A5101893089- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Immune cells in cancer
- Liver Diseases and Immunity
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- Liver physiology and pathology
- Neuroendocrine Tumor Research Advances
- Cancer Immunotherapy and Biomarkers
- Pancreatitis Pathology and Treatment
- Lung Cancer Research Studies
- Advanced Statistical Methods and Models
- Cancer Mechanisms and Therapy
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Frailty in Older Adults
- Bladder and Urothelial Cancer Treatments
- Hormonal and reproductive studies
- Prostate Cancer Diagnosis and Treatment
- Evaluation Methods in Various Fields
- Advanced Decision-Making Techniques
- Photoreceptor and optogenetics research
Tongji Hospital
2015-2025
Huazhong University of Science and Technology
2014-2025
Tianjin Medical University
2020-2024
Tianjin Medical University General Hospital
2021-2024
Sun Yat-sen University
2013-2024
The First Affiliated Hospital, Sun Yat-sen University
2019-2024
Tianjin Infectious Diseases Hospital
2024
Zhengzhou University
2019-2021
Henan Academy of Sciences
2021
Chinese University of Hong Kong
2017-2019
Objective Myeloid-derived suppressor cells (MDSCs) contribute to tumour immunosuppressive microenvironment and immune-checkpoint blockade resistance. Emerging evidence highlights the pivotal functions of cyclin-dependent kinases (CDKs) in immunity. Here we elucidated role tumour-intrinsic CDK20, or cell cycle-related kinase (CCRK) on immunosuppression hepatocellular carcinoma (HCC). Design Immunosuppression MDSCs derived from patients with HCC relationship CCRK were determined by flow...
Human hepatocellular carcinoma (HCC) is driven and maintained by liver cancer stem cells (LCSCs) that display cell properties. These LCSCs are promoted the intersecting of Notch Wnt/β-Catenin signaling pathways. In this study, we demonstrate with markers CD90, CD24, CD13, CD133 possess properties self-renewal tumorigenicity in NOD/SCID mice. The increased expression these was correlated advanced disease stage, larger tumors, worse overall survival 61 HCC cases. We also found both...
CD90 has been identified as a marker for liver cancer stem cells (CSCs) that are responsible tumorigenic activity, but it is not known how CD90+ contribute to tumor initiation and progression. Our data demonstrated high expression of in Hepatocellular Carcinoma (HCC) tissues correlated with venous filtration HCC patients. isolated from cell lines exhibited increased tumorigenicity, chemoresistance, invasion metastasis. Notch pathway was activated we found inhibition CSCs decreased invasion,...
Abstract Background Liver cancer stem cells (LCSCs) contribute to hepatocellular carcinoma (HCC) development, metastasis, and drug resistance. MSI2 Notch1 signaling are involved in the maintenance of CSCs. However, it is unknown whether CD44v6+ LCSCs. Therefore, we investigated clinical significance function its relationship with stemness properties Methods The expression CD44v6 were detected by fresh specimens a HCC tissue microarray. microarray containing 82 samples was used analyze...
Extrusion free-forming, as a rapid prototyping technique, is extensively applied in fabricating ceramic material bone tissue engineering. To improve the osteoinductivity of nano-hydroxyapatite (nHA) scaffold fabricated by extrusion this study, we incorporated new peptide (P28) and optimized superficial microstructure after shaping controlling sintering temperature. P28, novel morphogenic protein 2 (BMP-2)-related peptide, was designed study. Analysis structure, physicochemical properties...
Older individuals usually have greater arterial stiffness, lower serum Klotho levels and a incidence of chronic kidney disease (CKD). The current study aimed to evaluate the interaction effect estimated pulse wave velocity (ePWV) on CKD in Americans. Data from National Health Nutrition Examination Survey database 2007 2016 were used. Participants with data for assessment ePWV enrolled. associations between analyzed via restricted cubic spline analysis linear regression model. exposure...
Background: Vitamin D insufficiency and deficiency are common in patients with cardiovascular disease (CVD). We aimed to prospectively examine the associations of serum 25-hydroxyvitamin [25(OH)D] concentrations all-cause cause-specific mortality among adult existing CVD. Methods: included 37,079 CVD from UK Biobank study, a prospective cohort half million participants aged 40–69 years. defined as those who suffered coronary heart disease, atrial fibrillation, failure, or stroke. The 25(OH)D...
Hepatitis B virus X protein (HBx) is implicated in the pathogenesis of hepatocellular carcinoma (HCC) via a network signaling pathways. Notch pathway major member network. may generate opposing effect different steps carcinogenesis, depending on tumor cell type and status other pathways, such as Wnt pathway. Our previous studies have shown that activated Notch1 required for HBx to promote proliferation survival human hepatic line L02. However, exact mechanisms remain vague. Here, we used...
Recent studies demonstrated the importance of fibrosis in promoting an immunosuppressive liver microenvironment and thereby aggressive hepatocellular carcinoma (HCC) growth resistance to immune checkpoint blockade (ICB), particularly via monocyte-to-monocytic myeloid-derived suppressor cell (M-MDSC) differentiation triggered by hepatic stellate cells (HSCs). We thus aimed identify druggable targets these myeloid for HCC therapy.
Dysregulation of transcription factors contributes to the carcinogenesis and progression cancers. However, their roles in clear cell renal carcinoma remain largely unknown. This study aimed evaluate clinical significance TFs investigate potential molecular mechanisms ccRCC. Data were accessed from cancer genome atlas kidney cohort. Bioinformatics algorithm was used copy number alterations mutations, differentially expressed TFs’ analysis. Univariate multivariate Cox regression analyses...
Substantial studies indicate that autoantibodies to tumor-associated antigens (TAAbs) arise in early stage of lung cancer (LC). However, since single TAAbs as non-invasive biomarkers reveal low diagnostic performances, a panel approach is needed provide more clues for detection LC. In the present research, potential were screened 150 serum samples by focused protein array based on 154 proteins encoded driver genes. Indirect enzyme-linked immunosorbent assay (ELISA) was used verify and...
Background and objectives: Atypical thymic carcinoids (ATCs) are rare mediastinal malignancies that lack established treatment guidelines. Capecitabine temozolomide (CapTem) has demonstrated significant efficacy in pancreatic neuroendocrine neoplasms (NENs), while its applicability effectiveness ATCs remain underexplored. This study seeks to investigate the efficacy, safety, prognostic factors associated with CapTem ATC patients. Design methods: Thirty-eight patients treated at our center...
The lack of a useful biomarker partly contributes to the increased mortality non-small cell lung cancer (NSCLC). MiRNAs have become increasingly appreciated in diagnosis NSCLC. In present study, we used microarray screen 2,549 miRNAs serum samples from training cohort (NSCLC, n = 10; healthy, 10) discover differentially expressed (DEMs). Quantitative reverse-transcription polymerase chain reaction (qRT-PCR) assay was applied validate expression level selected overexpressed DEMs NSCLC...