A5039009340- Neurological and metabolic disorders
- Heart Rate Variability and Autonomic Control
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Medicinal Plants and Neuroprotection
- Advanced Glycation End Products research
Shenzhen Center for Disease Control and Prevention
2019-2022
Effective treatment to prevent or arrest the advance of Alzheimer disease (AD) has yet be discovered. We investigated whether OligonolR, an FDA-approved flavanol-rich extract prepared from lychee fruit and green tea, exerted beneficial effects relevant AD in a triple transgenic male mouse model (3×Tg-AD). At 9 months age, untreated 3×Tg-AD mice vs. wild-type (WT) controls displayed cognitive deficits behavioral assays and, at 12 months, elevated levels hippocampal amyloid beta-protein (Aβ),...
Diabetic neuropathy is the most prevalent complication of diabetes mellitus. Although precise etiology this neurological disorder has yet to be defined, elevated blood glucose promotes anerobic glycolysis; produces excess advanced glycation end-products, many which have a pyrrole structure. Here, we test hypothesis that protein adducts are associated with indices and some clinical features diabetic diffuse neuropathies.We investigated levels plasma adjusted urinary in group elderly persons...