A5100635695- Invertebrate Immune Response Mechanisms
- Aquaculture disease management and microbiota
- Aquaculture Nutrition and Growth
- Environmental Toxicology and Ecotoxicology
- Solar Thermal and Photovoltaic Systems
- Epigenetics and DNA Methylation
- Probiotics and Fermented Foods
- solar cell performance optimization
- Immune cells in cancer
- Photovoltaic System Optimization Techniques
- Educational Reforms and Innovations
- Cancer-related gene regulation
- Antimicrobial Peptides and Activities
- Selenium in Biological Systems
- Microbial Inactivation Methods
- Asian Culture and Media Studies
- Physiological and biochemical adaptations
- TGF-β signaling in diseases
- Atherosclerosis and Cardiovascular Diseases
- Immune Response and Inflammation
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- interferon and immune responses
- Immunodeficiency and Autoimmune Disorders
- Fibroblast Growth Factor Research
Wenzhou Medical University
2023-2025
Kunming University of Science and Technology
2021-2025
Zhejiang University
2005-2024
Anhui Medical University
2023
Guangxi University
2023
Chinese University of Hong Kong
2022
University of Hong Kong
2022
Guangzhou University of Chinese Medicine
2021
Southern Medical University
2018-2020
Sun Yat-sen University
2018-2020
Abstract Abnormal activation of the gut mucosal immune system and a highly dysregulated microbiota play essential roles in progression inflammatory bowel disease (IBD). The clinical treatment IBD remains challenging, with first‐line drugs showing limited efficacy significant side effects. A reactive oxygen species (ROS)‐activated CO versatile nanomedicine (CMPs) capable remodeling immune‐microbiota microenvironment via potent anti‐oxidant, anti‐inflammatory, antimicrobial effects is...
The accumulation of tumour-associated macrophages (TAMs) in the hypoxic tumour microenvironment (TME) is associated with malignant progression cancer. However, mechanisms by which TME facilitates TAM infiltration are not fully understood. This study showed that high ZEB1 expression cervical cancer cell islets was positively correlated CD163
To explore the mechanisms through which hypoxic tumor microenvironment (TME) modulates transition of tumor‐associated macrophages (TAMs). The migration ability RAW264.7 was determined by transwell assay. Flow cytometric, western blot and immunofluorescence analyses CD206 further validated M2 polarization macrophages. Immunofluorescence, qRT‐PCR were performed to detect expression neuropilin‐1 (Nrp‐1) carbonic anhydrase IX (CAIX). An intermittent hypobaric hypoxia (IH) animal model...
Accumulating evidence reveals that both inflammation and lymphocyte dysfunction play a vital role in the development of diabetic nephropathy (DN). Hyperoside (HPS) or quercetin-3-O-galactoside is an active flavonoid glycoside mainly found Chinese herbal medicine Tu-Si-Zi. Although HPS has variety pharmacological effects, including anti-oxidative anti-apoptotic activities as well podocyte-protective its underlying anti-inflammatory mechanisms remain unclear. Herein, we investigated...
Abstract Disruption of the intestinal epithelial barrier, driven by imbalances in gut mucosal immunity and microbial homeostasis, is central to onset progression inflammatory bowel disease (IBD). This study introduces a CO‐releasing polyoxometalates (POMs) nanozyme (PMC), synthesized coordinating pentacarbonyl manganese bromide with molybdenum‐based POM nanoclusters. PMC demonstrates targeted accumulation at IBD‐affected sites, efficient scavenging reactive oxygen species (ROS), responsive...
Abstract Background The management of chronic diabetic wounds remains a formidable challenge in clinical practice. Persistent hyperglycemia triggers vasculopathy, neuropathy, and immune dysfunction, critically impeding wound repair. We developed multifunctional hydrogel (DPFI) engineered for sequential therapeutic actions, including antibacterial, anti-inflammatory, antioxidant, pro-vascularization/epithelialization, glycemic-regulating properties, to address these complications. Methods...
A 60-day experiment was carried out to investigate dietary starch levels on growth performance, hepatic glucose metabolism and liver histology of largemouth bass, Micropterus salmoides. Fish (initial weight 22.00 ± 0.02 g) were fed five graded corn (0, 50, 100, 150 200 g/kg). low (0 50 g/kg) showed significantly higher gain than other groups (p < .05). Liver lipid glycogen accumulations induced when 100 g/kg. After 20 days feeding, hexokinase activity mRNA expression decreased in fish g/kg...
The study was conducted to compare and evaluate effects of four different macro-algaes on growth, immune response, intestinal microbiota Litopenaeus vannamei. In the rearing trial 1, shrimp were fed five diets containing sources for 8 weeks, named D1 (without macro-algae), D2 (Porphyra haitanensis), D3 (Undaria pinnatifida), D4 (Saccharina japonica), D5 (Gracilaria lemaneiformis), respectively. Growth performance in diet significantly higher than that control (P < 0.05); however, there is no...
Feather keratin is an underappreciated protein resource of high quality, with limited bioavailability, and it urgently requires eco-friendly methods to enhance its value. Here, we report on the preparation, purification, identification novel peptides antioxidant xanthine oxidase (XOD) inhibitory activities from fermented feather broth, using Bacillus licheniformis 8-4. Two peptides, namely, DLCRPCGPTPLA (DA-12) ANSCNEPCVR (AR-10), displayed remarkable 1,1-diphenyl-2-picrylhydrazyl (DPPH)...
Microbial singlecell Raman spectroscopy (SCRS) has emerged as a powerful tool for label free phenotyping, enabling rapid characterization of microbial diversity, metabolic states, and functional interactions within complex communities. However, high throughput SCRS datasets often contain spectral anomalies from noise fluorescence interference, which obscure signatures hinder accurate classification. Robust algorithms outlier detection ramanome analysis remain underdeveloped. Here, we...
Background The intestinal chronic rejection (CR) is the major limitation to long-term survival of transplanted organs. This study aimed investigate interaction between microbiota and epithelial integrity in transplantation, find out whether fish oil enhances recovery integrity. Methods/Principal Findings luminal mucosal composition CR rats were characterized by DGGE analysis at 190 days after transplant. specific bacterial species determined sequence analysis. Furthermore, changes...
Toll-like receptor 7 (TLR7) is located in the endosomal compartment of immune cells. Signaling through TLR7, mediated by adaptor protein MyD88, stimulates innate system and shapes adaptive responses. Previously, we characterized TLR7 ligands conjugated to protein, lipid, or poly(ethylene glycol) (PEG). Among ligand conjugates, addition PEG chains reduced agonistic potency. PEGs are safe humans widely used for improvement pharmacokinetics existing biologics some low molecular weight...
Cervical cancer is one of the most common gynaecological women and suggested to be modulated by estrogenic signals. G protein‐coupled receptor (GPER), a seven‐transmembrane receptor, has been reported regulate cell proliferation various cancers. But there no study investigating effects GPER on progression cervical cancer. In present study, we revealed for first time that was also highly expressed in human cells. Activation via its specific agonist G‐1 induced G2/M cycle arrest down...
Our study (NCT04800133) aimed to determine the safety and immunogenicity in patients with IEIs receiving a 3-dose primary series of mRNA vaccine BNT162b2 (age 12+) or inactivated whole-virion CoronaVac 3+) Hong Kong, including Omicron BA.1 neutralization, nonrandomized manner. Intradermal vaccination was also studied. Thirty-nine were vaccinated, 16 homologous intramuscular 0.3ml 17 0.5ml CoronaVac. Two received 3 doses intradermal CoronaVac, 4 2 third dose BNT162b2. No concerns identified....
A novel transformation system, in which neither a nonphysiological concentration of Ca2+ and temperature shifts nor electronic shocks were required, was developed to determine whether Escherichia coli is naturally transformable. In the new protocol, E. cultured normally stationary phase then statically at 37 degrees C Luria-Bertani broth. After static culture, occurred bacteria spread on plates. The protein synthesis inhibitor chloramphenicol inhibited this process. need for plated suggests...