A5100366313- CRISPR and Genetic Engineering
- Photosynthetic Processes and Mechanisms
- Bacteriophages and microbial interactions
- Parasitic Infections and Diagnostics
- Cytomegalovirus and herpesvirus research
- RNA and protein synthesis mechanisms
- Nanowire Synthesis and Applications
- Amoebic Infections and Treatments
- DNA Repair Mechanisms
- Coccidia and coccidiosis research
- RNA Interference and Gene Delivery
- Antimicrobial Peptides and Activities
- IL-33, ST2, and ILC Pathways
- Long-Term Effects of COVID-19
- Chromatography in Natural Products
- Insect symbiosis and bacterial influences
- Semiconductor materials and interfaces
- Immunodeficiency and Autoimmune Disorders
- Light effects on plants
- Ga2O3 and related materials
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Plant-based Medicinal Research
- Mitochondrial Function and Pathology
- CAR-T cell therapy research
- Antibiotic Resistance in Bacteria
Huazhong Agricultural University
2010-2025
Chinese Academy of Agricultural Sciences
2022-2023
Shanghai Zhangjiang Laboratory
2021-2023
Key Laboratory of Guangdong Province
2023
Agricultural Genomics Institute at Shenzhen
2023
Shanghai Veterinary Research Institute
2022
Huazhong University of Science and Technology
2010-2022
Tongji Hospital
2019-2022
Institute of Bast Fiber Crops
2022
State Key Laboratory of Agricultural Microbiology
2021
Signaling from pathogen sensing to effector activation is a fundamental principle of cellular immunity. While cyclic (oligo)nucleotides have emerged as key signaling molecules, the existence other messengers remains largely unexplored. Here, we reveal bacterial anti-phage system that mediates immune through nucleobase modification. Immunity triggered by phage nucleotide kinases, which, combined with system-encoded adenosine deaminase, produce deoxyinosine 5′-triphosphate (dITP) messengers....
We exploited the oxide shell structure to explore confinement effect on nickel silicide growth in one-dimensional nanowire template. The is similar contact (via hole) thin film system or nanodevices passivated by nitride film. Silicon nanowires direct with pads transform into two phases of silicides, Ni31Si12 and NiSi2, after one-step annealing at 550 °C. In a bare Si during process, NiSi2 grows initially through nanowire, followed transformation nickel-rich phase, starting from near pad....
This study aimed to explore the prevalence of psychological disorders and associated factors at different stages COVID-19 epidemic in China.The mental health status respondents was assessed via Patient Health Questionnaire-9 (PHQ-9), Insomnia Severity Index (ISI) Generalized Anxiety Disorder 7 (GAD-7) scale.5657 individuals participated this study. History chronic disease a common risk factor for severe present depression (OR 2.2, 95% confidence interval [CI], 1.82-2.66, p < 0.001), anxiety...
DNA double-strand breaks (DSBs) are the most toxic form of damage in cells. Homologous recombination (HR) is an error-free repair mechanism for DSBs as well a basis gene targeting using genome-editing techniques. Despite importance HR, HR plants poorly understood. Through genetic screens response mutants (DDRMs), we find that Arabidopsis ddrm2 mutant hypersensitive to DSB-inducing reagents. DDRM2 encodes protein with four BRCA1 C-terminal (BRCT) domains and highly conserved including...
Abstract Bovine embryo resorption is one of the key factors restricting reproductive efficiency in dairy cattle, which mainly occurs early stage maternal recognition pregnancy (MRP), causing substantial economic losses to industry. Macrophages, most numerous endometrial immune cells cows during pregnancy, are critical developing maternal-fetal tolerance. However, mechanism their action on interface remains unknown. MicroRNAs have important roles tolerance and macrophage polarization, but...
Mutations in the PIGV, PIGO, PIGL, PIGY, PGAP2, PGAP3, and PIGW genes have recently been reported to cause hyperphosphatasia accompanied by mental retardation syndrome (HPMRS); latter is an autosomal-recessive neurological disorder typically characterised recurrent seizures, intellectual disability, distinct facial features. Here, we report extremely rare case of a Chinese boy with compound heterozygous mutations who suffers from severe pneumonia, retardation, epilepsy. A 70-day-old...
Signaling from pathogen sensing to effector activation is a fundamental principle of cellular immunity. While cyclic (oligo)nucleotides have emerged as key signaling molecules, the existence other messengers remains largely unexplored. Here, we reveal bacterial anti-phage system that mediates immune through nucleobase modification. Immunity triggered by phage nucleotide kinases, which, combined with system-encoded adenosine deaminase, produce deoxyinosine 5'-triphosphate (dITP) messengers....
Leuchten in wechselnden Farben: Die Expression eines Multigen-Fusionsprodukts aus dem Strukturgen des Apoproteins und den Genen für die Chromophor-Biosynthese endogenem Häm eröffnet einen neuen In-vivo-Zugang zu Biliproteinen. In E. coli wurden dauerhaft fluoreszierende sowie durch Rot-Grün-Belichtung reversibel schaltbare Biliproteine mit gut getrennten Absorptions- Fluoreszenzmaxima der beiden Zustände produziert (siehe Spektren). Detailed facts of importance to specialist readers are...
In the current study, total content from two Apocynum species leaves (Apocynum venetum and hendersonii) collected Ili River Valley Region were extracted, their bioactivities investigated. The results showed a significant variation in flavonoid contents leaf samples at different periods (June, July, August, September), with highest August (60.11 ± 0.38 mg RE/g DW for A. 56.56 0.24 hendersonii), lowest June (22.36 0.05 20.79 0.02 hendersonii). was comparably higher than hendersonii. Leaves...
Summary Argonaute (Ago) proteins are widespread nucleic acid-guided enzymes that recognize targets through complementary base pairing. While in eukaryotes Agos involved RNA silencing, the functions of prokaryotic (pAgos) remain largely unknown. In particular, a clade truncated and catalytically inactive pAgos (short pAgos) lacks characterization. Here, we reveal short pAgo protein Sulfolobus islandicus , together with its two genetically associated proteins, Aga1 Aga2, provide robust...
Until now, no completely effective parasite-specific drugs or vaccines have been approved for the treatment of cryptosporidiosis. Through separation and identification sporozoite membrane protein Cryptosporidium parvum (C. parvum), 20 related proteins were obtained. Among them, a calmodulin-like (CML) has similar functional domain-exchange factor hand (EF-hand) motif as calmodulin (CaMs), so it may play similarly important role in invasion process. A 663 bp full gene encoding C. (CpCML) was...
Abstract DNA double-strand breaks (DSBs) are the most toxic damage for cells. Homologous recombination (HR) is a precise DSB repair mechanism as well basis gene targeting using genome-editing techniques. Despite importance of HR, HR in plants poorly understood. In genetic screen Damage Response Mutants (DDRMs), we find that Arabidopsis ddrm2 mutant hypersensitive to DSB-inducing reagents. DDRM2 encodes protein with four BRCA1 C-terminal (BRCT) domains and highly conserved including earliest...
Summary Argonaute (Ago) proteins are widespread nucleic acid-guided enzymes that recognize targets through complementary base pairing. While in eukaryotes Agos involved RNA silencing, the functions of prokaryotic (pAgos) remain largely unknown. In particular, a clade truncated and catalytically inactive pAgos (short pAgos) lacks characterization. Here, we reveal short pAgo protein Sulfolobus islandicus , together with its two genetically associated proteins, Aga1 Aga2, provide robust...