A5100353852- Genetic and phenotypic traits in livestock
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Renal and related cancers
- Pluripotent Stem Cells Research
- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Phylogenetic Studies
- Animal Genetics and Reproduction
- Lipid metabolism and biosynthesis
- Single-cell and spatial transcriptomics
- Rangeland Management and Livestock Ecology
- Genetic diversity and population structure
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- Cleft Lip and Palate Research
- Gene Regulatory Network Analysis
- Chromosomal and Genetic Variations
- Chromatin Remodeling and Cancer
- Genetic and Kidney Cyst Diseases
- Cell Image Analysis Techniques
- Genomic variations and chromosomal abnormalities
- Congenital heart defects research
- RNA modifications and cancer
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Fatty Acid Research and Health
University of Chinese Academy of Sciences
2020-2025
Liaocheng University
2025
Shanghai Institute of Nutrition and Health
2025
Guilin Medical University
2024
Chinese Academy of Sciences
2013-2024
Institute of Zoology
2013-2024
Tianjin Chest Hospital
2024
Alibaba Group (China)
2024
Dalian Ocean University
2023
Huazhong Agricultural University
2023
Abstract Understanding the genetic changes underlying phenotypic variation in sheep ( Ovis aries ) may facilitate our efforts towards further improvement. Here, we report deep resequencing of 248 including wild ancestor O. orientalis ), landraces, and improved breeds. We explored variome selection signatures. detected genomic regions harboring genes associated with distinct morphological agronomic traits, which be past potential future targets domestication, breeding, selection. Furthermore,...
During mammalian preimplantation embryo development, when the first asymmetry emerges and how it develops to direct distinct cell fates remain longstanding questions. Here, by analyzing single-blastomere transcriptome data from mouse human pre-implantation embryos, we revealed that initial blastomere-to-blastomere biases emerge as early embryonic cleavage division, following a binominal distribution pattern. The zygotic transcriptional activation further elevated overall during 2- 16-cell...
The domestication and subsequent global dispersal of livestock are crucial events in human history, but the migratory episodes during history remain poorly documented [1-3]. Here, we first developed a set 493 novel ovine SNPs male-specific region Y chromosome (MSY) by genome mapping. We then conducted comprehensive genomic analysis chromosome, mitochondrial DNA, whole-genome sequence variations large number 595 rams representing 118 domestic populations across world. detected four different...
Abstract The domestication and subsequent development of sheep are crucial events in the history human civilization agricultural revolution. However, impact interspecific introgression on genomic regions under selection remains unclear. Here, we analyze whole genomes domestic their wild relative species. We found from such as snow its American relatives (bighorn thinhorn sheep) into urial, Asiatic European mouflons. observed independent adaptive mouflons, well shared introgressed both argali...
The fat tail of sheep is an important organ that has evolved to adapt extreme environments. However, the genetic mechanisms underlying phenotype remain poorly understood. Here, we characterize transcriptome and lipidome profiles morphological changes in 250 adipose tissues from two thin-tailed three fat-tailed populations summer winter. We implement whole-genome selective sweep tests identify variants related fat-tails. a set functional genes show differential expression These are...
Understanding the genetic mechanisms of phenotypic variation in hybrids between domestic animals and their wild relatives may aid germplasm innovation. Here, we report high-quality genome assemblies a male Pamir argali ( O . ammon polii , 2 n = 56), female Tibetan sheep aries 54), hybrid sheep, high-throughput sequencing 425 ovine animals, including sheep. We detected genomic synteny Chromosome two acrocentric chromosomes argali. revealed consistent satellite repeats around chromosome...
Craniofacial microsomia (CFM) is a rare congenital anomaly that involves immature derivatives from the first and second pharyngeal arches. The genetic pathogenesis of CFM still unclear. Here we interrogate 0.9 million variants in 939 cases 2,012 controls China. After genotyping an additional 443 1,669 controls, identify 8 significantly associated loci with most significant SNP rs13089920 (logistic regression P=2.15 × 10(-120)) 5 suggestive loci. above 13 loci, harboured by candidates ROBO1,...
Large language models (LLMs) have made breakthroughs in natural processing (NLP) and understanding, brought revolutions many other fields [1-4]. Inspired by those successes, several large cellular (LCMs) adopting similar structures of LLMs been developed for single-cell transcriptomics, including (but not limited to) scBERT [5], Geneformer [6], scGPT [7], scFoundation [8], GeneCompass [9]. The practices these shown LCMs' power potential various biological tasks illustrated the possibilities...
Tail fat is important for fat-tailed or fat-rumped sheep to survive in harsh environments. However, the molecular mechanism underlying tail deposition remains unclear. In this study, we comprehensively characterized transcriptome, untargeted lipidome, and targeted metabolome profiles of adipose tissues from Large-tailed Han (long sheep) Hu (short sheep). We identified 183 differentially expressed genes (DEGs), 55 differential lipids (DLs) 17 metabolites (DMs) tails sheep. Among DEGs selected...
Claustrum orchestrates brain functions via its connections with numerous regions, but molecular and cellular organization remains unresolved. Single-nucleus RNA sequencing of 227,750 macaque claustral cells identified 48 transcriptome-defined cell types, most glutamatergic neurons similar to deep-layer insular neurons. Comparison macaque, marmoset, mouse transcriptomes revealed macaque-specific types. Retrograde tracer injections at 67 cortical 7 subcortical regions defined four distinct...
Abstract Prolific breeds of domestic sheep ( Ovis aries ) are important genetic resources due to their reproductive performance, which is characterized by multiple lambs per birth and out-of-season breeding. However, the lack a comprehensive understanding mechanisms underlying traits, particularly from evolutionary genomics perspective, has impeded efficient advancement Here, for first time, performing RNA-sequencing we built de novo transcriptome assembly ovarian endometrial tissues in...
Genomic prediction, which is based on solving linear mixed-model (LMM) equations, the most popular method for predicting breeding values or phenotypic performance economic traits in livestock. With need to further improve of genomic nonlinear methods have been considered as an alternative and promising approach. The excellent ability predict phenotypes animal husbandry has demonstrated by machine learning (ML) approaches, rapidly developed. To investigate feasibility reliability implementing...
Copy number variations (CNVs) are a major source of structural variation in mammalian genomes. Here, we characterized the genome-wide CNV 2059 sheep from 67 populations all over world using Ovine Infinium HD (600K) SNP BeadChip. We tested their associations with distinct phenotypic traits by conducting multiple independent tests. In total, detected 7547 unique CNVs and 18,152 events 1217 non-redundant regions (CNVRs), covering 245 Mb (∼10%) whole genome. identified seven CNVRs frequencies...
The complete mitochondrial genome of Formica selysi has been assembled from Illumina sequencing data with an average coverage 2733X. circular was 16,752 bp in length, and consists 13 protein-coding genes (PCGs), 22 transfer RNAs (tRNAs), two ribosomal (rRNAs) one D-loop region. All PCGs initiated ATN codons terminated the TAA codon. nucleotide composition highly asymmetric (40.33% A, 11.07% C, 5.66% G 42.94% T) overall GC content 16.73%. Unlike those most other insects, F. characterized by...
Significance Tetraploid complementation, through which an entire organism is produced from pluripotent donor cells, taken as the most stringent test for pluripotency. However, it remains unclear whether embryonic stem cells (ESCs) of other species besides mice can pass this test. Our results demonstrated capacity rat ESCs to produce live rats via tetraploid complementation and how lost during in vitro culture. This report demonstrates that We believe original work will facilitate...
DATA REPORT article Front. Genet., 17 August 2021 | https://doi.org/10.3389/fgene.2021.714852
Enhancing pig reproductive efficiency has the potential to have a significant positive economic impact on business. We collected four reproduction records of 734 Yunong black pigs in this study, including total number piglets born (TNB), alive (NBA), average birth interval (ABI) and weight (ABW). A 453 were genotyped with Porcine 50K SNP BeadChip. Twenty-five SNPs 35 genomic areas found substantial performance by single-locus GWAS single-step (ssGWAS). For ssGWAS, we that two regions...
As a new freshwater aquaculture product, triploid loaches (Misgurnus anguillicaudatus) are characterized by fast growth, high-quality meat, high edibility, resistance to disease, and sterility. In this study, natural tetraploid loach (4n = 100) (♀) was crossed with diploid (2n 50) (♂), thus creating the hybrid (3n 75). The histological observations of offspring controls at 4 days post-hatching (dph), 15dph, 22dph, 50dph showed that most were abortive in early gonad differentiation process....
The vascular system and the neural processes occur simultaneously, interaction among them is fundamental to normal development of central nervous system. Arid1a (AT-rich domain 1A), which encodes an epigenetic subunit SWI/SNF chromatin-remodelling complex, associated with promoter-mediated gene regulation histone modification. However, molecular mechanism between cerebrovascular progenitor cells (NPCs) remains unclear. To generate Arid1acKO-Tie2 mice, Arid1afl/fl mice were hybridized...
Abstract Whole‐genome sequencing has advanced the study of species evolution, including detection genealogical discordant events such as ancient hybridization and incomplete lineage sorting (ILS). The evolutionary history bighorn ( Ovis canadensis ) thinhorn dalli sheep present an ideal system to investigate discordance due their recent rapid radiation putative secondary contact between subspecies, specifically dark pelage Stone O . stonei predominately white Dall ), during last ice age....