A5100744686- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Histone Deacetylase Inhibitors Research
- Immune Cell Function and Interaction
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Epigenetics and DNA Methylation
- Single-cell and spatial transcriptomics
- Cancer Mechanisms and Therapy
- Genetic factors in colorectal cancer
- Cancer, Lipids, and Metabolism
- Crystallography and molecular interactions
- Liver Disease Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Molecular Biology Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Retinoids in leukemia and cellular processes
- Gut microbiota and health
- Chemokine receptors and signaling
- Bioactive natural compounds
- Bioinformatics and Genomic Networks
- Cancer-related gene regulation
- PI3K/AKT/mTOR signaling in cancer
- Gene expression and cancer classification
- Traditional Chinese Medicine Analysis
Chinese University of Hong Kong
2017-2024
Botswana Geoscience Institute
2024
BGI Research
2024
BGI Group (China)
2024
Shanxi Medical University
2024
Second Xiangya Hospital of Central South University
2018-2023
Central South University
2018-2023
Ningxia Medical University General Hospital
2019-2021
Ningxia Medical University
2019-2021
University of Hong Kong
2019-2021
HDAC8 inhibition elicits durable responses to immune checkpoint blockade by improving adaptive through enhancer reprogramming.
Objective Therapy-induced tumour microenvironment (TME) remodelling poses a major hurdle for cancer cure. As the majority of patients with hepatocellular carcinoma (HCC) exhibits primary or acquired resistance to antiprogrammed cell death (ligand)-1 (anti-PD-[L]1) therapies, we aimed investigate mechanisms underlying adaptation immune-checkpoint targeting. Design Two immunotherapy-resistant HCC models were generated by serial orthotopic implantation cells through anti-PD-L1-treated...
Objective Myeloid-derived suppressor cells (MDSCs) contribute to tumour immunosuppressive microenvironment and immune-checkpoint blockade resistance. Emerging evidence highlights the pivotal functions of cyclin-dependent kinases (CDKs) in immunity. Here we elucidated role tumour-intrinsic CDK20, or cell cycle-related kinase (CCRK) on immunosuppression hepatocellular carcinoma (HCC). Design Immunosuppression MDSCs derived from patients with HCC relationship CCRK were determined by flow...
Hepatocellular carcinoma (HCC), mostly developed in fibrotic/cirrhotic liver, exhibits relatively low responsiveness to immune checkpoint blockade (ICB) therapy. As myeloid-derived suppressor cell (MDSC) is pivotal for immunosuppression, we investigated its role and regulation the fibrotic microenvironment with an aim of developing mechanism-based combination immunotherapy.Functional significance MDSCs was evaluated by flow cytometry using two orthotopic HCC models liver setting via carbon...
Obesity increases the risk of hepatocellular carcinoma (HCC) especially in men, but molecular mechanism remains obscure. Here, we show that an androgen receptor (AR)-driven oncogene, cell cycle-related kinase (CCRK), collaborates with obesity-induced pro-inflammatory signaling to promote non-alcoholic steatohepatitis (NASH)-related hepatocarcinogenesis. Lentivirus-mediated Ccrk ablation liver male mice fed high-fat high-carbohydrate diet abrogates not only obesity-associated lipid...
Genomic screening uncovered interferon-gamma (IFNγ) pathway defects in tumours refractory to immune checkpoint blockade (ICB). However, its non-mutational regulation and reversibility for therapeutic development remain less understood.
Radix Salviae Miltiorrhizae (RSM), a well-known traditional Chinese medicine, has been shown to inhibit tumorigenesis in various human cancers. However, the anticancer effects of RSM on hepatocellular carcinoma (HCC) and underlying mechanisms action remain be fully elucidated. In this study, we aimed elucidate molecular treatment HCC using network pharmacology approach. vivo vitro experiments were also performed validate therapeutic HCC. total, 62 active compounds from 72 HCC-related targets...
The preexistence of immune cells in the tumor microenvironment substantiates efficacy immunotherapy cancer patients. Although complex intratumoral heterogeneity has been extensively studied single cell resolution, hi-res spatial investigations are limited. In this study, we performed a transcriptome analysis 4 colorectal adenocarcinoma specimens and 2 paired distant normal to identify molecular pattern involved discontinuous inflammatory response pathologically annotated regions. Based on...
Colorectal cancer (CRC) patients with mismatch repair (MMR)-deficient (dMMR) but not MMR-proficient (pMMR) tend to benefit from immune checkpoint blockade (ICB) therapy. To profile the tumor microenvironments (TME) underlying these varied therapeutic responses, we integrate spatial enhanced resolution omics-sequencing (Stereo-seq), single-cell RNA sequencing, and multiplexed imaging analysis create high-definition maps of tumors treatment-naïve ICB-treated CRC patients. Our results identify...
Numerous studies have shown that resveratrol can induce apoptosis in cancer cells. Trans‐3, 5, 4 ′ ‐trimethoxystilbene (TMS), a novel derivative of resveratrol, is more potent anticancer compound than and Herein, we examined the mechanisms involved TMS‐mediated sensitization human osteosarcoma (143B) cells to TNF‐related apoptosis‐inducing ligand‐ (TRAIL‐) induced apoptosis. Our results showed cotreatment with TSM TRAIL activated caspases increased PARP‐1 cleavage 143B Decreasing cellular...
Abstract The tumor microenvironment plays an instrumental role in cancer development and treatment response/resistance. Accumulating evidence is underscoring the fundamental importance of epigenetic regulation immune evasion. Epigenetic modification agents represent a ‘double-edged sword’, as they can exert divergent effects on cells milieu stromal cells. Our integrative epigenomics analysis has elucidated previously unexplored functions histone deacetylase 8 (HDAC8) promoting...
Abstract Multimodal omics provide deeper insight into the biological processes and cellular functions, especially transcriptomics proteomics. Computational methods have been proposed for integration of single-cell multimodal However, existing primarily concentrate on alignment different omics, overlooking unique information inherent in each type. Moreover, as majority cohorts only encompass one it becomes critical to transfer knowledge learnt from enhance unimodal analysis. Therefore, we a...
<title>Abstract</title> Colorectal cancer (CRC) patients with mismatch repair (MMR)-deficient (dMMR) but not MMR-proficient (pMMR) tend to benefit from immune checkpoint blockade (ICB) therapy. To uncover the rules governing these varied therapeutic responses, we integrated spatial enhanced resolution omics-sequencing (Stereo-seq), single-cell RNA sequencing, and multiplexed imaging analysis create high-definition maps of tumors treatment-naïve ICB-treated CRC patients. Our results...
<h3>Background</h3> Hepatocellular carcinoma (HCC), mostly developed in fibrotic/cirrhotic liver, exhibits relatively low responsiveness to immune-checkpoint blockade (ICB) therapy. As myeloid-derived suppressor cell (MDSC) is pivotal for immunosuppression, we investigated its role and regulation the fibrotic microenvironment with an aim of developing mechanism-based combination immunotherapy. <h3>Methods</h3> Functional significance MDSCs was evaluated by flow cytometry using two orthotopic...
<h3>Background</h3> The heterogeneity and diverse pathogenic conditions of HCC construct an immunosuppressive tumor microenvironment (TME) which may lead to low immune checkpoint blockade (ICB) therapeutic responsiveness. Therefore, alleviating immunosuppression potentiate ICB anti-cancer immunity is in urgent need. Myeloid-derived suppressor cells (MDSCs) with potent T cell suppressive property are correlated poor prognosis unsatisfactory response HCC. In this study, we aimed study the...