A5102830915- X-ray Diffraction in Crystallography
- MicroRNA in disease regulation
- Crystallization and Solubility Studies
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Metal-Organic Frameworks: Synthesis and Applications
- Climate Change and Health Impacts
- Magnetism in coordination complexes
- Air Quality and Health Impacts
- Crystal structures of chemical compounds
- RNA modifications and cancer
- Crystallography and molecular interactions
- Synthesis and biological activity
- Cancer Genomics and Diagnostics
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- Metal complexes synthesis and properties
- Microbial Natural Products and Biosynthesis
- Biochemical and Structural Characterization
- Nitrogen and Sulfur Effects on Brassica
- Extracellular vesicles in disease
- Biological Activity of Diterpenoids and Biflavonoids
- Synthesis of Tetrazole Derivatives
- Advanced biosensing and bioanalysis techniques
- Phagocytosis and Immune Regulation
Peking University
2017-2025
Peking University Cancer Hospital
2017-2025
Harbin Medical University
2024
Second Affiliated Hospital of Harbin Medical University
2024
Southern University of Science and Technology
2020-2023
Jinan University
2020-2023
Southwest Hospital
2018-2023
Army Medical University
2018-2023
Guangzhou Medical University
2022-2023
Air Force Medical University
2023
Analysis of circulating tumor DNA (ctDNA) is emerging as a powerful tool for guiding targeted therapy and monitoring evolution in patients with non-small cell lung cancer (NSCLC), especially when representative tissue biopsies are not available.Here, we have compared the ability four leading technology platforms to detect epidermal growth factor receptor (EGFR) mutations (L858R, exon 19 deletion, T790M G719X) ctDNA from NSCLC patients.Two amplification refractory mutation systems (cobas-ARMS...
A series of novel benzofuran-triazole hybrids was designed and synthesized by click chemistry, their structures were characterized HRMS, FTIR NMR. The in vitro antifungal activity target compounds evaluated using the microdilution broth method against five strains pathogenic fungi. result indicated that exhibited moderate to satisfactory activity. Furthermore, molecular docking performed investigate binding affinities interaction modes between compound N-myristoyltransferase. Based on...
The emergence of Carbapenem-resistant Klebsiella pneumoniae (CRKP) represents a threat to public health. Polymyxin-B is generally considered last-resort antibiotic. In this study, we isolated carbapenem- and polymyxin-B resistant K. phage BL02 for the first time in Southwestern China evaluated its biological characteristics whole-genome sequence. pneumoniae, (CK02), was from blood male with severe septic shock, screened purified hospital sewage. could lyse 40 out 46 CRKP isolates (86.96%)...
A blood-based approach to monitor metastasis and recurrence of esophageal squamous cell carcinoma (ESCC) remains undeveloped. This study aimed establish a dependable model utilizing cfDNA 5-hydroxymethylcytosines (5hmC) signatures detect these conditions in ESCC. The 5hmC-Seal technique was employed generate comprehensive 5hmC profiles from the plasma cell-free DNA (cfDNA) 122 ESCC patients, classified into 72 with metastasis, 50 without 30 recurrence, 92 recurrence. Initial steps involved...
In order to develop novel chemotherapeutic agents with potent anticancer activities, we designed four series of compounds employing hybridization strategy. Twenty dihydroartemisinin-coumarin hybrids, 10a–e, 11a–e, 12a–e, 13a–e, were synthesized via click chemistry in this study and their structures characterized by HRMS NMR. The cytotoxic activities measured MTT assay against three cancer cell lines (HCT-116, MDA-MB-231, HT-29) under normoxic or anoxic conditions, respectively. target...
Background . MicroRNA-202 (miR-202) has been reported to be aberrantly regulated in several cancers. The aim of this study is explore the functional role miR-202 EAC tumor growth. Material and Methods expression was detected by qRT-PCR. TargetScan luciferase reporter assay were used elucidate candidate target gene miR-202. FOXR2 protein level assessed Western blot immunohistochemistry. Survival analysis explored for patients. Results significantly decreased tissues (<mml:math...
Accumulated evidences suggested that microRNAs (miRs) play an important role in non-small cell lung cancer (NSCLC). However, how miRs perform their functions adenocarcinoma stem cells (CSCs) remains unknown. Notably, most studies pay more attention to the effects of miRNAs on metastasis traits whereas growth activities CSCs are rather undervalued. In our report, using A549CD133+cells, we examined inhibitory and underlying mechanisms microRNA-31 (miR-31) CSC-like cells. Initially, determined...
Many studies have shown that downregulated miR-203 level is in a variety of cancers including gastric cancer (GC). However, the precise molecule mechanisms GC not been well clarified. In current study, we investigated biological functions and molecular cell lines. We found tissues Moreover, low was associated with increased expression annexin A4 The invasion EMT cells were suppressed by overexpression miR-203. downregulation promoted cells. Bioinformatics analysis predicted potential target...
Disorders of bone homeostasis are the key factors leading to metabolic disease, such as senile osteoporosis, which is characterized by age-related loss. Bone marrow stromal cells (BMSCs) possess high osteogenic capacity has been regarded a practical approach preventing Previous studies have shown that differentiation ability BMSCs significantly decreased in osteoporosis. Recently, circular RNAs (circRNAs) critical regulators controlling sponging microRNAs (miRNAs). Our study aimed discover...
Summary of main observation and conclusion Benzofuran has antifungal activity as the inhibitor N‐myristoyltransferase. Twenty‐nine novel benzofuran‐semicarbazide hybrids were designed synthesized by principle drug combinationatory. On this basis, benzofuran ring was simplified to a resorcinol structure, sixteen 1,3‐dialkoxybenzene‐semicarbazide synthesized. All structures target compounds characterized HRMS NMR. The in vitro evaluated using microdilution broth method against eight strains...
There are increasing concerns with regard to spontaneous abortion (SAB), the loss of pregnancy without external intervention before 20 weeks gestation, among reproductive-aged women. To date, limited evidence is available concerning association between SAB and air pollutants, especially in developing countries. Daily baseline outpatient data for from January 1, 2014, December 31, 2018 (1826 days) were obtained Chongqing, a metropolis southwest China. The over-dispersed Poisson generalized...
Vascular calcification and aging often increase morbidity mortality in patients with diabetes mellitus (DM); however, the underlying mechanisms are still unknown. In present study, we found that Bcl-2 modifying factor (BMF) BMF antisense RNA 1 (BMF-AS1) were significantly increased high glucose-induced calcified senescent vascular smooth muscle cells (VSMCs) as well artery tissues from diabetic mice. Inhibition of BMF-AS1 reduced senescence VSMCs, whereas overexpression generates opposite...
Factors influencing circulating miRNA as a diagnostic marker of hepatocellular carcinoma (HCC) are still unknown. We used two kits to extract total RNA 90 paired serum and plasma samples volunteers in different statuses including healthy, hepatitis, cirrhosis HCC. U6, miR-183 cel-miR-39 expression levels were detected by qRT-PCR. Calculate was the relative level recovery with 2-∆∆CT method standard curve method, respectively.MiRNeasy Serum/Plasma Kit superior miRcute Isolation quality U6...
Abstract C 30 H N 10 O 12 Zn, triclinic, P 1̅ (no. 2), a = 7.6409(15) Å, b 10.438(2) c 11.246(2) α 90.86(3)°, β 107.87(3)°, γ 100.22(3)°, V 837.8(3) Å 3 , Z 1, R gt (F) 0.0377, wR ref (F 2 ) 0.0819, T 293 K.
The metastatic mechanisms of axillary lymph nodes (ALNs) in triple-negative breast cancer (TNBC) remain unclear. We aimed to identify the potential circRNA regulatory network ALN metastasis.We performed whole transcriptome sequencing (WTS) determine expression profiles RNAs and screen out differentially expressed messenger (DEMs), microRNAs (DEMis), circRNAs (DECs) between ALN-positive ALN-negative TNBC patients. Functional enrichment analysis Kaplan-Meier survival were utilized unearth...
Diabetic neuropathy is the most prevalent complication of diabetes mellitus. Although precise etiology this neurological disorder has yet to be defined, elevated blood glucose promotes anerobic glycolysis; produces excess advanced glycation end-products, many which have a pyrrole structure. Here, we test hypothesis that protein adducts are associated with indices and some clinical features diabetic diffuse neuropathies.We investigated levels plasma adjusted urinary in group elderly persons...