A5088199873- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Adipose Tissue and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- High Altitude and Hypoxia
- Cell death mechanisms and regulation
- Cancer-related Molecular Pathways
- Parkinson's Disease Mechanisms and Treatments
- Memory and Neural Mechanisms
- Barrier Structure and Function Studies
- Ubiquitin and proteasome pathways
- Stress Responses and Cortisol
- Alzheimer's disease research and treatments
- Mercury impact and mitigation studies
- Neurological Disease Mechanisms and Treatments
- Heavy metals in environment
- Cancer, Hypoxia, and Metabolism
- NF-κB Signaling Pathways
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- Aluminum toxicity and tolerance in plants and animals
- Long-Term Effects of COVID-19
Shenzhen Center for Disease Control and Prevention
2025
Air Force Medical University
2015-2024
Southwest Medical University
2024
Hubei Cancer Hospital
2024
Union Hospital
2020-2024
Huazhong University of Science and Technology
2020-2024
First Affiliated Hospital of Xi'an Jiaotong University
2023
The People's Hospital of Guangxi Zhuang Autonomous Region
2019-2022
Academy of Medical Sciences
2022
General Hospital of Central Theater Command
2020-2021
Central nervous system (CNS) inflammation and autophagy dysfunction are known to be involved in the pathology of neurodegenerative diseases. Manganese (Mn), a neurotoxic metal, has potential induce microglia-mediated neuroinflammation as well dysfunction. NLRP3 (NLR family, pyrin domain containing 3)- CASP1 (caspase 1) inflammasome-mediated microglia specific relevance neurological However, mechanism driving these phenomena remains poorly understood. We demonstrate that Mn activates...
Manganese is an essential trace element required for normal development and bodily functions. However, exposure of the brain to excessive amounts manganese results in neurotoxicity. Although previous studies examining neurotoxicity have focused on neuronal injury, especially direct injury dopaminergic neurons, effects manganese-induced glial cells not been reported. The current study was designed examine effect microglial activation, underlying mechanism vivo. We established animal model...
Cold-inducible RNA binding protein (CIRBP), a stress response protein, protects cells from mild hypothermia or hypoxia by stabilizing specific mRNAs and promoting their translation. Neurons subjected to hypobaric insult trigger various cell death programs. One of these is ferroptosis, novel non-apoptotic form programmed death, which characterized excessive iron ion accumulation lipid peroxidation. Here, we establish that CIRBP can regulate neuronal ferroptosis both in vivo vitro. We observe...
Introduction Cervical cancer is the fourth most commonly diagnosed malignancy among women globally, with HPV infection being primary cause. Large-scale screening crucial for early detection, as appropriate intervention in HPV-positive individuals can significantly reduce cervical incidence and mortality. Methods Data were extracted from Shenzhen Maternal Child Health Management Information System, covering 18,667 instances 15,850 January 1, 2020, to December 31, 2023. prevalence...
Exposure of Lead (Pb), a known neurotoxicant, can impair spatial learning and memory probably via impairing the hippocampal long-term potentiation (LTP) as well neuronal injury. Activation microglia also impairs memory. Thus, we raised hypothesis that activation is involved in Pb exposure induced LTP impairment To test this clarify its underlying mechanisms, investigated Pb-exposure on activation, cytokine release, level injury vivo or vitro model. The changes these parameters were observed...
The etiological role of dysregulated autophagy in neurodegenerative diseases has been a subject intense investigation. While manganese (Mn) is known to cause dopaminergic (DAergic) neurodegeneration, it yet be determined whether the dysregulation plays Mn-induced neuronal injury. In this study, we investigated effect Mn on rat model manganism, disease associated with excessive exposure Mn. After single intrastriatal injection Mn, short- (4-12 h) and long-term (1-28 days) DAergic neurons were...
Abstract We conducted a multicentre cross-sectional survey of COVID-19 patients to evaluate the acute psychological impact on with coronavirus disease 2019 (COVID-19) during isolation treatment based online questionnaires from 2 February 5 March 2020. A total 460 13 medical centers in Hubei province were investigated for their mental health status using (including Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, Questionnaire-15, and Insomnia Severity Index scales). Among all...
X-linked inhibitor of apoptosis protein (XIAP) overexpression has been found to be associated with malignant cancer progression and aggression in individuals many types cancers. However, the molecular basis XIAP regulation cell biological behavior remains largely unknown. In this study, we that a deficiency expression human cells by either knock-out or knockdown leads marked reduction β-actin polymerization cytoskeleton formation. Consistently, migration invasion were also decreased...
Chronic stress is considered to be a major risk factor in the development of psychopathological syndromes humans. Cognitive impairments and long-term potentiation (LTP) are increasingly recognized as components depression, anxiety disorders other stress-related chronic psychological illnesses. It seems timely systematically study potentially underlying neurobiological mechanisms altered cognitive synaptic plasticity course stress. In present study, rat model unpredictable (CUS) induced...
Lead (Pb) is known to impair children's cognitive function. It has been previously shown that developmental Pb exposure alters dendritic spine formation in hippocampal pyramidal neurons. However, the underlying mechanism not yet defined. In this study, a low-level gestational (GLE) rat model was employed investigate impact of on density neurons and its regulatory mechanism. resulted impaired performance rats Morris water maze tasks, decreased EPSC amplitudes CA3-CA1 regions. With 3D...
This study aimed to explore the prevalence of psychological disorders and associated factors at different stages COVID-19 epidemic in China.The mental health status respondents was assessed via Patient Health Questionnaire-9 (PHQ-9), Insomnia Severity Index (ISI) Generalized Anxiety Disorder 7 (GAD-7) scale.5657 individuals participated this study. History chronic disease a common risk factor for severe present depression (OR 2.2, 95% confidence interval [CI], 1.82-2.66, p < 0.001), anxiety...
With the progress of society and economic development, exchanges between countries are becoming more frequent closer, spread diffusion species common, which promotes exchange utilization biological resources, but also inevitably causes problem invasion alien species. The poses a great threat to biodiversity, human health so identification construction risk prevention system particularly important. Therefore, based on definition “biological invasion”, this study analyzes harm invasive...