A5101907425- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Diet and metabolism studies
- Functional Brain Connectivity Studies
- Inflammation biomarkers and pathways
- Neuroscience and Neural Engineering
- Advanced Neuroimaging Techniques and Applications
- Peroxisome Proliferator-Activated Receptors
- Extracellular vesicles in disease
- Anesthesia and Neurotoxicity Research
- Neurological Disorders and Treatments
- Nitric Oxide and Endothelin Effects
- Neurological Disease Mechanisms and Treatments
- Immune cells in cancer
- Plant-based Medicinal Research
- Machine Learning in Bioinformatics
Renji Hospital
2019-2024
Shanghai Jiao Tong University
2024
Shanxi Medical University
2021
Shanxi Fenyang Hospital
2021
The ischemic stroke is a major global health concern, with high mortality and disability rates. Unfortunately, there dearth of effective clinical interventions for managing poststroke neuroinflammation blood–brain barrier (BBB) disruption that are crucial the brain injury evolving neurological deficits. By leveraging pathological progression an stroke, we developed M2 microglia-targeting lipid nanoparticle (termed MLNP) approach can selectively deliver mRNA encoding phenotype-switching...
Abstract Aims Activated microglia have been found in the forebrains and hippocampi of temporal lobe epilepsy (TLE) patients status epileptic (SE) animal models. The peroxisome proliferator‐activated receptor γ (PPAR γ) agonist rosiglitazone has shown to prevent microglial activation. However, its role pilocarpine‐induced epilepticus remains unknown. We aimed examine effect PPAR protecting against resulting from over‐activation explore phenotypic changes as underlying mechanism. Methods Male...