A5100460418- Lymphoma Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Protein Degradation and Inhibitors
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Streptococcal Infections and Treatments
- Inflammasome and immune disorders
- CAR-T cell therapy research
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Single-cell and spatial transcriptomics
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Neural dynamics and brain function
- Phagocytosis and Immune Regulation
- NF-κB Signaling Pathways
- Chronic Myeloid Leukemia Treatments
- Glycosylation and Glycoproteins Research
- Nanoplatforms for cancer theranostics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuroblastoma Research and Treatments
- Phytochemicals and Antioxidant Activities
Columbia University Irving Medical Center
2016-2025
Stanford University
2021-2025
City University of Hong Kong
2024-2025
University of Chinese Academy of Sciences
2023-2025
Shanghai Institute of Nutrition and Health
2023-2025
Qiqihar University
2025
Shanxi Medical University
2025
Tianjin Medical University
2025
Xuzhou Medical College
2025
Zhejiang University
2024
Emergence of severe acute respiratory syndrome (SARS) from the winter 2002 to spring 2003 has caused a serious threat public health.To evaluate safety and immunogenicity inactivated SARS coronavirus (SARS-CoV) vaccine, 36 subjects received two doses 16 SARS-CoV units (SU) or 32 SU placebo control.On day 42, seroconversion reached 100% for both vaccine groups. On 56, participants in group receiving 91.1% had seroconverted. The geometric mean titre neutralizing antibody peaked 2 weeks after...
Abstract Purpose: Both gain-of-function enhancer of zeste homolog 2 (EZH2) mutations and inactivating histone acetyltransferases mutations, such as CREBBP EP300, have been implicated in the pathogenesis germinal center (GC)–derived lymphomas. We hypothesized that direct inhibition EZH2 deacetyltransferase (HDAC) would be synergistic GC-derived Experimental Design: Lymphoma cell lines (n = 21) were exposed to GSK126, an inhibitor, romidepsin, a pan-HDAC inhibitor. Synergy was assessed by...
The neutrophil-to-lymphocyte ratio (NLR), a simple marker of systemic inflammation, is crucial in the progression cardiovascular diseases (CVD). Its predictive value for all-cause and mortality CVD patients with diabetes or pre-diabetes remains unclear. We analyzed 3,780 from National Health Nutrition Examination Survey (2001-2018). Kaplan-Meier survival curves, weighted Cox proportional hazards models, restricted cubic spline (RCS) analyses were used to assess relationship between NLR risk....
Significance BCL2 selective inhibitors are promising agents currently under clinical investigation for treatment of BCL2-dependent cancers. However, the activity in patients with diffuse large B cell lymphoma (DLBCL) has been disappointing. In this study, we identified PMAIP1/NOXA gene amplification as a marker sensitivity to DLBCL. Cells lacking NOXA were less sensitive due codependency on MCL1 and proteins. We show that pharmacologic induction by HDAC inhibitor panobinostat primes DLBCL...
Neoadjuvant chemotherapy (NAC) has become the main treatment option for breast cancer. Its adverse drug reactions (ADRs) make NAC painful both physiologically and psychologically. The factor pathological complete remission (pCR) describes how well a series of six or more chemotherapeutic treatments works on patient. This study investigated possibility predicting pCR using only nodal sizes first three treatments. A best feature combination each cancer subtype was screened from real sizes`...
Acute pulmonary embolism represents the third most prevalent cardiovascular pathology, following coronary heart disease and hypertension. Its untreated mortality rate is as high 20–30%, which a significant threat to patient survival. In view of current lack real-time monitoring techniques for acute embolism, this study primarily investigates potential pulsatility electrical impedance tomography (EIT) technique detection through collection imaging pulsatile signal blood flow. A...
Efficient RNA production is essential for therapeutic applications. Currently, mRNA generated by in vitro transcription with polymerases at a constant temperature. The success of these transcriptions depends on various factors including sequence composition and size. Sometimes, especially long RNAs, achieving efficient transcript yields are challenging. We developed novel approach incorporating high-temperature denaturation step. Our protocol includes the following two steps thermal cycling...
Relapse continues to limit survival for patients with B-cell acute lymphoblastic leukemia (B-ALL). Previous studies have independently implicated activation of developmental signaling pathways and increased glucose consumption chemo-resistance relapse risk. Here, we connect these observations, demonstrating that B-ALL cells active signaling, defined by high expression phosphorylated ribosomal protein S6 ("pS6+ cells"), are metabolically unique dependent. Isotope tracing metabolic flux...
ABSTRACT We aim to establish the fingerprint profile of Er Miao San (EMS) that aims accurately evaluate quality EMS samples and identify markers for different batches explore its related targets pathways treatment rheumatoid arthritis. HPLC was employed with an Agilent C18 column. Cluster analysis principal component were conducted by using SPSS SIMCA software. Network pharmacology techniques utilized potential in The established, featuring a total 15 common peaks, among which nine...
Inactivating, monoallelic mutations in histone acetyltransferases (HATs) CREBBP/EP300 are common germinal center (GC) B-cell lymphomas and implicated derangements of the GC reaction, evasion immune surveillance, disease initiation. This study evaluates a first-in-class HAT activator, YF2, as way to allosterically induce functional allele. YF2 binds bromo/RING domains CREBBP/p300, increasing enzyme auto-acetylation activation, is selectively cytotoxic HAT-mutated lymphoma cell lines. induces...
Immunosuppression increases disease risk, and the natural compound polydatin (PD) has been reported to modulate immune-related disorders. In cyclophosphamide-induced immunosuppressed mice, PD was evaluated for its immunomodulatory effects. Immune organ indices were measured, while H&E staining ELISA assessed spleen pathology serum cytokine levels. The proliferation of splenic lymphocytes, both total subpopulation, determined using concanavalin A or lipopolysaccharide stimulation, with...
Claustrum orchestrates brain functions via its connections with numerous regions, but molecular and cellular organization remains unresolved. Single-nucleus RNA sequencing of 227,750 macaque claustral cells identified 48 transcriptome-defined cell types, most glutamatergic neurons similar to deep-layer insular neurons. Comparison macaque, marmoset, mouse transcriptomes revealed macaque-specific types. Retrograde tracer injections at 67 cortical 7 subcortical regions defined four distinct...