain...
Introduction Abnormal phosphorylation of tau is a feature Alzheimer's disease (AD), which develops prematurely in Down syndrome (DS) patients. Cognitive impairment also recognized as clinical characteristic schizophrenia, does not appear to be associated with tau‐aggregate formation. Several kinases can phosphorylate cell‐free assays. Here we show increased activity mitogen‐activated protein (MAPKs) (including ERK1/2, SAPKs and p38) post mortem AD DS brains, could accounted for by expression...