A5057855424- Invertebrate Immune Response Mechanisms
- Aquaculture disease management and microbiota
- Aquaculture Nutrition and Growth
- Antimicrobial Peptides and Activities
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Pluripotent Stem Cells Research
- Cholesterol and Lipid Metabolism
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Neurobiology and Insect Physiology Research
- Molecular Biology Techniques and Applications
- Vibrio bacteria research studies
- DNA Repair Mechanisms
- Phytochemistry and biological activity of medicinal plants
- Renal and related cancers
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Eicosanoids and Hypertension Pharmacology
- Epigenetics and DNA Methylation
- Trace Elements in Health
- Single-cell and spatial transcriptomics
- CRISPR and Genetic Engineering
- Cell death mechanisms and regulation
- Cancer-related gene regulation
Ocean University of China
2025
Shantou University
2017-2024
East China Normal University
2024
Shanghai Ocean University
2024
Marine Biology Institute of Shandong Province
2021-2023
China Medical University
2008-2022
Shell (Malaysia)
2021-2022
Universiti Malaysia Terengganu
2021-2022
Women's Hospital, School of Medicine, Zhejiang University
2020
Fujian Medical University
2004-2020
PD-L1 up-regulation in cancer contributes to immune evasion by tumor cells. Here, we show that Wnt ligand and activated EGFR induce the binding of β-catenin/TCF/LEF complex CD274 gene promoter region expression, which AKT activation plays an important role. β-Catenin depletion, inhibition, or PTEN expression reduces cells, enhances infiltration CD8+ T growth, accompanied prolonged mouse survival. Combined treatment with a clinically available inhibitor anti–PD-1 antibody overcomes greatly...
Alzheimer's disease (AD) is pathologically characterized by deposition of β-amyloid (Aβ) peptides, which closely correlates with the balance nerve growth factor (NGF)-related TrkA/p75NTR signaling. (-)-Epigallocatechin-3-gallate (EGCG) used for prevention and treatment many neurodegenerative diseases, including AD. However, whether neuroprotective effects EGCG were via modulating signaling was still unknown. In this study, we found that (2 mg·kg(-1)·day(-1)) dramatically ameliorated...
A small portion of cytoplasm is generally retained as the cytoplasmic droplet (CD) on flagellum spermatozoa after spermiation in mice. CDs are believed to play a role osmoadaptation by allowing water entrance or exit. However, many lines evidence suggest that may have roles beyond osmoregulation. To gain more insights, we purified from murine epididymal and conducted proteomic analyses proteins highly enriched CDs. Among 105 identified, 71 (68%) were enzymes involved energy metabolism. We...
Although the cytoplasm of spermatids is removed at end spermiogenesis, a tiny portion usually retained in sperm flagellum, which termed cytoplasmic droplet (CD) mammals.CDs are believed to play role volume adaptation.However, we have noticed that epididymal spermatozoa display initial (flagellation situ) and progressive motility mostly possess CDs, whereas without CDs rarely motile, suggesting development during maturation.In present study, analyzed relationship between presence or absence...
Hemocyanin, the multifunctional glycoprotein in hemolymph of invertebrates, can generate various antimicrobial peptides (AMPs). Given rising interest use natural therapeutic agents such as AMPs, alternative and more efficient methods for their generation are being explored. In this work, free online software was first applied to predict from large subunit Litopenaeus vannamei hemocyanin. Twenty potential ranging 1.5 1.9 kDa were predicted, five which had α-helical structures selected...
Acute hepatopancreatic necrosis disease (AHPND) has emerged as a major debilitating that causes massive shrimp death resulting in substantial economic losses aquaculture. Given several diseases and infections have been associated with microRNAs (miRNAs), we conducted comparative transcriptomic analysis using the AHPND (VA) non-AHPND (VN) strains of Vibrio parahemolyticus to identify miRNAs potentially involved pathogenesis Litopenaeus vannamei. A total 83 (47 upregulated 36 downregulated)...
Abstract Background Numerous microorganisms are found in aquaculture ponds, including several pathogenic bacteria. Infection of cultured animals by these pathogens results diseases and metabolic dysregulation. However, changes the profiles that occur at different infection stages same ponds how can be modulated exogenous metabolites Penaeus vannamei remain unknown. Results Here, we collected gastrointestinal tract (GIT) samples from healthy, diseased, moribund P. pond for histological,...
Evolutionarily conserved SCAN (named after SRE-ZBP, CTfin51, AW-1, and Number 18 cDNA)-domain-containing zinc finger transcription factors (ZSCAN) have been found in both mouse human genomes. Zscan4 is transiently expressed during zygotic genome activation (ZGA) preimplantation embryos induced pluripotent stem cell (iPSC) reprogramming. However, little known about the mechanism of underlying these processes fate control. Here, we show that Zscan4f, a representative ZSCAN proteins, able to...
Aim: To evaluate the association of ABCB1 gene polymorphisms with susceptibility to colorectal cancer (CRC) and clinical outcomes CRC patients chemotherapy. Patients & methods: A case–control study was performed on C3435T, C1236T G2677T/A in 1028 1230 controls. Results: We observed that C3435T variants as well 3435T–1236T–2677T haplotype significantly increased risk CRC. The CT genotype had a significant effect time recurrence (adjusted hazard ratio [HR; 95% CI]: 0.560 [0.355–0.882]; p =...
Aquatic organisms have to produce proteins or factors that help maintain a stable relationship with microbiota and prevent colonization by pathogenic microorganisms. In crustaceans other aquatic invertebrates, relatively few of these host been characterized. this study, we show the respiratory glycoprotein hemocyanin is crucial factor modulates microbial composition diversity in hepatopancreas penaeid shrimp. Diseased shrimp (Penaeus vannamei), had an empty gastrointestinal tract atrophied...
ABSTRACT The low-density lipoprotein receptor (LDLR) plays a critical role in the liver for clearance of plasma (LDL). Its deficiency causes hypercholesterolemia many models. To facilitate usage rats as animal models discovery cholesterol-lowering drugs, we took genetic approach to delete LDLR aiming increase LDL cholesterol (LDL-C). An knockout rat was generated via zinc-finger nuclease technology, which harbors 19-basepair deletion seventh exon ldlr gene. As expected, elevated total and...
Anthropogenic factors and climate change have serious effects on the aquatic ecosystem aquaculture. Among water pollutants, ammonia has greatest impact aquaculture organisms such as penaeid shrimp because it makes them more susceptible to infections. In this study, we explored of stress (0, 50, 100, 150 mg/L) molecular structure functions multifunctional respiratory protein hemocyanin (HMC) in Penaeus vannamei. While mRNA expression vannamei (PvHMC) was up-regulated after stress, both plasma...