A5100714942- RNA modifications and cancer
- Estrogen and related hormone effects
- RNA and protein synthesis mechanisms
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Genetic Associations and Epidemiology
- MicroRNA in disease regulation
- Glycosylation and Glycoproteins Research
- Genomic variations and chromosomal abnormalities
- Helicobacter pylori-related gastroenterology studies
- Genetic Mapping and Diversity in Plants and Animals
- Mitochondrial Function and Pathology
- Circular RNAs in diseases
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Hormonal Regulation and Hypertension
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Renal and related cancers
- Nutrition, Genetics, and Disease
- Viral Infectious Diseases and Gene Expression in Insects
- Genomics and Chromatin Dynamics
- Bioinformatics and Genomic Networks
- Cancer, Hypoxia, and Metabolism
- Atherosclerosis and Cardiovascular Diseases
University of Arizona
2024-2025
State Key Laboratory of Building Safety and Built Environment
2025
Beijing University of Civil Engineering and Architecture
2025
Zhejiang University
2004-2024
Zhejiang Hospital
2023-2024
Washington University in St. Louis
2009-2023
Sir Run Run Shaw Hospital
2017-2023
University of Massachusetts Lowell
2023
Alvin J. Siteman Cancer Center
2006-2023
Medical College of Wisconsin
2012-2022
PD-L1 up-regulation in cancer contributes to immune evasion by tumor cells. Here, we show that Wnt ligand and activated EGFR induce the binding of β-catenin/TCF/LEF complex CD274 gene promoter region expression, which AKT activation plays an important role. β-Catenin depletion, inhibition, or PTEN expression reduces cells, enhances infiltration CD8+ T growth, accompanied prolonged mouse survival. Combined treatment with a clinically available inhibitor anti–PD-1 antibody overcomes greatly...
Abstract Background Long non-coding RNAs (lncRNAs) are important epigenetic regulators, which play critical roles in diverse physiological and pathological processes. However, the regulatory mechanism of lncRNAs lung carcinogenesis remains elusive. Here, we characterized a novel oncogenic lncRNA, designated as Lung Cancer Associated Transcript 3 (LCAT3). Methods We predicted validated LCAT3 by analyzing RNA-sequencing (RNA-seq) data cancer tissues from TCGA. Methylated RNA...
Nicotine dependence risk and lung cancer are associated with variants in a region of chromosome 15 encompassing genes encoding the nicotinic receptor subunits CHRNA5, CHRNA3 CHRNB4. To identify potential biological mechanisms that underlie this risk, we tested for cis-acting eQTLs CHRNB4 human brain. Using gene expression disease association studies, provide evidence both nicotine-dependence influenced by functional variation CHRNA5. We demonstrated allele rs16969968 primarily occurs on low...
The pathogenesis of ischemic diseases remains unclear. Here we demonstrate the induction microRNA-668 (miR-668) in acute kidney injury (AKI) human patients, mice, and renal tubular cells. was HIF-1 dependent, as deficiency cells proximal tubules attenuated miR-668 expression. We further identified a functional binding site gene promoter. Anti–miR-668 increased apoptosis enhanced AKI whereas mimic protective. Mechanistically, anti–miR-668 induced mitochondrial fragmentation, blocked...
Abstract β-TrCP and SKP2 are two well-studied F-box proteins, which often act as oncogenes. Whether how they communicate with each other is unknown. Here we report that FBXW2, a poorly characterized F-box, substrate of β-TrCP1 an E3 ligase for SKP2. While promotes FBXW2 ubiquitylation shortens its half-life, does the same to has tumour suppressor activity against lung cancer cells blocks oncogenic function both The levels β-TrCP1-FBXW2-SKP2 inversely correlated during cell cycle β-TrCP/SKP2...
Exposure to ionizing radiation during childhood is a well-established risk factor for thyroid cancer. However, the genetic mechanisms of radiation-associated carcinogenesis remain not fully understood.In this study, we used targeted next-generation sequencing and RNA-Seq study 65 papillary cancers (PTCs) from patients in Ukrainian-American cohort with measurement-based iodine-131 (I-131) doses received as result Chernobyl accident. We fitted linear regression models evaluate differences...
Tobacco smoking causes DNA damages in epithelial cells and immune dysfunction the lung, which collectively contribute to lung carcinogenesis progression. However, potential mechanisms by tumor-infiltrating cancer survival their differential contributions ever-smokers never-smokers are not well studied. Here, we performed integrative analysis of 11 gene-expression datasets, including 1,111 adenocarcinomas 200 adjacent normal samples. Distinct pathways were altered never-smokers. Never-smoker...
Transfer RNA-derived fragments (tRFs) are a new class of small non-coding RNAs whose biological roles in cancers not well understood. Emerging evidence suggests that tRFs involved gene regulation at multiple levels. In this study, we constructed an integrative database, OncotRF (http://bioinformatics.zju.edu.cn/OncotRF), for silico exploration tRF functions, and identification diagnostic prognostic biomarkers cancers. The database contains analysis pipeline characterization, results 11,211...
Abstract Purpose: We have previously mapped a major susceptibility locus influencing familial lung cancer risk to chromosome 6q23-25. However, the causal gene at this remains undetermined. In study, we further refined identify single candidate gene, by fine mapping using microsatellite markers and association studies high-density nucleotide polymorphisms (SNP). Experimental Design: Six multigenerational families with five or more affected members were chosen for fine-mapping 6q linkage...
Lung cancer has become the top killer among malignant tumors in China and is significantly associated with somatic genetic alterations. We performed exome sequencing of 14 non–small cell lung carcinomas (NSCLCs) matched adjacent normal tissues extracted from Chinese patients. In addition to cancer–related genes (TP53, EGFR, KRAS, PIK3CA, ROS1), this study revealed “novel” not previously implicated NSCLC. Especially, matrix-remodeling 5 was second most frequently mutated gene NSCLC (first...
Anthocyanins are the most widely produced secondary metabolites in plants, and they play an important role plant growth reproduction. The nitrogen source is factor affecting anthocyanin production, but concentrations on metabolism underlying genetic basis remain unclear. In this study, vitro induction was conducted Malus spectabilis. leaf explants were cultivated media containing different concentrations. results suggested that when contents decreased limit, color of turned from green to...
Hypoxia-inducible factors (HIF-1/2) are fundamental to the development of pulmonary hypertension (PH). Prolonged hypoxia can trigger shift from HIF-1 HIF-2 activity, which is critical in PH progression. Ubiquitin ligases regulate HIF activity through protein degradation. However, little known about if or how these control HIF-1/2 switch associated with We demonstrate that STIP1 homology and U-box containing protein1 (Stub1), an E3 ubiquitin ligase, influences response by suppressing...
With the increasing energy crisis and environmental pollution problems, development of solar-powered photocatalytic technologies for green efficient removal emerging pollutants from aquatic ecosystems has become an urgent need. Bismuth niobate (Bi3NbO7), as a bismuth-based photocatalyst, attracted much attention due to its unique electronic structure optical properties. However, Bi3NbO7 synthesized by traditional hydrothermal method suffers problems large size, limited active sites, harsh...
Clear cell renal carcinoma (ccRCC) is a primary kidney cancer with high aggressive phenotype and extremely poor prognosis.Accumulating evidence suggests that circular RNAs (circRNAs) play pivotal roles in the occurrence development of various human cancers.However, expression, clinical significance regulatory role circRNAs ccRCC remain largely unclear.Here we report circDVL1 to be reduced serums tissues from patients, negatively correlate malignant features.Overexpression inhibits...
Abstract Background Primary liver cancer has significant intratumor genetic heterogeneity (IGH), which drives evolution and prevents effective treatment. CRISPR/Cas9-induced mouse models can be used to elucidate how IGH is developed. However, as CRISPR/Cas9 could induce chromothripsis extrachromosomal DNA in cells addition targeted mutations, we wondered whether this effect contributes the development of cancer. Methods CRISPR/Cas9-based somatic multiplex-mutagenesis was target 34 tumor...
Understanding the genetic basis of common disease and disease-related quantitative traits will aid in development diagnostics therapeutics. The processs gene discovery can be sped up by rapid effective integration well-defined mouse genome phenome data resources. We describe here an silico gene-discovery strategy through genome-wide association (GWA) scans inbred mice with a wide range variation. identified 937 trait loci (QTLs) from survey 173 phenotypes, which include models human...