A5073195392- Reproductive System and Pregnancy
- Reproductive Physiology in Livestock
- Cancer-related molecular mechanisms research
- Mycotoxins in Agriculture and Food
- Immune Response and Inflammation
- NF-κB Signaling Pathways
- Animal Nutrition and Physiology
- Gut microbiota and health
- Genetic and phenotypic traits in livestock
- Endometriosis Research and Treatment
- Milk Quality and Mastitis in Dairy Cows
- Peroxisome Proliferator-Activated Receptors
- Ginseng Biological Effects and Applications
- Effects of Environmental Stressors on Livestock
- MicroRNA in disease regulation
- Microbial infections and disease research
- Coccidia and coccidiosis research
- Genomics, phytochemicals, and oxidative stress
- Animal Genetics and Reproduction
- Cytokine Signaling Pathways and Interactions
- Bone Metabolism and Diseases
- Helminth infection and control
- Ruminant Nutrition and Digestive Physiology
- IL-33, ST2, and ILC Pathways
- Ferroptosis and cancer prognosis
Huazhong Agricultural University
2018-2025
South China Agricultural University
2023-2025
University of Agriculture Faisalabad
2020-2023
Cairo University
2023
The internalization of S. aureus in bMECs is a major pathogenic mechanism leading to mastitis, causing significant economic losses the dairy industry. Numerous plants contain Lut, natural flavonoid with anti-inflammatory and antioxidant properties. However, little known about Lut’s ability reduce inflammation caused by bMECs. This research aimed evaluate which Lut reduces aureus-induced Through GO KEGG enrichment analysis, researchers analyzed differentially expressed genes infected NCBI GEO...
It is well established that cancer cells depend upon aerobic glycolysis to provide the energy they need survive and proliferate. However, anti-glycolytic agents have yielded few positive results in human patients, part due dose-limiting side effects. Here, we discovered unexpected anti-cancer efficacy of Polydatin (PD) combined with 2-deoxy-D-glucose (2-DG), which a compound inhibits glycolysis. We demonstrated two breast cell lines (MCF-7 4T1) combination treatment PD 2-DG induced apoptosis...
Aflatoxin B1 (AFB1), a threatening mycotoxin, usually provokes oxidative stress and causes hepatotoxicity in animals humans. Luteolin (LUTN), well-known as an active phytochemical agent, acts strong antioxidant. This research was designed to investigate whether LUTN exerts protective effects against AFB1-induced explore the possible molecular mechanism mice. A total of forty-eight mice were randomly allocated following four treatment groups (n = 12): Group 1, physiological saline (CON). 2,...
Abstract Tibial dyschondroplasia (TD) with multiple incentives is a metabolic skeletal disease that occurs in fast-growing broilers. Perturbations the gut microbiota (GM) have been shown to affect bone homoeostasis, but mechanisms by which GM modulates metabolism TD broilers remain unknown. Here, using broiler model of TD, we noted elevated blood glucose (GLU) levels broilers, accompanied alterations pancreatic structure and secretory function damaged intestinal barrier function....
Aflatoxin B1 (AFB1) is a common mycotoxin that widely occurs in feed and has severe hepatotoxic effects both humans animals. Total flavonoids of Rhizoma Drynaria (TFRD), traditional Chinese medicinal herb, have multiple biological activities potential hepatoprotective activity. This study investigated the protective mechanisms TFRD against AFB1-induced liver injury. The results revealed supplementation with markedly lessened broiler intestinal permeability by increasing expression tight...
Acute lung injury (ALI) is a progressive clinical disease with high mortality rate, and characterized by an excessive uncontrolled inflammatory response. MicroRNAs (miRNAs) play critical role in various human diseases, have been recognized as important regulators of inflammation. However, the regulatory mechanisms mediated miRNAs involved Lipopolysaccharide (LPS)-induced inflammation ALI remain hazy. In this study, we found that miR-181a expression tissues mice LPS-stimulated RAW 264.7...
Abnormal inflammatory bias in the maternal-fetal interface leads to reproductive failure mammals. Placental exosomes are involved communication during pregnancy. However, whether placenta or fetus is regulating balance of uterine local inflammation through remains unclear, and mechanism must be further explored. Here we demonstrated that placenta-specific abundant peripheral blood dairy cows early pregnancy selectively load miRNAs, such as bta-miR-499. In vitro, placental exosome-derived...
Aflatoxin B₁ (AFB₁) is a widely spread mycotoxin contaminates food and feed, causing severe oxidative stress damages immunotoxicity. Grape seed proanthocyanidin (GSPE), natural antioxidant with wide range of pharmacological medicinal properties. The goal the present study was to investigate protective effects GSPE against AFB₁-induced immunotoxicity via NF-κB Nrf2 signaling pathways in broiler chickens. For experiment, 240 one-day old Cobb chicks were allocated into four dietary treatment...
Bovine endometritis affects milk production and reproductive performance in dairy cows causes serious economic loss. The underlying molecular mechanisms or signaling pathways of ovine remain unclear. In this study, we attempted to determine the expression mechanism mir-223 evaluate its potential therapeutic value. We first confirmed that there was an increased level miR-223 endometritis, then, LPS-induced bovine endometrial epithelial cell (BEND) line used mimic inflammatory model vitro. Our...
Abstract Endometritis is a postnatal reproductive disorder disease, which leads to great economic losses for the modern dairy industry. Emerging evidence indicates that microRNAs (miRNAs) play pivotal role in variety of diseases and have been identified as critical regulators innate immune response. Recent miRNome profile analysis revealed an altered expression level miR‐148a cows with endometritis. Therefore, present study aims investigate regulatory response involved endometritis estimate...
Aflatoxin B₁ (AFB₁) is a serious threat to the poultry industry. Proanthocyanidins (PCs) demonstrates broad range of biological, pharmacological, therapeutic, and chemoprotective properties. The aim this study was investigate ameliorative effects PCs against AFB₁-induced histopathology, oxidative stress, apoptosis via mitochondrial pathway in bursa Fabricius (BF) broilers. One hundred forty-four one-day old Cobb chicks were randomly assigned into four treatment groups six replicates (6 birds...
Deoxynivalenol (DON) is considered to be a grave threat humans and animals. Ginsenoside Rb1 (Rb1) has been reported for its antioxidant potential medicinal properties. However, the shielding effects of precise molecular mechanisms against DON-induced immunotoxicity in mice have not yet. In present research, 4-weeks old healthy C57BL/6 were randomly assigned into four experimental groups (n = 12), viz., CON, DON 3 mg/kg BW, 50 BW + (DON Rb1). Feed intake body weight gain monitored during...
Lumpy skin disease (LSD) is an infectious affecting large ruminants, caused by the lumpy virus (LSDV). It characterized symptoms such as hyperthermia, emaciation, lymphadenopathy, and nodules. Pregnant animals affected LSD often experience abortions may develop infertility syndrome, while males can become sterile. A live attenuated goat pox vaccine (GTPV) was administered to various groups of crossbred buffaloes. After vaccination, blood samples were collected from each group analyze...
Abstract Bovine embryo resorption is one of the key factors restricting reproductive efficiency in dairy cattle, which mainly occurs early stage maternal recognition pregnancy (MRP), causing substantial economic losses to industry. Macrophages, most numerous endometrial immune cells cows during pregnancy, are critical developing maternal-fetal tolerance. However, mechanism their action on interface remains unknown. MicroRNAs have important roles tolerance and macrophage polarization, but...
Icariin (ICA) is a naturally occurring phytochemical agent primarily extracted from Epimedium Brevicornum Maxim (Family Berberidaceae) with broad spectrum of bioactivities. Endometritis uterine disease that causes enormous losses in the dairy industry worldwide. In this study, anti-inflammatory and anti-oxidant properties ICA were investigated against lipopolysaccharide (LPS)-induced endometritis mice to investigate possible underlying molecular mechanisms. Sixty heathy female Kunming...