A5018629756- Thyroid Cancer Diagnosis and Treatment
- Radiation Dose and Imaging
- Cancer-related Molecular Pathways
- Thyroid Disorders and Treatments
- Radioactive contamination and transfer
- Metabolism, Diabetes, and Cancer
- Effects of Radiation Exposure
- Diabetes and associated disorders
- Neurological Disorders and Treatments
- Hormonal Regulation and Hypertension
- Diabetes Management and Research
- Pancreatic function and diabetes
- COVID-19 Clinical Research Studies
- Hormonal and reproductive studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Growth Hormone and Insulin-like Growth Factors
- PI3K/AKT/mTOR signaling in cancer
- Biomarkers in Disease Mechanisms
- Radioactivity and Radon Measurements
- Adrenal Hormones and Disorders
- Diabetes Treatment and Management
- Thyroid and Parathyroid Surgery
- Adipokines, Inflammation, and Metabolic Diseases
- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
V.P. Komisarenko Institute of Endocrinology and Metabolism
2016-2025
National Academy of Medical Sciences of Ukraine
2016-2025
Seoul National University
2025
Macrogen (South Korea)
2025
Seoul National University Bundang Hospital
2025
Charing Cross Hospital
2025
Imperial College London
2025
National Academy of Sciences of Ukraine
2014-2024
Shupyk National Healthcare University of Ukraine
2017-2023
Diabetes Australia
2023
In their previous analysis of papillary thyroid carcinomas (PTCs) from an Ukrainian-American cohort that was exposed to iodine-131 ((131) I) the Chernobyl accident, authors identified RET/PTC rearrangements and other driver mutations in 60% tumors.In this study, remaining mutation-negative tumors were analyzed using RNA sequencing (RNA-Seq) reverse transcriptase-polymerase chain reaction identify novel chromosomal characterize relation with radiation dose.The ETS variant gene 6...
The 1986 Chernobyl nuclear power plant accident increased papillary thyroid carcinoma (PTC) incidence in surrounding regions, particularly for radioactive iodine (
A sharp increase in the incidence of pediatric thyroid papillary cancer was documented after Chernobyl power plant explosion. An increased prevalence rearrangements RET protooncogene (RET/PTC rearrangements) has been reported Belarussian post-Chernobyl carcinomas arising between 1990 and 1995. We analyzed 67 1995–1997 for RET/PTC activation: 28 were from Ukraine 39 Belarus. The study, conducted by a combined immunohistochemistry RT-PCR approach, demonstrated high frequency (60.7% Ukrainian...
Background: The Chornobyl accident in 1986 exposed thousands of people to radioactive iodine isotopes, particularly 131 I; this exposure was followed by a large increase thyroid cancer among those as children and adolescents, Belarus, the Russian Federation, Ukraine. Here we report results first cohort study adolescents following accident. Methods: A 32 385 individuals younger than 18 years age resident most heavily contaminated areas Ukraine at time invited be screened for any pathology...
Current knowledge about Chornobyl-related thyroid cancer risks comes from ecological studies based on grouped doses, case-control studies, and of prevalent cancers.To address this limitation, we evaluated the dose-response relationship for incident cancers using measurement-based individual iodine-131 (I-131) dose estimates in a prospective analytic cohort study.The consists individuals < 18 years age 26 April 1986 who resided three contaminated oblasts (states) Ukraine underwent up to four...
The BRAF gene has been shown to be a major target for mutations in papillary thyroid carcinoma (PTC) (36–69%), which forms almost all of the over 2000 cases that have occurred Chernobyl. is activated by point mutation, and were it occur at high frequency Chernobyl-related tumors, would challenge dominant role double-strand breaks radiation-induced PTC. In previous study, we detected V600E mutation 46% (23 50) sporadic adult Using same methodology, analyzed 34 post-Chernobyl PTC RET/PTC...
Abstract BACKGROUND: Childhood exposure to iodine‐131 from the 1986 nuclear accident in Chernobyl, Ukraine, led a sharp increase papillary thyroid carcinoma (PTC) incidence regions surrounding reactor. Data concerning association between genetic mutations PTCs and individual radiation doses are limited. METHODS: Mutational analysis was performed on 62 diagnosed Ukrainian cohort of patients who were < 18 years old received 0.008 8.6 Gy 131 I thyroid. Associations mutation types dose other...
The increase in the number of childhood thyroid carcinoma cases Ukraine after Chernobyl nuclear accident 1986 prompted development a registry at Institute Endocrinology and Metabolism Kiev. In current study, authors report statistical data clinicomorphologic features included this registry.To study incidence, age gender distribution Ukraine, compiled complete clinical information from diagnosed treated reports submitted to 27 regions Ukraine. Morphologic resected tumors were examined...
A high prevalence of the activating BRAF mutation, BRAFT1796A, is observed in adult papillary thyroid carcinomas (PTCs). The prognosis childhood PTCs generally fairly good despite fact that distant metastases are often documented these cases. To investigate differences between characteristics and PTCs, we analyzed both BRAFT1796A RAS mutations 31 Japanese 48 post-Chernobyl Ukrainian carcinomas. In cases, was found only one instance (3.2%), no were detected. subjects, 15 33 adolescent young...
The large numbers of papillary thyroid carcinomas that have occurred in those exposed to high levels short-lived isotopes fallout after Chernobyl provide a unique opportunity correlate latency and tumour biology. We show short is associated with tumours phenotype significantly less structurally differentiated, shows peritumour fibrosis, more invasive spread when compared longer latent period. In contrast, the type differentiation (papillary or follicular architecture) age at exposure. These...
The nuclear disaster that occurred in Chernobyl 1986 offered the unique opportunity to study molecular genetics of one human tumor type, papillary carcinoma thyroid gland, associated with a specific etiology. We have analyzed RET rearrangements post-Chernobyl carcinomas (n = 29), follicular adenomas 2), and 1) by interphase fluorescence situ hybridization (FISH) analysis on paraffin-embedded tissue sections. Paraffin sections were microdissected before use ensure only was present. Cell...
Jacob, P., Bogdanova, T. I., Buglova, E., Chepurniy, M., Demidchik, Y., Gavrilin, Kenigsberg, J., Meckbach, R., Schotola, C., Shinkarev, S., Tronko, M. D., Ulanovsky, A., Vavilov, S. and Walsh, L. Thyroid Cancer Risk in Areas of Ukraine Belarus Affected by the Chernobyl Accident. Radiat. Res. 165, 1–8 (2006).The purpose present study was to analyze thyroid cancer incidence risk after accident its degree dependence on time age. Data were analyzed for 1034 settlements Belarus, which more than...
<h3>Background:</h3> Several prospective studies have evaluated the association between body mass index (BMI) and cardiovascular mortality among patients with type 2 diabetes; however, results are controversial. <h3>Objective:</h3> To investigate of different BMI distributions total diabetic patients. <h3>Methods:</h3> A 30 534 Ukrainian men 58 909 women diabetes from nationwide population-based register were included in this study. <h3>Results:</h3> During a mean follow-up 2.7 years, 7804...
To evaluate risk of thyroid neoplasia nearly 30 years following exposure to radioactive iodine (I‐131) from the 1986 Chernobyl nuclear accident, we conducted a fifth cycle screening Ukrainian‐American cohort during 2012–2015, four previous cycles started in 1998. We identified 47 cancers (TC) and 33 follicular adenomas (FA) among 10,073 individuals who were <18 at time accident had mean I‐131 dose 0.62 Gy. found significant response for both TC FA, with an excess odd ratio per Gy 1.36...
Exposure to ionizing radiation during childhood is a well-established risk factor for thyroid cancer. However, the genetic mechanisms of radiation-associated carcinogenesis remain not fully understood.In this study, we used targeted next-generation sequencing and RNA-Seq study 65 papillary cancers (PTCs) from patients in Ukrainian-American cohort with measurement-based iodine-131 (I-131) doses received as result Chernobyl accident. We fitted linear regression models evaluate differences...
The increase in thyroid carcinoma post-Chernobyl has been largely confined to a specific subtype of papillary (solid/follicular). This is observed predominantly children under 10 unirradiated populations, but maintains high frequency those aged 10-15 from areas exposed fallout the Chernobyl accident. aim this study was link morphology with molecular biology. We examined 106 carcinomas age 15 at operation. All were for rearrangements RET oncogene by reverse transcription polymerase chain...
Chornobyl Thyroid Diseases Study Group of Belarus, Ukraine, and the USA. A Cohort Cancer Other after Accident: Objectives, Design Methods. Radiat. Res. 161, 481–492 (2004).The thyroid gland in children is one organs that most sensitive to external exposure X γ rays. However, data on risk cancer radioactive iodines are sparse. The accident Ukraine 1986 led large populations iodines, particularly 131I. This paper describes an ongoing cohort study being conducted Belarus includes 25,161...
Like stable iodine, radioiodines concentrate in the thyroid gland, increasing cancer risk exposed children. Data on exposure to embryonic/fetal are rare, raising questions about use of iodine 131 (I-131) pregnant women. We present here estimated risks disease from utero I-131 fallout Chernobyl nuclear accident.