A5101407532- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neuropharmacology Research
- Genetics, Aging, and Longevity in Model Organisms
- Receptor Mechanisms and Signaling
- Sleep and related disorders
- Metallurgy and Material Forming
- Sleep and Wakefulness Research
- Ubiquitin and proteasome pathways
- Neurobiology and Insect Physiology Research
- Electrocatalysts for Energy Conversion
- Porphyrin and Phthalocyanine Chemistry
- Circadian rhythm and melatonin
- Photoreceptor and optogenetics research
- Advanced Proteomics Techniques and Applications
- Long-Term Effects of COVID-19
- Aluminum Alloys Composites Properties
- Fullerene Chemistry and Applications
- Mitochondrial Function and Pathology
- Photosynthetic Processes and Mechanisms
- COVID-19 and Mental Health
- Dermatology and Skin Diseases
- Neurogenesis and neuroplasticity mechanisms
- SARS-CoV-2 and COVID-19 Research
- Pain Mechanisms and Treatments
- Neuroscience and Neural Engineering
University of California, San Francisco
2019-2023
Broad Center
2019-2023
University of Chinese Academy of Sciences
2014-2018
Chinese Academy of Sciences
2015-2018
Harbin University
2018
Harbin Institute of Technology
2018
Center for Excellence in Brain Science and Intelligence Technology
2016-2018
Shanghai Institutes for Biological Sciences
2014-2016
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) readily infects a variety of cell types impacting the function vital organ systems, with particularly impact on function. Neurological symptoms, which range in severity, accompany as many one-third COVID-19 cases, indicating potential vulnerability neural types. To assess whether human cortical cells can be directly infected by SARS-CoV-2, we utilized stem-cell-derived organoids well primary tissue, both from developmental and...
Serotonergic neurons play key roles in various biological processes. However, circuit mechanisms underlying tight control of serotonergic remain largely unknown. Here, we systematically investigated the organization long-range synaptic inputs to and GABAergic dorsal raphe nucleus (DRN) mice with a combination viral tracing, slice electrophysiological, optogenetic techniques. We found that DRN receive comparable from six major upstream brain areas. Upon further analysis fine functional...
Mesial temporal lobe epilepsy (MTLE) is the most common focal epilepsy. One-third of patients have drug-refractory seizures and are left with suboptimal therapeutic options such as brain tissue-destructive surgery. Here, we report development characterization a cell therapy alternative for drug-resistant MTLE, which derived from human embryonic stem line comprises cryopreserved, post-mitotic, medial ganglionic eminence (MGE) pallial-type GABAergic interneurons. Single-dose intrahippocampal...
Neuronal subtype generation in the mammalian central nervous system is governed by competing genetic programs. The medial ganglionic eminence (MGE) produces two major cortical interneuron (IN) populations, somatostatin (Sst) and parvalbumin (Pvalb), which develop on different timelines. extent to external signals influence these identities remains unclear. Pvalb-positive INs are crucial for circuit regulation but challenging model vitro. We grafted mouse MGE progenitors into diverse 2D 3D...
Prenatal nicotine exposure impairs fetal cortical grey matter volume, but the precise cellular mechanisms remain poorly understood. This study elucidates role of nicotinic acetylcholine receptors (nAChRs) in progenitor cells and radial glia (RG) during human development. We identify two nAChR subunits, CHRNA7 human-specific CHRFAM7A expressed SOX2+ progenitors neurons, with particularly enriched along RG endfeet. activation organotypic slices dissociated cultures increases proliferation...
The generation of neuronal subtypes in the mammalian central nervous system is driven by competing genetic programs. medial ganglionic eminence (MGE) gives rise to two major cortical interneuron (cIN) populations, marked Somatostatin (Sst) and Parvalbumin (Pvalb), which develop on different timelines. extent external signals influence these identities remains poorly understood. Pvalb-positive cINs are particularly important for regulating circuits through strong perisomatic inhibition, yet...
Acetylcholine (ACh) signaling is involved in a wide range of processes, including arousal, attention, and learning. An increasing number studies indicate that cholinergic control these functions highly deterministic, mediated by synaptic afferents generate reliable precise responses postsynaptic neurons. However, mechanisms govern plastic changes strength are poorly understood, even though they likely critical shaping the impact inputs on neuronal networks. We have recently shown thalamic...
An electron mediator inspired by photosynthetic system II was incorporated <italic>via</italic> Zr<sup>4+</sup> ion linkage into a porphyrin sensitized photoanode for water oxidation.
In this work, the hot rolling process of SiCp/2009 Al composites is simulated using fully coupled thermal-stress analysis in Abaqus/Explicit. By investigation formation for along with different fields temperature, strain rate, and stress their evolutionary history, mechanisms under complicated states achieved. The results show that maximum principal changes from compressive to tensile at stage entrance a reverse trend replaces it exit, dominant deformation zone steady stage. temperature drop...