A5045061140- Acute Myeloid Leukemia Research
- Genomics and Phylogenetic Studies
- Mesenchymal stem cell research
- Histone Deacetylase Inhibitors Research
- Cancer, Hypoxia, and Metabolism
- Ear Surgery and Otitis Media
- Echinoderm biology and ecology
- Marine Bivalve and Aquaculture Studies
- Immune Response and Inflammation
- Anesthesia and Neurotoxicity Research
- Multiple Myeloma Research and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- Reconstructive Facial Surgery Techniques
- Sarcoidosis and Beryllium Toxicity Research
- Phagocytosis and Immune Regulation
- Spondyloarthritis Studies and Treatments
- Advanced Image Fusion Techniques
- Structural Integrity and Reliability Analysis
- Retinal and Macular Surgery
- Facial Trauma and Fracture Management
- Sulfur Compounds in Biology
- Multiple and Secondary Primary Cancers
- Advanced Wireless Communication Technologies
- Burn Injury Management and Outcomes
Shihezi University
2025
Shanghai Jiao Tong University
2013-2024
Inner Mongolia Agricultural University
2022-2024
Capital Medical University
2012-2024
Baoding People's Hospital
2024
Beijing Children’s Hospital
2024
Shanghai Clinical Research Center
2024
XinHua Hospital
2024
Shandong Provincial Hospital
2024
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2024
Evidence indicates that after brain injury, neurogenesis is enhanced in regions such as hippocampus, striatum, and cortex. To study the role of hypoxia-inducible factor-1 (HIF‑1α) Wnt signaling cerebral ischemia/hypoxia-induced proliferation neural stem cells (NSCs), we investigated NSCs, expression HIF‑1α, activation under conditions pathologic hypoxia vitro. NSCs were isolated from 30-day-old Sprague-Dawley rats subjected to 0.3% oxygen a microaerophilic incubation system. Cell was...
Efficient allocation and utilization of water resources are critical for the sustainable development agriculture in arid regions, particularly those heavily reliant on irrigation. Xinjiang, one China’s major agricultural faces significant challenges managing due to its climate dependence This study investigates spatial–temporal dynamics crop footprint (CWF) driving factors Xinjiang. Unlike previous studies Xinjiang that primarily focus total footprint, this research emphasizes blue (CWFB)...
Thymic atrophy has been described as a consequence of infection by several pathogens including highly pathogenic avian influenza virus and is induced through diverse mechanisms. However, whether A(H1N1)pdm09 induces thymic the mechanisms underlying this process have not completely elucidated. Our results show that severe led to progressive CD4+CD8+ double-positive (DP) T-cells depletion due apoptosis. The viruses were present in thymus, where they activated innate CD8+CD44hi single-positive...
Neuroprotection is a major therapeutic approach for ischemic brain injury. We investigated the neuroprotective effects induced by transplantation of human embryonic neural stem cells (NSCs) into cortical penumbra 24 h after focal cerebral ischemia.NSCs were prepared from brains obtained at 8 weeks gestation. Focal ischemia was in adult rats permanent occlusion middle artery. Animals randomly divided two groups: NSCs-grafted group and medium-grafted (control). Infarct size assessed 28 days...
OBJECTIVE: This prospective, randomized study compared the effectiveness of cable pin system (CPS) versus tension band wiring (TBW) for olecranon fracture fixation. METHODS: Patients with acute transverse or slight oblique fractures were randomly divided into two groups: one fixed by CPS and other TBW. Clinical outcome data collected analysed following a mean duration 21 months. RESULTS: The ± SD healing time was significantly shorter in group ( n = 30; 9.73 2.02 weeks) TBW 32; 11.13 2.21...
Summary In the pathological process of acute kidney injury (AKI), innate immune receptors are essential in inflammatory response modulation; however, precise molecular mechanisms still unclear. Our study sought to demonstrate renal tubular epithelial cells via Toll-like receptor-4 (TLR-4) and dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin 1 (DC-SIGN) signalling. We found that DC-SIGN exhibited strong expression human tissues. protein was increased...
Hypoxic culture potentiates mesenchymal stem cells (MSCs) to survive and secrete various growth factors. Genetically modified overexpressing bone morphogenic protein-2 (BMP-2) demonstrate strong osteogenic ability. Hence, we investigated the coeffect of hypoxic conditions BMP-2 overexpression on ability rabbit adipose-derived (rASCs) in vitro.Rabbit with or without adenoviral-BMP-2 transduction were cultured (1%) normoxic (21%) conditions. Cell viability, attachment, proliferation compared....
Abstract Objective This study aimed to investigate the benefit of Bonebridge devices in patients with single-sided deafness. Method Five deafness who were implanted recruited a single-centre study. Participants’ speech perception and horizontal sound localisation abilities assessed at 6 12 months post-operatively. Speech intelligibility noisy environments was measured three different testing conditions (speech noise presented from front, front contralateral (normal ear) side separately,...
Primary hepatocytes are widely used as a tool for studying metabolic function and regulation in the liver. However, properties of primary gradually lost after isolation. Here, we illustrated that fatty acid metabolism is major compromised process isolated hepatocytes, along with drastically decreased GSH ROS content, while lipid peroxidation increased. Gain- loss-of-function studies revealed Slc7a11 expression critical maintaining facilitating hormone-induced events, which synergistic...
<h3>Background:</h3> Vunakizumab (SHR-1314) is a novel humanized monoclonal IgG1/k antibody targeting IL-17A that has previously demonstrated robust efficacy and tolerability in treating plaque psoriasis. <h3>Objectives:</h3> Given the involvement of IL-17 pathway overlap symptoms psoriasis ankylosing spondylitis (AS), we conducted phase 2/3 trial to evaluate safety vunakizumab AS. <h3>Methods:</h3> This randomized, double-blind, adaptive, seamless, study (NCT04840485). Eligible patients had...
Dysbiosis of the gut-liver axis increases risk bacterial and metabolite influx into liver, which may contribute to development hepatocellular carcinoma (HCC). In this study, we compared microbiomes in HCC tumors adjacent tissues. We examined tissues from 19 patients diagnosed with HCC. find that liver capsule invasion presented higher alpha diversity at genus level than those without. The compositions stage II differed I Advanced, respectively. Metagenomic profiling revealed order...
Retinoid signaling disorders cause craniofacial deformity, among which infants with maternal vitamin A deficiency (VAD) exhibited malformation of the eye, nose, palate, and parietal jaw bone. Previous research uncovered pathogenesis eye defect cleft palate VAD in mice, but studies on skeletal deformity met obstacles, cell/lineage underlying mechanism remain unclear. The retinoic acid receptor (RAR) is key transcription factor retinoid signaling, individual knockout cannot simulate pathway...
The Paracheirodon axelrodi is an important freshwater fish in the Amazon basin of South America, more expensive than innesi. Here, we describe complete 17,100 base pair (bp) mitochondrial genome mohavensis. mitogenome has a nucleotide composition A (29.62%), T (29.41%), G (15.39%), and C (25.62%), encodes 13 protein subunits, 22 tRNAs, 12S rRNA 952 bp 16S 1665 bp, 1433 D-loop control region, each located conserved mtDNA structure typical for Characidae fishes. All protein-coding genes have...
This study investigated the audiometric and sound localisation results in patients with conductive hearing loss after bilateral Bonebridge implantation.Eight congenital microtia atresia supplied devices were enrolled this study. Hearing tests tested under unaided, unilateral aided conditions.Mean functional gain was higher a fitting than fitting, especially at 1.0-4.0 kHz (p < 0.05, both). The improvement speech reception threshold noise 2.3 dB signal-to-noise ratio compared 0.05). Bilateral...
Temperature is a crucial environmental factor that affects embryonic development, particularly for marine organisms with long development periods. However, the sensitive period of and role autophagy/apoptosis in temperature regulation cephalopods, enigmatic creatures, remain unclear. In this study, we cultured embryos Sepiella japonica, typical species local area East China Sea, at different incubation temperatures (18 ℃, 23 28 ℃) to investigate various developmental aspects, including...
Temperature is a crucial environmental factor that affects embryonic development, particularly for marine organisms with long development periods. However, the sensitive period of and role autophagy/apoptosis in temperature regulation cephalopods remain unclear. In this study, we cultured embryos Sepiella japonica, typical species local area East China Sea, at different incubation temperatures (18 °C, 23 28 °C) to investigate various developmental aspects, including morphological...
Objective: To investigate the effects of hypoxia-pretreated rat adipose-derived mesenchymal stem cells (ADSCs) conditioned medium on wound healing rats with full-thickness defects. Methods: (1) A 6-week-old male Sprague-Dawley was sacrificed by cervical dislocation, bilateral inguinal adipose tissue collected, third generation ADSCs were isolated collagenase digestion method, and morphology observed. The harvested divided into adipogenic induction group osteogenic according to random number...
Severe burns trigger the stress response, cause different degrees of damage to body, and participate in occurrence development immune dysfunction hypermetabolism after burn. Rational application analgesic sedative drugs is major method inhibiting severe burn-induced which can alleviate organ damages reduce incidence burn sepsis. Furthermore, integrated approaches including wound management, infection control, nutritional support, gastrointestinal tract protection, as well sleep etc.,...
Inner Mongolia cashmere goat is an excellent livestock breed formed through long-term natural selection and artificial breeding, currently a world-class dual-purpose producing meat. Multi trait animal model considered to significantly improve the accuracy of genetic evaluation in poultry, enabling indirect between traits. In this study, pedigree, genotype, environment, phenotypic records early growth traits goats were used build multi model., Then three methods including ABLUP, GBLUP,...
To explore the efficacy of venetoclax-based induction regimen for children with newly diagnosed acute myeloid leukemia (AML).
Abstract To compare clinical characteristics and survival outcomes of patients with multiple renal cell carcinoma versus single carcinoma. Develop a prognostic model for predicting prognosis in tumors analyze factors. Patients primary were selected from the Surveillance, Epidemiology, End Results database (2004–2015). They divided into single-tumor multiple-tumor groups. Survival analysis was conducted using Kaplan–Meier method log-rank test. A Cox regression used to identify potential total...
In order to determine the design characteristics of propeller polar navigation ships and improve its operation reliability, this paper analyzes typical damage forms based on inspection results wharf, requirements in ice area, area.