A5001789877- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Heavy Metal Exposure and Toxicity
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Parkinson's Disease Mechanisms and Treatments
- Noise Effects and Management
- RNA modifications and cancer
- Global Health Care Issues
- Alzheimer's disease research and treatments
- Trace Elements in Health
- Autophagy in Disease and Therapy
- Urban Transport and Accessibility
- Inflammatory mediators and NSAID effects
- Allergic Rhinitis and Sensitization
- Skin Protection and Aging
- NF-κB Signaling Pathways
- Neuroscience and Neuropharmacology Research
- Circadian rhythm and melatonin
- RNA Research and Splicing
- Nanoparticles: synthesis and applications
- Inflammasome and immune disorders
- Circular RNAs in diseases
- Nuclear Receptors and Signaling
- Air Quality Monitoring and Forecasting
Army Medical University
2016-2025
Jiangxi Science and Technology Normal University
2024-2025
Guiyang Medical University
2022-2025
Daping Hospital
2025
First Affiliated Hospital of Jiangxi Medical College
2025
Nanchang University
2024-2025
Chongqing Medical and Pharmaceutical College
2021
Army Medical College
2020
Yunnan Center for Disease Control And Prevention
2017-2018
Air Force Medical University
2007-2017
Central nervous system (CNS) inflammation and autophagy dysfunction are known to be involved in the pathology of neurodegenerative diseases. Manganese (Mn), a neurotoxic metal, has potential induce microglia-mediated neuroinflammation as well dysfunction. NLRP3 (NLR family, pyrin domain containing 3)- CASP1 (caspase 1) inflammasome-mediated microglia specific relevance neurological However, mechanism driving these phenomena remains poorly understood. We demonstrate that Mn activates...
Manganese is an essential trace element required for normal development and bodily functions. However, exposure of the brain to excessive amounts manganese results in neurotoxicity. Although previous studies examining neurotoxicity have focused on neuronal injury, especially direct injury dopaminergic neurons, effects manganese-induced glial cells not been reported. The current study was designed examine effect microglial activation, underlying mechanism vivo. We established animal model...
Lead (Pb) is a well-known heavy metal in nature.Pb can cause pathophysiological changes several organ systems including central nervous system.Especially, Pb affect intelligence development and the ability of learning memory children.However, toxic effects mechanisms on are still unclear.To clarify Pb-induced neurotoxicity hippocampus, its effect memory, we chose Sprague-Dawley rats (SD-rats) as experimental subjects.We used Morris water maze to verify after treatment.We...
The etiological role of dysregulated autophagy in neurodegenerative diseases has been a subject intense investigation. While manganese (Mn) is known to cause dopaminergic (DAergic) neurodegeneration, it yet be determined whether the dysregulation plays Mn-induced neuronal injury. In this study, we investigated effect Mn on rat model manganism, disease associated with excessive exposure Mn. After single intrastriatal injection Mn, short- (4-12 h) and long-term (1-28 days) DAergic neurons were...
Dysregulation of long noncoding RNA (lncRNA) is known to be involved in numerous human diseases, including lung cancer. However, the precise biological functions most lncRNA remain elucidated. Here, we identified a novel up-regulated lncRNA, LINC01436 (RefSeq: NR_110419.1), non-small cell cancer (NSCLC). High expression was significantly associated with poor overall survival. Notably, transcriptionally repressed by E2F6 under normoxia, and inhibitory effect relieved hypoxic microenvironment....
Glutathione (GSH) plays an important role in maintaining REDOX homeostasis biological systems. Development of reliable glutathione sensors is great significance to better understand the biomolecules in...
Myocardial infarction (MI) ranks as one of the primary causes global disabilities and disease deaths. The association between fine particulate matter (PM2.5) MI has gained attention in recent years. In this study, we assessed relationship short-term PM2.5 exposure inpatient hospitalization costs using multiple linear regression, estimated attributable burden. Stratified analyses were done by gender, age, season, hyperlipidemia. economic burden was WHO (25 μg/m³) China's (75 criteria....
ABSTRACT Aims Accurately predicting recompensation in patients with decompensated hepatitis B‐related cirrhosis is crucial for guiding treatment strategies. As a reliable model accurately currently lacking, this study aimed to develop contrast‐enhanced computed tomography (CECT) radiomics specifically assessing outcomes patient population. Methods A retrospective cohort of 218 was included. Patients were randomly divided into training ( n = 152) and testing cohorts 66) at 7:3 ratio by random...
This study aimed to investigate the relationship between dietary intake of total flavonoids and their six subclasses risk atherosclerotic cardiovascular disease (ASCVD) in adults, evaluate potential mediating effect inflammation this association. Cross-sectional data from 3841 individuals participating National Health Nutrition Examination Survey 2017–2018 were included analysis. Flavonoid was assessed using a 2-day recall method, ASCVD status determined by extracting relevant information...
Abstract SFTA1P is a pseudogene-derived lncRNA and has become master regulator in tumor carcinogenesis progression processes. been reported as potential diagnostic prognostic biomarker non-small cell lung cancer (NSCLC). The down-regulation of tissue associated with poor prognosis, however, the detailed molecular mechanism biological functions still need to be investigated. We demonstrated that inhibited growth metastasis NSCLC vitro vivo. played dual cytoplasm nucleus: cytoplasm, can serve...
Manganese has long been known to induce neurological degenerative disorders. Emerging evidence indicates that hyperphosphorylated tau is associated with neurodegenerative diseases, but whether such hyperphosphorylation plays a role in manganese-induced neurotoxicity remains unclear. To fill this gap, we investigated the effects of manganese on phosphorylation PC12 cells. In our present research, treatment cells increased at Ser199, Ser202, Ser396, and Ser404 as detected by Western blot....
The data concerning the association between environmental pollution and epilepsy attacks are limited. aim of this study was to explore acute air exposure attack.A hospital record-based carried out in Xi'an, a heavily-polluted metropolis China. Daily baseline were obtained. Time-series Poisson regression models applied analyze epilepsy.A 10 μg/m3 increase NO2, SO2, O3 concentrations corresponded 3.17% (95%Cl: 1.41%, 4.93%), 3.55% 1.93%, 5.18%), -0.84% -1.58%, 0.09%) outpatient-visits for on...