A5028964836- Multiple Sclerosis Research Studies
- Acute Ischemic Stroke Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Peripheral Neuropathies and Disorders
- Neurogenesis and neuroplasticity mechanisms
- Systemic Lupus Erythematosus Research
- Mesenchymal stem cell research
- Autoimmune Neurological Disorders and Treatments
- Immune Response and Inflammation
- Neurological Disease Mechanisms and Treatments
- Hereditary Neurological Disorders
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Myasthenia Gravis and Thymoma
- Lung Cancer Treatments and Mutations
- Diabetic Foot Ulcer Assessment and Management
- PI3K/AKT/mTOR signaling in cancer
- Intracerebral and Subarachnoid Hemorrhage Research
- Pain Mechanisms and Treatments
- interferon and immune responses
- Antiplatelet Therapy and Cardiovascular Diseases
- Botulinum Toxin and Related Neurological Disorders
- Genetic Neurodegenerative Diseases
- Venous Thromboembolism Diagnosis and Management
- Inflammasome and immune disorders
Shanghai Jiao Tong University
2016-2025
Renji Hospital
2016-2025
Punan Hospital
2024-2025
Shandong University
2024
Anhui Medical University
2024
Second Military Medical University
2006-2023
Changhai Hospital
2006-2023
Neurology, Inc
2022
Tongji University
2021
Tongji Hospital
2021
Abstract Aims Accumulating evidence has suggested that airborne fine particulate matter (PM2.5) exposure is associated with an increased risk of ischemic stroke. However, the underlying mechanisms have not been fully elucidated. In this study, we aim to investigate role and NLRP3 inflammasome pyroptosis in stroke after PM2.5 exposure. Methods The BV‐2 HMC‐3 microglial cell lines were established subjected oxygen–glucose deprivation reoxygenation (OGD/R) or without We used CCK‐8 assay explore...
Timely screening of neuromyelitis optica spectrum disorder (NMOSD) and differential diagnosis from myelin oligodendrocyte glycoprotein associated (MOGAD) are the keys to improving quality life patients. Metabolic disturbance occurs with development NMOSD. Still, advanced tools required probe metabolic phenotype Here, we developed a fast nanoparticle-enhanced laser desorption/ionization mass spectrometry assay for multiplexing fingerprints (MFs) trace plasma cerebrospinal fluid (CSF) samples...
Small extracellular vesicles (sEVs) derived from M2 microglia (M2-microglia-derived small [M2-sEVs]) contribute to central nervous system repair, although the underlying mechanism remains unknown. In this study, we aimed identify through which microRNA-124 (miR-124) carried in sEVs promotes neural stem cell (NSC) proliferation and neuronal differentiation ischemic mouse brain.M2-sEVs with or without miR-124 knockdown were injected intravenously for 7 consecutive days after transient middle...
Intensity-modulated radiotherapy (IMRT) is the main salvage treatment for advanced locally recurrent nasopharyngeal carcinoma (NPC); however, survival outcomes vary. We aimed to construct a prognostic-score model identify patients who could benefit from IMRT.This retrospective study involved 251 with NPC. The following parameters were analysed IMRT: patient performance status, age, gender, late complications, T-stage of recurrence, synchronous nodal primary gross tumour volume (GTV-nx),...
Iron deposition in the brain is an early issue Alzheimer's disease (AD). However, pathogenesis of iron-induced pathological changes AD remains elusive. Insulin resistance brains essential feature AD. Previous studies determined that insulin involved development pathologies Tau pathology one most important hallmarks and associated with impairment cognition clinical grades disease. In present study, we observed ferrous (Fe2+) chloride led to aberrant phosphorylation tau, decreased tyrosine...
Abstract Aims Activated microglia have been found in the forebrains and hippocampi of temporal lobe epilepsy (TLE) patients status epileptic (SE) animal models. The peroxisome proliferator‐activated receptor γ (PPAR γ) agonist rosiglitazone has shown to prevent microglial activation. However, its role pilocarpine‐induced epilepticus remains unknown. We aimed examine effect PPAR protecting against resulting from over‐activation explore phenotypic changes as underlying mechanism. Methods Male...
The crystal structure of the dimeric gene V protein bacteriophage f1 was determined using multiwavelength anomalous diffraction on selenomethionine-containing wild-type and isoleucine-47-->methionine mutant proteins with x-ray data phased to 2.5 A resolution. has been refined an R factor 19.2% native 1.8 used obtain a model for portion protein-single-stranded DNA complex.
Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are marked by inflammatory demyelinating lesions throughout the central nervous system, including optic nerve. Neuronal loss also occurs in MS EAE lesions, but it is not known whether neuronal secondary to inflammation, or as a primary process. In current study, relationship of inflammation retinal ganglion cell (RGC) during acute neuritis examined. RGCs were labelled with Flourogold, was induced...
Early identification of patients with bipolar disorder during their first depressive episode is beneficial to the outcome and treatment, but traditionally this has been a great challenge clinicians. Recently, brain-derived neurotrophic factor (BDNF) suggested be involved in pathophysiology major (MDD), it not clear whether BDNF levels can used predict among episode.To explore differentiate between MDD episode.A total 203 as well 167 healthy controls were recruited. After 3 years bi-annual...
The association between BDNF gene functional Val66Met polymorphism rs6265 and the schizophrenia is far from being consistent. In addition to heterogeneous in per se leading inconsistent results, interaction among multi-genes probably playing main role pathogenesis of schizophrenia, but not a single gene. Neurotrophic tyrosine kinase receptor 2 (NTRK2) high-affinity BDNF, was reported be associated with mood disorders, though no literature schizophrenia. Thus, present study, total 402...
T-helper 17 (Th17) cells play an important role in the pathogenesis of multiple sclerosis (MS), autoimmune demyelinating disease that affects CNS. In present study, MicroRNA sequencing (miRNA-seq) was performed mouse Th0 and Th17 to determine critical miRNAs are related differentiation. We found miR-30a significantly downregulated during addition, level CD4<sup>+</sup> T from peripheral blood MS patients experimental encephalomyelitis (EAE) animal models also decreased inversely correlated...
Abstract Introduction Neuromyelitis optica spectrum disorders (NMOSD), mainly mediated by B cells and AQP4 antibody, has a high rate of recurrence. Telitacicept is novel drug specifically targeting the upstream signaling for activation cell with its following production autoimmune antibodies. Thus, it may be promising approach. Our study preliminarily explored potential safety effectiveness plasma exchange in treatment recurrent NMOSD. Methods This was single‐center, single‐arm, open‐label...
Background: Patients who experienced an ischemic stroke are at risk for cognitive impairment. Quantified Ginkgo biloba extract EGb 761® has been used to treat dysfunction, functional impairment and neuropsychiatric symptoms in mild dementia. Objectives: To assess the cognitive-related effects of treatment patients after acute stroke, as well feasibility patient selection outcome measures. Methods: We conducted a randomized, multicentric, open-label trial 7 centers China. scoring 20 or lower...