A5068371697- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Erythrocyte Function and Pathophysiology
- Neural dynamics and brain function
- Axon Guidance and Neuronal Signaling
- Photoreceptor and optogenetics research
- RNA Research and Splicing
- Caveolin-1 and cellular processes
- Neuroscience and Neural Engineering
- Lipid Membrane Structure and Behavior
- Phagocytosis and Immune Regulation
- Cell death mechanisms and regulation
- Mitochondrial Function and Pathology
Heidelberg University
2020-2025
University Hospital Heidelberg
2021-2025
Bernstein Center for Computational Neuroscience Heidelberg-Mannheim
2021-2023
Medizinische Fakultät Mannheim
2021-2022
University Medical Centre Mannheim
2022
Heidelberg University
2022
Abstract The axon initial segment (AIS) is a critical microdomain for action potential initiation and implicated in the regulation of neuronal excitability during activity-dependent plasticity. While structural AIS plasticity has been suggested to fine-tune activity when network states change, whether it acts vivo as homeostatic regulatory mechanism behaviorally relevant contexts remains poorly understood. Using mouse whisker-to-barrel pathway model system combination with...
Information processing in neuronal networks involves the recruitment of selected neurons into coordinated spatiotemporal activity patterns. This sparse activation results from widespread synaptic inhibition conjunction with neuron-specific excitation. We report selective hippocampal pyramidal cells patterned network activity. During ripple oscillations awake mice, spiking is much more likely which axon originates a basal dendrite rather than soma. High-resolution recordings vitro and...
The canonical view of neuronal function is that inputs are received by dendrites and somata, become integrated in the somatodendritic compartment upon reaching a sufficient threshold, generate axonal output with axons emerging from cell body. latter not necessarily case. Instead, may originate dendrites. terms ‘axon carrying dendrite’ (AcD) ‘AcD neurons’ have been coined to describe this feature. In rodent hippocampus, AcD cells shown be functionally ‘privileged’, since here can circumvent...
The axon initial segment (AIS) constitutes not only the site of action potential initiation, but also a hub for activity-dependent modulation output generation. Recent studies shedding light on AIS function used predominantly post-hoc approaches since no robust murine in vivo live reporters exist. Here, we introduce reporter line which is intrinsically labeled by an ankyrin-G-GFP fusion protein activated Cre recombinase, tagging native Ank3 gene. Using confocal, superresolution, and...
Abstract The axon initial segment (AIS) constitutes not only the site of action potential initiation, but also a hub for activity-dependent modulation output generation. Recent studies shedding light on AIS function used predominantly post-hoc approaches since no robust murine in vivo live reporters exist. Here, we introduce reporter line which is intrinsically labeled by an ankyrin-G-GFP fusion protein activated Cre recombinase, tagging native Ank3 gene. Using confocal, superresolution, and...
Abstract In humans, most neurons are born during embryonic development and have to persist throughout the entire lifespan of an individual. Thus, human develop elaborate survival strategies protect against accidental cell death. We set out decipher developmental adaptations resulting in neuronal resilience. demonstrate that, time course maturation, install a complex complementary anti-apoptotic signaling network. This includes i.) downregulation central proteins intrinsic apoptosis pathway...
Abstract The rodent hippocampus expresses a variety of neuronal network oscillations depending on the behavioral state animal. Locomotion and active exploration are accompanied by theta‐nested gamma while resting states slow‐wave sleep dominated intermittent sharp wave‐ripple complexes. It is believed that rhythms create framework for efficient acquisition information whereas wave‐ripples thought to be involved in consolidation retrieval memory. While not strictly mutually exclusive, one two...
The axon initial segment (AIS) constitutes not only the site of action potential initiation, but also a hub for activity-dependent modulation output generation. Recent studies shedding light on AIS function used predominantly post-hoc approaches since no robust murine in vivo live reporters exist. Here, we introduce reporter line which is intrinsically labeled by an ankyrin-G-GFP fusion protein activated Cre recombinase, tagging native Ank3 gene. Using confocal, superresolution, and...
Summary In certain subtypes of pyramidal neurons, axons originate from basal dendrites, resulting in an axon-carrying dendrite branch with unique functional characteristics (AcD cells). The number AcD cells increases during development, however, it is so far unclear whether neurons remodel their axon emergence throughout lifetime response to changes network activity. To test our hypothesis such large-scale morphological plasticity, we utilized vitro and vivo strategies mouse primary...
The axon initial segment (AIS) constitutes not only the site of action potential initiation, but also a hub for activity-dependent modulation output generation. Recent studies shedding light on AIS function used predominantly post hoc approaches since no robust murine in vivo live reporters exist. Here, we introduce reporter line which is intrinsically labeled by an ankyrin-G-GFP fusion protein activated Cre recombinase, tagging native Ank3 gene. Using confocal, superresolution, and...
The axon initial segment (AIS) constitutes not only the site of action potential initiation, but also a hub for activity-dependent modulation output generation. Recent studies shedding light on AIS function used predominantly post-hoc approaches since no robust murine in vivo live reporters exist. Here, we introduce reporter line which is intrinsically labeled by an ankyrin-G-GFP fusion protein activated Cre recombinase, tagging native Ank3 gene. Using confocal, superresolution, and...
Abstract The canonical view of neuronal function is that inputs are received by dendrites and somata, become integrated in the somatodendritic compartment upon reaching a sufficient threshold, generate axonal output with axons emerging from cell body. latter not necessarily case. Instead, may originate dendrites. terms “axon carrying dendrite” (AcD) “AcD neurons” have been coined to describe this feature. Here, we report on diversity axon origins neocortical pyramidal cells. We found...