A5090862572- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Memory and Neural Mechanisms
- Genetic Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Single-cell and spatial transcriptomics
- Amyotrophic Lateral Sclerosis Research
- Epigenetics and DNA Methylation
- Neuroscience and Neural Engineering
- Parkinson's Disease Mechanisms and Treatments
BGI Group (China)
2025
University of Tübingen
2020-2023
Senckenberg Centre for Human Evolution and Palaeoenvironment
2021-2022
Bernstein Center for Computational Neuroscience Tübingen
2020-2022
Institute of Neurobiology
2021-2022
BGI Research
2022
Universität Ulm
2018
Information processing in neuronal networks involves the recruitment of selected neurons into coordinated spatiotemporal activity patterns. This sparse activation results from widespread synaptic inhibition conjunction with neuron-specific excitation. We report selective hippocampal pyramidal cells patterned network activity. During ripple oscillations awake mice, spiking is much more likely which axon originates a basal dendrite rather than soma. High-resolution recordings vitro and...
Neural circuits are made of a vast diversity neuronal cell types. While immense progress has been in classifying neurons based on morphological, molecular, and functional properties, understanding how this heterogeneity contributes to brain function during natural behavior remained largely unresolved. In the present study, we combined juxtacellular recording labeling technique with optogenetics freely moving mice. This allowed us selectively target molecularly defined classes for vivo...
Claustrum orchestrates brain functions via its connections with numerous regions, but molecular and cellular organization remains unresolved. Single-nucleus RNA sequencing of 227,750 macaque claustral cells identified 48 transcriptome-defined cell types, most glutamatergic neurons similar to deep-layer insular neurons. Comparison macaque, marmoset, mouse transcriptomes revealed macaque-specific types. Retrograde tracer injections at 67 cortical 7 subcortical regions defined four distinct...
Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of motoneurons in primary motor cortex (pMO) and spinal cord. However, pathogenic process involves multiple subnetworks brain functional MRI studies demonstrate an increase connectivity areas connected to pMO despite ongoing neurodegeneration. The extent structural basis subnetwork remodeling experimentally tractable models remain unclear. We have developed a new retrograde AAV9 quantitatively map...
Plasticity within hippocampal circuits is essential for memory functions. The CA2/CA3 region thought to be able rapidly store incoming information by plastic modifications of synaptic weights its recurrent network. High-frequency spike-bursts are believed this process, serving as triggers plasticity. Given the diversity pyramidal neurons, it currently unknown whether and how burst activity, assessed <i>in vivo</i> during natural behavior, relates principal cell heterogeneity. To explore...
Abstract Background The basal ganglia are a complex of interconnected subcortical structures located beneath the mammalian cerebral cortex. degeneration dopaminergic neurons in is primary pathological feature Parkinson's disease. Due to lack integrated analysis multiomics datasets across multiple brain regions, very little known about regulatory mechanisms this area. Findings We utilized high-throughput transcriptomic and epigenomic profile over 270,000 single-nucleus cells create cellular...