A5029089540- Multicomponent Synthesis of Heterocycles
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and biological activity
- Quinazolinone synthesis and applications
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis of heterocyclic compounds
- Catalytic C–H Functionalization Methods
- Chemical Synthesis and Reactions
- Radical Photochemical Reactions
- Chemical Synthesis and Analysis
- Sulfur-Based Synthesis Techniques
- Microwave-Assisted Synthesis and Applications
- Synthesis of Organic Compounds
- Synthesis of Indole Derivatives
- Axial and Atropisomeric Chirality Synthesis
- Oxidative Organic Chemistry Reactions
- Fluorine in Organic Chemistry
- Advanced Synthetic Organic Chemistry
- Synthesis and Reactivity of Heterocycles
- Crystallography and molecular interactions
- Asymmetric Hydrogenation and Catalysis
- Bioactive Compounds and Antitumor Agents
Jiangsu Normal University
2015-2024
State Key Laboratory of Synthetic Chemistry
2016
China University of Mining and Technology
2012-2014
Shanghai Institute of Organic Chemistry
2012-2013
Chinese Academy of Sciences
2012
Xuzhou Medical College
2003-2008
Nanjing University
2003
Two birds with one stone: the simultaneous production of two important bulk chemicals, methanol and ethylene glycol, from CO(2) oxide has been achieved under mild conditions by highly efficient homogeneous catalytic hydrogenation carbonate in presence a (PNP)Ru(II) catalyst.
Zwei Fliegen mit einer Klappe: Die gleichzeitige Produktion der beiden wichtigen Grundchemikalien Methanol und Ethylenglycol ausgehend von CO2 Ethylenoxid gelingt unter milden Bedingungen über die hoch effiziente homogenkatalytische Hydrierung Ethylencarbonat in Gegenwart eines (PNP)RuII-Katalysators (siehe Schema). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents peer-reviewed, but not copy-edited or typeset. They made available...
We reported an efficient three-component reaction to access new spiro heterocycles through the annulation reactions of isatins, substituted ureas, and cyclic ketones under normal laboratory conditions, which is another example isatins being used build compounds by ring-opening recyclization processes. The wide range substrates, simple operation, experimental high yields make approach practical value.
A novel strategy for the synthesis of (E)-3-((arylsulfonyl)methyl)-4-substituted benzylidenechromene derivatives via a metal-free radical annulation reaction oxygen-containing 1,7-enynes with thiosulfonates has been developed. The shows broad substrate scope, wide functional group tolerance, and moderate to excellent yields. Moreover, were well driven achieve bifunctionalization oxo-1,7-enynes which derived from aliphatic alkynes. In addition, (E)-configuration products was highly controlled...
A "time-economical" radical cascade cyclization/haloazidation of 1,6-enynes provides a direct approach to access highly functional succinimide compounds. Moderate excellent yields along with Z/E ratio were obtained under the reaction features broad substrate scope, good group tolerance, and mild conditions.
In the present study, environment-friendly visible-light-promoted strategy is used to perform an efficient, simple, and straightforward photocatalytic succinimide derivative synthesis from reaction of 1,6-enynes aryl sulfonyl bromide at room temperature under air ambient conditions. This method features mild conditions, broad substrate scope, high yields, excellent configurational selectivity. addition, all atoms substrates involved in converge product structures, showing a atomic economy....
Abstract Knoevenagel condensation of aromatic aldehydes with active methylene compounds under solvent‐free conditions to synthesize arylidene by grinding in the presence TEBA at room temperature has been described. This method is simple, efficient, and environmentally friendly.
As important substrates for the construction of heterocycles, a simple and efficient approach synthesis 1,4-diones is highly desirable. In this work, novel electrochemical radical reactions enol acetates 1,3-diketones have been developed to successfully achieve 1,4-diketones under catalyst-free oxidant-free conditions. The wide range substrates, good group tolerance, operation process make practical value. Moreover, obtained can be easily further transformed pyrrole furan derivatives.
Quinazolin-4(3H)-ones, 1,2-dihydroquinazolin-4(3H)-ones, 3,4-dihydroquinazolines, imidazo[1,2-c]-quinazolines and 5,6-dihydroimidazo[1,2-c]quinazolines were synthesized by the novel reductive reaction of nitro group, N-H bond ortho-ester, aldehydes or ketones promoted low-valent titanium reagent (TiCl4-Zn system). The structures these compounds characterized elemental analysis, IR 1HNMR spectra further confirmed single crystal X-ray diffraction analysis.
Abstract A range of tetrahydrobenzo[b]pyrans have been synthesized in very good yields under solvent‐free conditions by grinding α‐cyanocinnamonitrils or β‐cyano‐β‐carbethoxy styrene and 5,5‐dimethyl‐1,3‐cyclohexanedione the presence TEBA as catalyst. The short reaction time, cleaner reaction, easy workup make this protocol practical economically attractive.
A novel and efficient electrochemical radical δ-H sulfonylation reaction of para-quinone methides (p-QMs) sodium sulfinates has been achieved under common laboratory conditions. In this strategy, a new C(sp2)–S bond was constructed for the synthesis 4-((aryl,arylsulfonyl)methylene)-2,5-cyclohexadiene derivatives with broad substrate scope, good functional group tolerance, mild Further studies showed that had an excellent regional selectivity.
A novel and facile methodology for the synthesis of sulfonated benzo[b]oxepinone chromane derivatives was reported by reaction propargyl chalcones with arylsulfonyl chloride via radical cascade annulation/sulfonation under laboratory conditions. Readily available chalcones, commercialized chloride, simple conditions make this six(seven)-membered oxygen-containing heterocycles' synthetic strategy more attractive significant application values.
A silver-catalyzed cascade cycloaddition of aza-1,6-enynes, affording multifunctional succimide frameworks initiated by the arylsulfonyl radical addition, has been developed. This process shows mild reaction conditions, excellent structural selectivity, and broad functional group tolerance. In Z/E-isomers can be easily separated, which provides an efficient method for obtaining pure Z/E-configuration products.
Abstract A one-pot three-component condensation of aromatic aldehyde, ketone, and malononitrile leading to an efficient synthesis 2-amino-4,6-diarylbenzene-1,3-dicarbonitrile 1,2-dihydro-2-oxo-4,6-diarylpyridine-3-carbonitrile has been carried out in a mortar just by grinding or heating under solvent-free conditions. Compared with the classical reaction conditions, these new synthetic methods have advantages excellent yields, shorter time, mild
Abstract A facile parallel synthesis of 2‐amino‐4,6‐diarylbenzene‐1,3‐dicarbonitrile derivatives via a one‐pot reaction aromatic aldehydes, ketone, and malononitrile under solvent‐free conditions has been developed. This new protocol the advantages shorter time, higher yields, lower cost, environmental friendliness.
Abstract The efficient and novel method for the synthesis of pyrazolo[3,4‐ b ]pyridine pyrano[2,3‐ c ]pyrazole derivatives from multicomponent reaction aromatic aldehydes (isatins), N ‐methyl‐1‐(methylthio)‐2‐nitroethen‐1‐amine, 3‐aminopyrazole or methyl 3‐hydroxy‐1 H ‐pyrazole‐5‐carboxylate under normal laboratory conditions was reported in this research. advantages research are wide range substrates, high yields, simple operation.
The efficient intermolecular alkoxylation reactions of various enol acetates and different alcohols are developed in the electrochemical process for first time. Enol derived from either aromatic, alkyl, or alicyclic ketones, abundant free directly used this synthetic strategy, make transformation very valuable synthesis application future.
An efficient synthesis of amidated indolo[2,1-a]isoquinolin-6(5H)-ones has been achieved via copper(I)-catalyzed radical carbamylation/cyclization 2-aryl-N-methacryloylindoles with substituted formamides. In this reaction, an isoquinoline ring was constructed by carbamylation a carbon-carbon double bond in 2-arylindoles. This strategy successfully introduces the amide group into indolo[2,1-a]isoquinoline skeleton and advantages such as wide substituent scope, mild reaction conditions, high...
Abstract An efficient and facile synthesis of 2,6-dicyanoanilines via a one-pot reaction aromatic aldehydes, malononitrile, cyclic ketones in the presence NaOH under solvent-free conditions using grinding method has been developed. Compared with classical conditions, new synthetic advantages excellent yields, shorter times, mild conditions.