A5100650442- Hair Growth and Disorders
- Genetic and phenotypic traits in livestock
- Cancer-related molecular mechanisms research
- Genetic Mapping and Diversity in Plants and Animals
- Skin and Cellular Biology Research
- Genetic diversity and population structure
- Rangeland Management and Livestock Ecology
- Wnt/β-catenin signaling in development and cancer
- RNA Research and Splicing
- Genomics and Phylogenetic Studies
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Reproductive Biology and Fertility
- Reproductive Physiology in Livestock
- Animal Genetics and Reproduction
- Sperm and Testicular Function
- Plant Disease Resistance and Genetics
- RNA regulation and disease
- Effects of Environmental Stressors on Livestock
- Silk-based biomaterials and applications
- Cancer and Skin Lesions
- melanin and skin pigmentation
- Dyeing and Modifying Textile Fibers
- Rice Cultivation and Yield Improvement
- Historical Gender and Feminism Studies
Inner Mongolia Agricultural University
2016-2025
Ministry of Agriculture and Rural Affairs
2020-2024
Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine
2019-2024
Shenzhen University
2024
Nanjing Medical University
2023-2024
Huazhong Agricultural University
2024
Jiangsu Province Hospital
2023-2024
Hubei Academy of Agricultural Sciences
2023
Hebei Normal University of Science and Technology
2023
Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences
2014-2022
An instrument for whole-genome optical mapping is used to assemble the genome of domestic goat into super-long scaffolds. We report ∼2.66-Gb sequence a female Yunnan black goat. The was obtained by combining short-read sequencing data and from high-throughput instrument. facilitated assembly super-scaffolds >5× longer N50 metric than scaffolds augmented fosmid end (scaffold = 3.06 Mb, super-scaffold 16.3 Mb). Super-scaffolds are anchored on chromosomes based conserved synteny with cattle,...
Global climate change has a significant effect on extreme environments and profound influence species survival. However, little is known of the genome-wide pattern livestock adaptations to over short time frame following domestication. Sheep (Ovis aries) have become well adapted diverse range agroecological zones, including certain (e.g., plateaus deserts), during their post-domestication (approximately 8–9 kya) migration differentiation. Here, we generated whole-genome sequences from 77...
Despite much attention, history of sheep (Ovis aries) evolution, including its dating, demographic trajectory and geographic spread, remains controversial. To address these questions, we generated 45 complete 875 partial mitogenomic sequences, performed a meta-analysis published ovine mitochondrial DNA sequences (n = 3,229) across Eurasia. We inferred that O. orientalis musimon share the most recent female ancestor with aries at approximately 0.790 Ma (95% CI: 0.637–0.934 Ma) during Middle...
Tibetan sheep are the most common and widespread domesticated animals on Qinghai–Tibetan Plateau (QTP) have played an essential role in permanent human occupation of this high-altitude region. However, precise timing, route, process pastoralism QTP region remain poorly established, little is known about underlying genomic changes that occurred during process. Here, we investigate variation using whole-genome sequences, single nucleotide polymorphism arrays, mitochondrial DNA, Y-chromosomal...
China has a rich resource of native sheep (Ovis aries) breeds associated with historical movements several nomadic societies. However, the history and societies in ancient remains poorly understood. Here, we studied genomic diversity Chinese using genome-wide SNPs, mitochondrial Y-chromosomal variations > 1,000 modern samples. Population analyses combined archeological records ethnic demographics data revealed genetic signatures origins, secondary expansions admixtures, thereby revealing...
Domestic sheep and their wild relatives harbor substantial genetic variants that can form the backbone of molecular breeding, but genome landscapes remain understudied. Here, we present a comprehensive resource for ovine species, landraces improved breeds domestic sheep, comprising high-coverage (∼16.10×) whole genomes 810 samples from 7 species 158 diverse populations. We detected, in total, ∼121.2 million single nucleotide polymorphisms, ∼61 which are novel. Some display significant (P <...
The domestication and subsequent global dispersal of livestock are crucial events in human history, but the migratory episodes during history remain poorly documented [1-3]. Here, we first developed a set 493 novel ovine SNPs male-specific region Y chromosome (MSY) by genome mapping. We then conducted comprehensive genomic analysis chromosome, mitochondrial DNA, whole-genome sequence variations large number 595 rams representing 118 domestic populations across world. detected four different...
MicroRNAs (miRNAs) are a class of small RNAs that play significant roles in regulating the expression post-transcriptional skin and hair follicle gene. In recent years, extensive studies on these microRNAs have been carried out mammals such as mice, rats, pigs cattle. By comparison, number identified goats is relatively low; particular, miRNAs associated with processes development remain largely unknown. this study, areas where cashmere grows anagen were sampled. A total 10,943,292 reads...
Inner Mongolia and Liaoning cashmere goats are two outstanding Chinese multipurpose breeds that adapt well to the semi-arid temperate grassland. These characterized by their soft fibers, thus making them great models identify genomic regions associated with fiber traits. Whole-genome sequencing of 70 produced more than 5.52 million single-nucleotide polymorphisms 710,600 short insertions deletions. Further analysis these genetic variants showed some population-specific molecular markers for...
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12864-024-10249-7.
Renowned for its invaluable undercoat, the cashmere goat is well known. The growth of fibre initiates when relatively inactive telogen stage transitions to anagen stage, which involves active proliferation. However, molecular mechanisms responsible this process are still unclear. Here, SWATH mass spectrometry (MS), a comparative proteomic analysis, was conducted examine alterations in Inner Mongolia skin samples at two different developmental stages (anagen and telogen). In total, 2414...
Hollow MoS<sub>2</sub> nanospheres with enhanced energy storage performance has been synthesized from core–shell ZnS@MoS<sub>2</sub> nanostructures.
It is broadly expected that next generation sequencing will ultimately generate a complete genome as the latest goat reference (ARS1), which considered to be one of most continuous assemblies in livestock. However, rich diversity worldwide breeds indicates from individual would insufficient represent whole genomic contents goats. By comparing nine de novo seven sibling species domestic with ARS1 and using resequencing transcriptome data goats for verification, we identified total 38.3 Mb...
Abstract Inner Mongolia cashmere goats, as an important part of animal husbandry production, play role in fiber industry. In recent years, scientific research has made a lot explorations on the molecular regulation mechanism hair follicle cycle growth, but few studies have been reported development fetal period. This study was based completion 21 skin samples mRNA and miRNA sequencing 7 periods (45 days, 55 days,65 days,75 days,95 days,115 days 135 days) Cashmere goat. The target genes...
Abstract Background Cashmere goat is famous for its high-quality fibers. The growth of cashmere in secondary hair follicles exhibits a seasonal pattern arising from circannual changes the natural photoperiod. Although several studies have compared and analyzed differences gene expression between different follicle stages, selection samples these relies on research experience or morphological evidence. Distinguishing cycle according to patterns may help explore regulation mechanisms related...
Cashmere goat from Inner Mongolia is an excellent local breed in China, and the related cashmere product a kind of precious textile raw material with high price. generated secondary hair follicles, which has obvious annual periodicity includes three different stages: anagen, catagen, telogen. Therefore, we investigated skin transcriptome data for 12 months using weighted gene co-expression network analysis (WGCNA) to explore essential modules, pathways, genes responsible periodic growth...
Mitochondria play a crucial role in energy metabolism through oxidative phosphorylation.Organisms living at high altitudes are potentially influenced by oxygen deficits and cold temperatures.The severe environmental conditions can impact on direct selection of mitochondrial DNA.As wide-ranging animal, the domestic horse (Equus caballus) has developed various morphological physiological characteristics for adapting to different altitudes.Thus, this is good species studying adaption molecular...
There are two main types of hair follicle in Inner Mongolia Cashmere goats, the primary (PHF) producing fibers and secondary (SHF) cashmere fibers. Of both from cashmere-bearing goats Aerbasi, Mongolia, timing cyclical phases for have been well clarified but less noticeable. Herein, we evaluated transcriptome PHF SHF same three Aerbasi at catagen- telogen phase growth. We totally found 1977 DEGs between PHFs catagen SHF, 1199 telogen- 2629 755 SHF. By analyzing gene functions based on GO...
Abstract Crossovers generated by homologous recombination ensure proper chromosome segregation during meiosis. Crossover interference results in chiasmata being more evenly distributed along chromosomes, but the mechanism underlying crossover remains elusive. Based on large pedigrees of Holstein and Jersey cattle with genotype data, we extracted three-generation families, including 147,327 male 71,687 female meioses Holstein, 108,163 37,008 Jersey, respectively. We identified crossovers...
Inner Mongolian Cashmere goat is an excellent local breed selected for the dual-purpose of cashmere and meat. There are three lines goat: Erlangshan, Alashan Aerbasi. a kind precious textile raw material with high price. derived from secondary hair follicle (SHF), while primary (PHF). The growth cycle SHF 1 year, it can be divided into different stages: anagen, catagen telogen. In this study, we tried to find some important influence factors in skin tissue goats by RNA sequencing (RNA-Seq)....
Objective: Body weight is an important economic trait for a goat, which greatly affects animal growth and survival. The purpose of this study was to identify genes associated with birth (BW), weaning (WW), yearling (YW). Materials Methods: In study, genome-wide association (GWAS) BW, WW, YW determined using the GGP_Goat_70K single-nucleotide polymorphism (SNP) chip in 1,920 Inner Mongolia cashmere goats. Results: We discovered that 21 SNPs were significantly BW on levels. These located 10...