A5101835313- RNA Interference and Gene Delivery
- Advanced Battery Materials and Technologies
- Advancements in Battery Materials
- Extracellular vesicles in disease
- Cardiac Fibrosis and Remodeling
- Pulsed Power Technology Applications
- Immune cells in cancer
- Plasma Diagnostics and Applications
- Extraction and Separation Processes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Atherosclerosis and Cardiovascular Diseases
- Hydrogels: synthesis, properties, applications
- Nuclear Receptors and Signaling
- Quantum Information and Cryptography
- Cervical Cancer and HPV Research
- Pressure Ulcer Prevention and Management
- Medical Research and Treatments
- Mesenchymal stem cell research
- Gyrotron and Vacuum Electronics Research
- Endometrial and Cervical Cancer Treatments
- Protease and Inhibitor Mechanisms
- Signaling Pathways in Disease
- Diabetic Foot Ulcer Assessment and Management
- Occupational exposure and asthma
- Electrostatic Discharge in Electronics
Nanjing Tech University
2025
Shanghai Jiao Tong University
2018-2024
Kunming Medical University
2023
Northwest Institute of Nuclear Technology
2023
University of Science and Technology of China
2021
Ruijin Hospital
2020
Heilongjiang Institute of Technology
2011
Prolonged, intense inflammation and excessive oxidative stress hinder diabetic wounds from healing normally, leading to disorders downstream including the postponement of re-epithelialization extracellular matrix (ECM) formation. Herein, we report a hyaluronic acid (HA) chitosan based hydrogel (OHA-CMC) with inherent antibacterial hemostatic activities fabricated via Schiff base reaction. By encapsulating nanotechnologically-modified curcumin (CNP) epidermal growth factor (EGF) into...
Interleukin-11 (IL-11) is a profibrotic cytokine essential for the differentiation of fibroblasts into collagen-secreting, actin alpha 2, smooth muscle-positive (ACTA2+) myofibroblasts, driving processes underlying pathogenesis idiopathic pulmonary fibrosis (IPF). Here, we developed an inhalable and mucus-penetrative nanoparticle (NP) system incorporating siRNA against IL11 (siIL11@PPGC NPs) investigated therapeutic potential treatment IPF. NPs are formulated through self-assembly...
The ischemic stroke is a major global health concern, with high mortality and disability rates. Unfortunately, there dearth of effective clinical interventions for managing poststroke neuroinflammation blood–brain barrier (BBB) disruption that are crucial the brain injury evolving neurological deficits. By leveraging pathological progression an stroke, we developed M2 microglia-targeting lipid nanoparticle (termed MLNP) approach can selectively deliver mRNA encoding phenotype-switching...
Ionizable cationic lipid-containing lipid nanoparticles (LNPs) are the most clinically advanced non-viral gene delivery platforms, holding great potential for therapeutics. This is exemplified by two COVID-19 vaccines employing mRNA-LNP technology from Pfizer/BioNTech and Moderna. Herein, we develop a chemical library of ionizable lipids through one-step chemical-biological enzyme-catalyzed esterification method, synthesized were further prepared to be LNPs mRNA delivery. Through orthogonal...
Atherosclerosis is a common pathology present in many cardiovascular diseases. Although the current therapies (including statins and inhibitors of serine protease PCSK9) can effectively reduce low-density lipoprotein (LDL) cholesterol levels to guideline-recommended levels, major adverse events still occur frequently. Indeed, subendothelial retention lipoproteins artery wall triggers multiple inflammation macrophages contributor pathological progression atherosclerosis. It has been gradually...
Implanted medical biomaterials are closely in contact with host biological systems via biomaterial–cell/tissue interactions, and these interactions play pivotal roles regulating cell functions tissue regeneration. However, many degrade over time, degradation products also have been shown to interact cells/tissue. Therefore, it may prove useful specifically design implanted which greatly improve the performance of implant. Herein, we report an injectable, citrate-containing polyester hydrogel...
Background NCOR1 (nuclear receptor corepressor 1) is an essential coregulator of gene transcription. It has been shown that in macrophages plays important roles metabolic regulation. However, the function macrophage response to myocardial infarction (MI) or vascular wire injury not elucidated. Methods and Results Here, using Ncor1 knockout mouse combination with a model MI, we demonstrated deficiency significantly reduced infarct size improved cardiac after MI. In addition, markedly...
By describing the gas breakdown phenomenon from view of probability density function (pdf) estimation, a numerical calculation model is proposed to apply for design 1 + n-type multistage spark switch (GSS). The physical principle, model, procedures, and experimental test GSS are hence described in considerable detail text. Various key operating parameters GSS, that is, nontrigger rate <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">...
Objective: To investigate the effects of hypoxia-pretreated rat adipose-derived mesenchymal stem cells (ADSCs) conditioned medium on wound healing rats with full-thickness defects. Methods: (1) A 6-week-old male Sprague-Dawley was sacrificed by cervical dislocation, bilateral inguinal adipose tissue collected, third generation ADSCs were isolated collagenase digestion method, and morphology observed. The harvested divided into adipogenic induction group osteogenic according to random number...
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As one of the regulators cationic concentration in cells, potassium channels play an important role depolarization and repolarization nerve cell. KcsA (K<sup>+</sup> conduction selectivity architecture) channel is simple has commonness ion channel, which often used as a template for research. In this paper, Brownian dynamics (BD) method to simulate electrical characteristics actual systematically. The potential mean force (PMF) ions under electrostatic field, current-voltage...
Abstract This paper presents the development of a novel megavolt-class equal breakdown probability (EBP) multi-stage self-discharge gas switch for high power microwave generation with low jitter and reliability. With joint distribution ‘n’ identical stages EBP switch, advantages diminishing omitting complex order problem are hence disclosed in considerable details aid computation method. Based on theoretical analysis, 5 1-MV is designed which periodic cog profile cathode proposed to further...
The aim of this study was to explore the correlation and difference influencing factors by analyzing psychological status patients with cervical precancerous lesions cancer in Han Ethnic minorities. So as provide evidence for more targeted intervention categories types patients.The Chinese version Kessler 10 scale used investigate 200 100 ethnic minority Yunnan Cancer Center. Statistical analysis performed using t-test, variance, multivariable linear regression.There no significant...
Objective: The aim of this study was to explore the correlation and difference influencing factors by analyzing psychological status patients with cervical precancerous lesions cancer in Han Ethnic minorities. So as provide evidence for more targeted intervention categories types patients. Methods: 200 100 minority Yunnan center were investigated Chinese version Kessler 10 Scale. Statistical analysis performed using t-test, variance, multivariable linear regression. Results: There no...