A5057683901- Reproductive System and Pregnancy
- Reproductive Physiology in Livestock
- IL-33, ST2, and ILC Pathways
- Cancer-related molecular mechanisms research
- Natural Compounds in Disease Treatment
- Histone Deacetylase Inhibitors Research
- Immune Cell Function and Interaction
- Congenital gastrointestinal and neural anomalies
- Mycobacterium research and diagnosis
- Epigenetics and DNA Methylation
- Nephrotoxicity and Medicinal Plants
- Andrographolide Research and Applications
- Extracellular vesicles in disease
- Immune cells in cancer
- Endometriosis Research and Treatment
- RNA regulation and disease
- Microbial Metabolism and Applications
- melanin and skin pigmentation
- Adenosine and Purinergic Signaling
- Milk Quality and Mastitis in Dairy Cows
- Ginger and Zingiberaceae research
Huazhong Agricultural University
2021-2024
Chinese University of Hong Kong
2024
Mastitis, caused by a variety of pathogenic microorganisms, seriously threatens the safety and economic benefits dairy industry. Vitexin, flavone glucoside found in many plant species, has been widely reported to have antioxidant, anti-inflammatory, antiviral, anticancer, neuroprotective, cardioprotective effects. However, few studies explored effect vitexin on mastitis. This study is aimed at exploring whether antioxidant anti-inflammatory functions can improve Staphylococcus aureus-induced...
Genomic screening uncovered interferon-gamma (IFNγ) pathway defects in tumours refractory to immune checkpoint blockade (ICB). However, its non-mutational regulation and reversibility for therapeutic development remain less understood.
Although the specific expression of long noncoding RNA (lncRNA) in mastitis tissue has been reported, few studies have involved differential lncRNA exosomes (Exo) and its mechanism function. We screened an associated with FAS translational regulation (lnc-AFTR) through exosomal sequencing, clarified function molecular mechanism. Lnc-AFTR is markedly downregulated Staphylococcus aureus-Exo S. aureus-induced MAC-T cell as well tissue. Overexpression lnc-AFTR (oe-AFTR-Exo) significantly...
Persistent endometritis caused by bacterial infections has lethal effects on the reproductive performance of dairy cattle, which compromises animal welfare and delays or prevents pregnancy. The microRNA (miRNA) miR-34 family plays a pivotal role in inflammatory process; however, precise mechanism miR-34a not been thoroughly elucidated to date.In this study, endometrium cows diagnosed with was harvested for culture Gram staining evaluate contamination uterus. Based this, bovine endometrial...
Background: Sodium new houttuyfonate (SNH) has been reported to have anti-inflammatory, anti-fungal, and anti-cancer effects. However, few studies investigated the effect of SNH on breast cancer. The aim this study was investigate whether therapeutic potential for targeting Methods: Immunohistochemistry Western blot analysis were used examine expression proteins, flow cytometry detect cell apoptosis ROS levels, transmission electron microscopy observe mitochondria. Results: Differentially...
Solving the reproductive barriers of dairy cows has become one most critical factors determining industry’s development. Clinically, inflammation disease like endometritis is leading causes in reducing production’s financial viability. MiR-193 family can induce cells apoptosis and differentiation been reported various diseases. LGR4 plays a vital role system development immune regulation, it closely related to animal function cytokine regulation. In this study, we observed negative...
Abstract Background Persistent endometritis lead by bacterial infections has lethal effects on the reproductive performance of dairy cattle, which not only compromise animal welfare but also delay or prevent pregnancy. MicroRNA (miRNA) miR-34 family plays a pivotal role in inflammatory process; however, precise mechanism miR-34a is still thoroughly revealed. Methods In this study, we established bovine endometrial epithelial cell (BENDs) inflammation model and mouse stimulation with...