A5056085229- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Neuroinflammation and Neurodegeneration Mechanisms
Heidelberg University
2021
Heidelberg University
2020-2021
Abstract The rodent hippocampus expresses a variety of neuronal network oscillations depending on the behavioral state animal. Locomotion and active exploration are accompanied by theta‐nested gamma while resting states slow‐wave sleep dominated intermittent sharp wave‐ripple complexes. It is believed that rhythms create framework for efficient acquisition information whereas wave‐ripples thought to be involved in consolidation retrieval memory. While not strictly mutually exclusive, one two...
Abstract Neurons are highly vulnerable to conditions of hypoxia-ischemia (HI) such as stroke or transient ischemic attacks. Recovery cognitive and behavioral functions requires re-emergence coordinated network activity, which, in turn, relies on the well-orchestrated interaction pyramidal cells (PYRs) interneurons. We therefore modelled HI mouse hippocampus, a particularly region showing marked loss PYR fast-spiking interneurons (FSIs) after hypoxic-ischemic insults. Transient oxygen-glucose...