A5057541105- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Photocatalysis Techniques
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Supercapacitor Materials and Fabrication
- Angiogenesis and VEGF in Cancer
- Peripheral Artery Disease Management
- Bone Tissue Engineering Materials
- Advanced Sensor and Energy Harvesting Materials
- Calcium Carbonate Crystallization and Inhibition
- Carbon and Quantum Dots Applications
- Dental materials and restorations
- Electrocatalysts for Energy Conversion
- Microstructure and mechanical properties
- Macrophage Migration Inhibitory Factor
- Luminescence and Fluorescent Materials
- Advanced materials and composites
- Mesenchymal stem cell research
- Extracellular vesicles in disease
- Copper-based nanomaterials and applications
- MXene and MAX Phase Materials
- 2D Materials and Applications
- Venous Thromboembolism Diagnosis and Management
- Nuclear Receptors and Signaling
- Conducting polymers and applications
Northwest Institute of Mechanical and Electrical Engineering
2025
Northwest A&F University
2025
Beihang University
2015-2025
Shanghai Jiao Tong University
2019-2025
Shanghai Ninth People's Hospital
2019-2025
Beijing Advanced Sciences and Innovation Center
2024-2025
Renji Hospital
2021-2024
Jiangnan University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Peking Union Medical College Hospital
2022-2024
The ischemic stroke is a major global health concern, with high mortality and disability rates. Unfortunately, there dearth of effective clinical interventions for managing poststroke neuroinflammation blood–brain barrier (BBB) disruption that are crucial the brain injury evolving neurological deficits. By leveraging pathological progression an stroke, we developed M2 microglia-targeting lipid nanoparticle (termed MLNP) approach can selectively deliver mRNA encoding phenotype-switching...
Abstract Two‐dimensional (2D) nanomaterials show unique electrical, mechanical, and catalytic performance owing to their ultrahigh surface‐to‐volume ratio quantum confinement effects. However, ways simply synthesize 2D metal oxide nanosheets through a general facile method is still big challenge. Herein, we report generalized strategy large‐size ultrathin by using graphene (GO) as template in wet‐chemical system. Notably, the novel mainly relies on accurately controlling balance between...
Macrophage migration inhibitory factor (MIF) is a multifaced protein that plays important roles in multiple inflammatory conditions. However, the role of MIF endothelial cell (EC) death under condition remains largely unknown. Here we show actively promotes receptor-interacting kinase 1 (RIPK1)-mediated oxygen-glucose deprivation condition. expression induced by surgical trauma peripheral myeloid cells both perioperative humans and mice. We demonstrate MIF-loaded surgery adhere to brain ECs...
It becomes increasingly important to develop integrated systems with the aim of achieving maximum functionality for state‐of‐the‐art electronic devices. Here, a flexible electrical cable is reported by incorporating biomaterials based fiber supercapacitors into resistor–capacitor circuit. In this unique configuration, electrodes are alternately winded along twisted electric wires, which worked not only as scaffolding support and strengthen slight but also separators spatially confine them...
ConspectusAmorphous nanomaterials, with unique structural features such as long-range atomic disorder and nanoscale particle or grain sizes, possess some advantageous properties for a number of materials applications. For example, amorphous vanadium oxide exhibits record-high cycling stability supercapacitors. Several synthetic strategies have been developed to produce physical processing-based approaches including cutting, deposition, spinning, well chemical syntheses by solution solid...
Ceramic materials exhibit very high stiffness and extraordinary strength, but they typically suffer from brittleness. Amorphization size confinement are commonly used to reinforce materials. However, the inverse Hall-Petch effect shear-band softening usually limit further improvement of their performance under a critical size. With an optimum structure design, we demonstrate that dual-phase zirconia nanowires (DP-ZrO2 NWs) with nanocrystals embedded in amorphous matrix as strengthening phase...
To investigate the impacts of vegetation change on deep soil water recharge, it is essential to identify sources and drainage. The combination stable radioactive isotopes an effective method for studying vadose zones, though has been rarely applied in complex gully areas. In this study, we measured δ2H, δ18O, 3H under long-term natural grassland C. korshinskii same slope. Both plots received from rainfall during rainy season; however, replenishment thresholds at depths 2–10.4 m differed...
Abstract Human tooth enamel, consisting of hydroxyapatite nanocrystals (∼85–88 vol%), proteins (∼2‐3 and requisite water (∼10–12 is 1–3 mm thick at the outer layer tooth. It possesses remarkable properties such as high stiffness, hardness, strength, viscoelasticity. However, when enamel undergoes deterioration due to various factors, including unhealthy dietary habits, wear tear others, it progresses from surface stains loss, ultimately necessitating entire replacement. This because lacks...
Tooth enamel, the outer shell of tooth measuring several millimeters, is hardest tissue human body to masticate food and protect inner dentin. The all-around mechanical properties multiscale-oriented aligned nanoprism structure enamel have attracted wide interests from both clinical applications materials scientists. Here, we focus on analyzing structure-property relationship summarize tooth-enamel analogs based detailed mimicking their hierarchy. underlying principles relating formation...
The metabolic reprogramming of peripheral CD4+ T cells that occurs after stroke can lead to imbalanced differentiation cells, including regulation and presents a promising target for poststroke immunotherapy. However, the regulatory mechanism underlying cell remains unknown. In this study, using combined transcription metabolomics analyses, flow cytometry, conditional knockout mice, we demonstrate receptor advanced glycation end products (RAGE) relay ischemic signal which underwent acetyl...
tRNA-derived fragments (tRFs) are a new class of non-coding RNAs involved in variety pathological processes, but their biological functions and mechanisms human aortic smooth muscle cells (HASMCs) phenotype transition vascular intimal hyperplasia unclear.tiRNA-Gly-GCC is upregulated synthetic HASMCs, atherosclerotic arteries, plasma, the balloon injured carotid artery rats. Functionally, inhibition tiRNA-Gly-GCC represses HASMCs proliferation, migration, reversed dedifferentiation, whereas...
Abstract Two‐dimensional (2D) nanomaterials show unique electrical, mechanical, and catalytic performance owing to their ultrahigh surface‐to‐volume ratio quantum confinement effects. However, ways simply synthesize 2D metal oxide nanosheets through a general facile method is still big challenge. Herein, we report generalized strategy large‐size ultrathin by using graphene (GO) as template in wet‐chemical system. Notably, the novel mainly relies on accurately controlling balance between...
Abstract Dispersible and functionalizable long persistent luminescent (LPL) materials are highly desired for flexible use of LPL in various fields. However, synthesizing metal‐free systems with stable long‐lived intermediates reactive surface groups, which key requirements robust the ability to be functionalized, has proven challenging. Herein, microwave‐assisted preparation carbon dots (CDs)‐based is demonstrated abundant amino groups via situ embedding CDs into nitrides (CNs). The...
Tooth enamel, and especially the outer tooth is a load-resistant shell that benefits mastication but easily damaged, driving need for enamel-restorative materials with comparable properties to restore function protect teeth. Synthesizing an enamel analog mimics components hierarchical structure of natural promising way achieve these mechanical properties, it still challenging realize. Herein, we fabricate stiffness, hardness, viscoelasticity as by incorporating three hierarchies based on...
Ischemic stroke results in blood-brain barrier (BBB) disruption, during which the reciprocal interaction between ischemic neurons and components of BBB appears to play a critical role. However, underlying mechanisms for protection remain largely unknown. In this study, we found that Serpina3n, serine protease inhibitor, was significantly upregulated brain, predominantly from 6 hours 3 days after stroke. Using neuron-specific adeno-associated virus (AAV), intranasal delivery recombinant...