A5011444305- Prenatal Screening and Diagnostics
- Gestational Diabetes Research and Management
- Maternal and Perinatal Health Interventions
- Reproductive Biology and Fertility
- Breastfeeding Practices and Influences
- Fetal and Pediatric Neurological Disorders
- Metabolism and Genetic Disorders
- Neonatal and fetal brain pathology
- Mobile Health and mHealth Applications
- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- Global Maternal and Child Health
- Assisted Reproductive Technology and Twin Pregnancy
- Genomic variations and chromosomal abnormalities
- Endometrial and Cervical Cancer Treatments
- Pregnancy and preeclampsia studies
- Traditional Chinese Medicine Studies
- Ovarian function and disorders
- Parvovirus B19 Infection Studies
- Medical Research and Treatments
- Maternal and fetal healthcare
- Infant Nutrition and Health
- Child Nutrition and Water Access
- Gynecological conditions and treatments
- Ectopic Pregnancy Diagnosis and Management
Peking Union Medical College Hospital
2018-2025
Army Medical University
2009-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2024
Huazhong University of Science and Technology
2023
Xinqiao Hospital
2017-2022
Affiliated Hospital of North Sichuan Medical College
2022
Guangzhou Medical University
2020-2022
Southwest Hospital
2009-2021
Xi'an Jiaotong University
2020
Tianjin Children's Hospital
2016-2019
Background In the context of aging and digitalization, development application digital health can help meet growing needs older adults. Improving literacy adults may be an effective way to alleviate shortage public resources improve their health-related quality life (HRQoL). However, impact on HRQoL in underlying mechanism remain unclear. This study intends explore whether has effect community-dwelling adults, health-promoting lifestyle plays a mediating role between HRQoL, while providing...
Objectives To evaluate the placental vascular architecture using MV Flow™ imaging for analyzing distribution per region of biological tissue in isolated congenital heart diseases (CHD), CHD associated with extracardiac malformations (EXM) and normal pregnancies, to explore relationship fetal Doppler flow parameters growth perfusion these conditions. Methods Placental microvascular structure was assessed MV‐Flow™ a total 227 fetuses 139 CHD; gestational age ranging from 11 41 weeks were...
We aimed to investigate the value of exome sequencing (ES) in fetuses with callosal anomalies (CA) or without other structural anomalies, but normal findings by karyotyping and chromosome microarray analysis (CMA).Cases CA were screened for eligibility. Fetuses abnormal CMA results excluded. performed ES on DNA samples from eligible fetus-parental trios identified diagnostic genetic variants based ultrasonographic features.A total 50 successfully analyzed ES. found 17 likely pathogenic 14...
Diabetic nephropathy (DN) is a serious metabolic disease, and comprehensive understanding of its complex mechanism will help in preventing the onset progression DN. To reveal systemic changes associated with renal injury, we performed 1H NMR-based metabonomic multivariate analyses to analyze serum urine obtained from nonhuman primate model Our results indicated that DN monkeys exhibited distinct profile, including higher levels VLDL/LDL, lipids, unsaturated uric acid, allantoin, fumarate...
To assess the correlation between Z-scores of positive noninvasive prenatal testing (NIPT) results and predictive value (PPV) NIPT.Pregnancies with NIPT at Guangzhou Women Children's Medical Centre July 2017 May 2020 were included in this study. Fetal karyotyping or microarray analysis was provided to patients abnormal for confirmatory testing. Logistic regression analyses applied study relationship Z scores PPV performance. The optimal cutoff values indicating fetal common trisomies...
To investigate the changes of serum cystatin C (Cys-C), beta 2-microglobulin (β2-MG), urinary neutrophil gelatinase-associated lipocalin (NGAL), and alpha 1-microglobulin (α1-MG) in asphyxiated neonates, to evaluate value combined detection multiple biomarkers early diagnosis acute kidney injury (AKI) neonates.A total 110 full-term 30 healthy neonates were included. The asphyxia divided into AKI non-AKI groups. Serum Cys-C, β2-MG, urine NGAL, α1-MG measured 24 h after birth. diagnostic was...
Cancer stem cells (CSCs) are a group of which possess the ability self-renewing and unlimited proliferation. And these CSCs thought to be cause metastasis, recurrence resistance. Recent study has found that pro-inflammatory cytokine chemotactic factor mediate differentiation most CSCs. Thus we speculate ovarian cancer (OCSCs) can also maintain by releasing inflammatory factor. This report discuss biological characteristics specific molecular mechanism mediated interleukin-23 (IL-23) its...
Regulator of G‑protein signaling 5 (RGS5), a tissue‑specific signal‑regulating molecule, plays key role in the development vasculature. It was recently found that RGS5 is abundantly expressed epithelial ovarian cancer (EOC) compared with normal ovaries. However, distribution EOC and its significance require further investigation. The aim present study to investigate expression EOC, as well association differentiation, metastasis clinicopathological parameters. Immunohistochemistry (IHC),...
The aim of this study was to estimate the effects maternal text messages on inappropriate weight for gestational age (IWGA) in newborns rural China. Participants were pregnant women presenting antenatal care at a Maternal and Child Health Center Xi'an, China during 2013-2015 period. In total, 2115 completed program with follow-up information included final analyses. All mothers divided into four groups, including (1) control group that received only few "Basic" messages, (2) Care-Seeking...
Abstract Objective To assess the value of chromosome microarray analysis (CMA) and whole exome sequencing (WES) in fetuses with cerebellar vermis defects (CVD). Methods From 2013 to 2019, we performed CMA on 43 CVD, who were divided into hypoplasia (CVH) group Dandy‐Walker malformation (DWM) according morphological subtypes. Subsequently, WES was 19 normal results identify diagnostic genetic variants (DGVs). Results Chromosome aneuploidies clinically significant copy number identified 23.3%...
<b><i>Objective:</i></b> The aim of our study was to assess the effects altered salt and potassium intake on urinary renalase serum dopamine levels in humans. <b><i>Methods:</i></b> Forty-two subjects (28-65 years age) were selected from a rural community of<b> </b>northern China. All sequentially maintained low-salt diet for 7 days (3.0 g/day NaCl), high-salt an additional (18.0 with supplementation final NaCl + 4.5 KCl)....
With its huge ageing population, China faces an enormous challenge for elderly support and care. One of the proposed solutions was to diversify systems. Towards this goal, setting up Elderly Care Departments in community health service centres is one such new Chinese endeavour. This qualitative study conducted among residents enrolled existing established at Chongqing, a Southwestern city, evaluate lived experience find strategies improvement. Eighteen participants were recruited from three...
We examined the predictive macrosomia birthweight thresholds for adverse maternal and neonatal outcomes.This was a multicenter, retrospective cohort study conducted in China. selected 178 709 singletons weighing ≥2500 g with gestational age 37-44 weeks. categorized two gradations (4000-4499 ≥4500 g) compared them normosomic reference group of infants 2500-3999 g.The risks obstetric complications increased when had ≥4000 g. The rates infant mortality, Apgar score ≤3 at 5 min, respiratory...
Previous studies using mouse liver tumor models have indicated that coexpression of CD38 and CD101 in programmed cell death-1 (PD-1)+CD8+ T cells may reflect fixed dysregulation CD8+ thus indicate a poor response to anti-PD-1 immunotherapy. However, whether expression PD-1+CD8+ can predict the clinical status efficacy chemotherapy for various cancer types, including ovarian (OC), remains unclear. In present study, peripheral blood mononuclear (PBMCs) were obtained by Ficoll-Hypaque gradient...
Abstract Objective To describe the characteristics of children and adolescents with borderline ovarian tumors (BOTs) evaluate efficacy safety fertility-sparing surgery (FSS) in these patients. Methods Patients BOTs younger than 20 years who underwent FSS were included this study. Results A total 34 patients included, a median patient age 17 (range, 3–19) years; 97.1% (33/34) cases occurred after menarche. Of patients, 82.4% had mucinous (MBOTs), 14.7% serous (SBOTs), 2.9% seromucinous tumor...
Objectives: To investigate changes of cognitive performances in female elderly patients with osteoporosis and to determine whether any impairments can be attributed dysregulation the hypothalamic–pituitary–adrenal (HPA) axis.Methods: This cross-sectional study included 277 postmenopausal women, who were divided into an group (n = 170) age, gender educational history matching control 107). All subjects completed a set neuropsychological tests for assessment, which measures executive function,...
There are increasing concerns with regard to spontaneous abortion (SAB), the loss of pregnancy without external intervention before 20 weeks gestation, among reproductive-aged women. To date, limited evidence is available concerning association between SAB and air pollutants, especially in developing countries. Daily baseline outpatient data for from January 1, 2014, December 31, 2018 (1826 days) were obtained Chongqing, a metropolis southwest China. The over-dispersed Poisson generalized...
To report the frequency of maternal mosaicism contributing to false-positive chromosome X loss associated with noninvasive prenatal testing (NIPT) at a single center.Pregnancies undergone NIPT using massively parallel sequencing Guangzhou Women and Children's Medical Center between February 2015 May 2020 were included in this study. Fetal karyotyping, quantitative fluorescence PCR (QF-PCR) or microarray analysis was provided patients abnormal sex chromosomal aneuploidy (SCA) results for...