A5100378018- Protein Hydrolysis and Bioactive Peptides
- Polysaccharides Composition and Applications
- Proteins in Food Systems
- Meat and Animal Product Quality
- Selenium in Biological Systems
- Aquaculture Nutrition and Growth
- Air Quality and Health Impacts
- Aquaculture disease management and microbiota
- Polysaccharides and Plant Cell Walls
- Climate Change and Health Impacts
- RNA modifications and cancer
- Enzyme Production and Characterization
- Microbial Community Ecology and Physiology
- Echinoderm biology and ecology
- Environmental Toxicology and Ecotoxicology
- RNA Interference and Gene Delivery
- Advanced Chemical Sensor Technologies
- Advanced biosensing and bioanalysis techniques
- Asthma and respiratory diseases
- SARS-CoV-2 and COVID-19 Research
- Fermentation and Sensory Analysis
- Biochemical and Molecular Research
- Food Quality and Safety Studies
- Seaweed-derived Bioactive Compounds
- Traditional Chinese Medicine Analysis
Guangxi University
2015-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
State Key Laboratory for Innovation and Transformation of Luobing Theory
2024-2025
Qilu Hospital of Shandong University
2024-2025
Gansu University of Traditional Chinese Medicine
2024-2025
Shenyang Pharmaceutical University
2025
Gansu Provincial Maternal and Child Health Hospital
2019-2024
Institute of Microbiology
2009-2024
National Sun Yat-sen University
2024
Tiande (China)
2024
Hereditary hearing impairment is one of the major and common birth defects in Chinese population. Non-syndromic sensorineural loss (NSHL) most types hereditary impairment. Genotypically phenotypically NSHL extremely heterogenous follow either autosomal dominant or recessive X-linked mode inheritance. Presently, 127 genes have been identified to be associated with both syndromic (NSHL). Here, we studied a family moderate profound The proband 30-year old man. was born normal at age 5-years,...
Scope Sulfated polysaccharide from sea cucumber (SCSP), Stichopus japonicus , has been shown to prevent diverse diseases, but little is known about its effects on obesity and gut microbiota in mice fed a high‐fat diet (HFD). Methods results Diet‐induced obese, BALB/c are an HFD with or without SCSP depolymerized (d‐SCSP, 0.004 kcal g −1 ) for 8 weeks. The show that both d‐SCSP reduce body weight, fat liver hypertrophy, insulin resistance, serum lipid inflammatory cytokine levels HFD‐fed...
Current CRISPR-Cas-based nucleic acid sensing methods relying on the preassembled Cas-crRNA complexes are generally limited to detection of protospacer-adjacent motif (PAM)-containing sequences, and nonspecific backgrounds inevitable. Herein, we propose a new CRISPR-derived microRNA mechanism based rolling circle transcription (RCT)-unleashed self-recruiting crRNA by Cas12a (Cas12a-SCR). In Cas12a-SCR, target can specifically trigger RCT produce long single-strand RNA with numerous pre-crRNA...
Intraneuronal neurofibrillary tangles composed of Tau aggregates have been widely accepted as an important pathological hallmark Alzheimer's disease. A current therapeutic avenue for treating disease is aimed at inhibiting accumulation with small molecules such natural flavonoids. Liquid-liquid phase separation (LLPS) can lead to its aggregation, and then be degraded by autophagy. However, it unclear whether flavonoids modulate the formation phase-separated droplets or promote autophagy...
Developing the in vitro cardiac sensing platform is promising to study physiology, disease mechanisms, drug development, and personalized medicine. Changes electrophysiological activity contractile strength of cardiomyocytes are particularly important for generating accurate platforms. Existing platforms generally have situ capabilities capture changes or mechanical behavior cardiomyocytes. However, still face challenges high-throughput detection simultaneous mechano-electrophysiological...
The CRISPR/Cas12a system exhibits extraordinary capability in the field of biosensing and molecular diagnosis due to its trans-cleavage ability. However, it is still desirable for precise control programmable regulation Cas12a activity promote in-depth studies application expansion Cas12a-based sensing platforms. In this work, we have developed a new robust mechanism by endowing activator with function caging crRNA ingeniously. Specifically, constructed an integrated elongation-caged...
Feather keratin is an underappreciated protein resource of high quality, with limited bioavailability, and it urgently requires eco-friendly methods to enhance its value. Here, we report on the preparation, purification, identification novel peptides antioxidant xanthine oxidase (XOD) inhibitory activities from fermented feather broth, using Bacillus licheniformis 8-4. Two peptides, namely, DLCRPCGPTPLA (DA-12) ANSCNEPCVR (AR-10), displayed remarkable 1,1-diphenyl-2-picrylhydrazyl (DPPH)...
The relationship between psychological stress, altered skin immunity, and autophagy-related genes (ATGs) is currently unclear. Psoriasis a chronic inflammation of unclear etiology that characterized by persistence recurrence. Immune dysregulation emotional disturbances are recognized as significant risk factors. Emerging clinical evidence suggests possible connection anxiety disorders, heightened immune system activation, offering fresh perspective on the initiation psoriasis. aim this study...