A5100393357- Pain Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Neurobiology and Insect Physiology Research
- Neuropeptides and Animal Physiology
- Dermatology and Skin Diseases
- Hydraulic Fracturing and Reservoir Analysis
- Circadian rhythm and melatonin
- Neuroinflammation and Neurodegeneration Mechanisms
- Sleep and related disorders
- Neuroscience and Neuropharmacology Research
- Mental Health Research Topics
- Ocular Surface and Contact Lens
- Child and Adolescent Psychosocial and Emotional Development
- Gastrointestinal motility and disorders
- Pharmacological Effects of Natural Compounds
- Asthma and respiratory diseases
- Sleep and Wakefulness Research
- Herbal Medicine Research Studies
- Seismic Imaging and Inversion Techniques
- Seismic Waves and Analysis
- Ion Channels and Receptors
- Olfactory and Sensory Function Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Attention Deficit Hyperactivity Disorder
- Cell Image Analysis Techniques
Guiyang College of Traditional Chinese Medicine
2025
Center for Excellence in Brain Science and Intelligence Technology
2018-2025
University of Chinese Academy of Sciences
2018-2025
Sichuan University
2024
Chinese Academy of Sciences
2012-2024
West China Hospital of Sichuan University
2024
Weatherford College
2024
Peking University
2023
Institute of Geology and Geophysics
2012
Proper timing of vigilance states serves fundamental brain functions. Although disturbance sleep onset rapid eye movement (SOREM) is frequently reported after orexin deficiency, their causal relationship still remains elusive. Here, we further study a specific subgroup neurons with convergent projection to the REM promoting sublaterodorsal tegmental nucleus (OX SLD neurons). Intriguingly, although OX and other projection-labeled exhibit similar activity dynamics during sleep, only activation...
Spinal gastrin-releasing peptide receptor-expressing (GRPR+) neurons play an essential role in itch signal processing. However, the circuit mechanisms underlying modulation of spinal GRPR+ by direct local and long-range inhibitory inputs remain elusive. Using viral tracing electrophysiological approaches, we dissected neural circuits control neurons. We found that galanin+ GABAergic form synapses with cord important gating neuron-dependent signaling pathway. also receive from expressing...
Mu-opioid receptors (MORs) are crucial for analgesia by both exogenous and endogenous opioids. However, the distinct mechanisms underlying these two types of opioid remain largely unknown. Here, we demonstrate that analgesic effects opioids on inflammatory pain mediated MORs expressed in subpopulations neurons mice. We found opioid-induced is Vglut2+ glutamatergic but not GABAergic neurons. In contrast, rather than Furthermore, at spinal level mainly involved effect morphine acute pain,...
This study explores the mechanism of action tanshinone IIA in treatment chronic obstructive pulmonary disease (COPD) using network pharmacology and molecular docking. The targets were searched by Swiss Target Prediction Database, PharmMapper SuperPred TargetNet Database. COPD obtained Genecards OMIM Therapeutic then intersection selected as COPD. intersecting imported into STRING database to obtain PPI top10 relevant targets, GO enrichment KEGG signaling pathway analysis performed R...
To explore the potential mechanism in Cuscuta sinensis on diarrhea-type irritable bowel syndrome using network pharmacology and molecular docking techniques. First, active components related targets of were found setting oral utilization >30% drug-like properties greater than or equal to 0.18 as filter information from TCMSP database. The diarrheal compiled by searching DrugBank, GeneCards, OMIM, PharmGkb, TTD databases. intersections drugs disease taken for gene ontology enrichment Kyoto...
Abstract A comprehensive atlas of genes, cell types, and their spatial distribution across a whole mammalian brain is fundamental for understanding function the brain. Here, using snRNA-seq Stereo-seq techniques, we generated mouse with information 308 clusters single-cell resolution involving over 6 million cells as well 29,655 genes. We have identified new astrocyte clusters, demonstrated that distinct exhibit preference cortical subregions. In addition, 155 genes exhibiting regional...
Post-critical seismic waves are widely used in crustal exploration of the velocity structure, and gaining interest oil/gas community to image deeper structure beneath high basalt layer. They featured with their phase shifts strength changes, which should be taken into account data processing, such as analysis true amplitude migration, etc. In order simplify exact but complicated formula reflection transmission coefficients, numerous approximate expressions for coefficients pre-critical...