A5045904585- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- Photoreceptor and optogenetics research
- Neurological disorders and treatments
- Tryptophan and brain disorders
- Sleep and related disorders
- Ion channel regulation and function
- Sleep and Work-Related Fatigue
- Enhanced Recovery After Surgery
- Stoma care and complications
- RNA Research and Splicing
- Advanced Memory and Neural Computing
- Atrial Fibrillation Management and Outcomes
- Nerve injury and regeneration
- Muscle Physiology and Disorders
- Colorectal Cancer Surgical Treatments
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Conducting polymers and applications
- Neurobiology and Insect Physiology Research
- Bariatric Surgery and Outcomes
- Cellular transport and secretion
Shanghai Jiao Tong University
2017-2024
First Affiliated Hospital of Jiamusi University
2017-2023
Bridge University
2023
Development Research Center
2023
Jiamusi University
2022-2023
Shanghai Mental Health Center
2022
The University of Texas Southwestern Medical Center
2010-2019
Southwestern Medical Center
2011-2019
Shandong Provincial Hospital
2018
Huaian First People’s Hospital
2018
Alzheimer's disease (AD) is pathologically characterized by deposition of β-amyloid (Aβ) peptides, which closely correlates with the balance nerve growth factor (NGF)-related TrkA/p75NTR signaling. (-)-Epigallocatechin-3-gallate (EGCG) used for prevention and treatment many neurodegenerative diseases, including AD. However, whether neuroprotective effects EGCG were via modulating signaling was still unknown. In this study, we found that (2 mg·kg(-1)·day(-1)) dramatically ameliorated...
Abstract Background Inflammation-related predisposition to cancer plays an essential role in progression and is associated with poor prognosis. A hypoxic microenvironment neutrophil infiltration are commonly present solid tumours, including gastric (GC). Neutrophil extracellular traps (NETs) have also been demonstrated the tumour immune (TIME), but how NETs affect GC remains unknown. Here, we investigated of NET formation TIME further explored underlying mechanism growth. Methods...
The aqueous MeOH extract of the leaves and root Xanthocercis zambesiaca (Leguminosae) eight structurally related nitrogen-containing sugars, fagomine (1), 4-O-beta-D-glucopyranosylfagomine (2), 3-O-beta-D-glucopyranosylfagomine (3), 3-epifagomine (4), 2,5-dideoxy-2,5-imino-D-mannitol (5), castanospermine (6), alpha-homonojirimycin (7), 1-deoxynojirimycin (8) were evaluated for antihyperglycemic effects in streptozotocin (STZ)-diabetic mice. insulin-releasing 1 also investigated. blood...
The enzyme ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) is one of the most abundant proteins in mammalian nervous system. In humans, UCH-L1 also found ubiquitinated inclusion bodies that characterize neurodegenerative diseases brain, suggesting its involvement neurodegeneration. physiologic role neurons, however, remains to be further elucidated. For example, previous studies have provided evidence both for and against synaptic function brain. Here, we characterized a line knockout mice...
Many chronic neuroscience studies require neural probes that can reliably record with a large number of electrodes in densely configured array. Previous works have shown adverse tissue reaction be significantly reduced as probe shanks are scaled down toward subcellular dimensions. In addition, flexible mitigate shear stress-induced damage due to micromotion. However, both size reduction and flexibility compromise probe's ability penetrate the pia mater, especially when many distributed...
Abstract Background AUF1 is one of the AU‐rich binding proteins, which promotes rapid ARE‐mRNA degradation. Recently, it has been reported that involved in regulating antioxidant system because its capacity to bind specifically RNA containing oxidized bases and degrade RNA. Many proteins have be overexpressed colorectal cancer (CRC), however, role progression CRC not explored. Methods The expression level protein human cell lines tissues was detected by western blotting immunohistochemistry...
MutT-related proteins, including MTH1, MTH2, MTH3 and NUDT5, can effectively degrade 8-oxoGua-containing nucleotides. The MTH1 expression is elevated in many types of human tumors overexpression correlates with the tumor pathological stage poor prognosis. However, other proteins cancers remains unknown. present study systematically investigated NUDT5 colorectal cancer to establish its clinical significance.Amounts mRNA protein CRC cell lines were assessed by qRT-PCR Western blotting,...
The antihyperglycaemic interaction (blend effect) of component crude drugs included in a traditional Chinese prescription, Byakko-ka-ninjin-to (BN; consisted five drugs, ginseng, anemarrhena,-licorice, gypsum and rice) was investigated using genetically obese diabetic KK-CA(y) mice alloxan-diabetic mice. water extract anemarrhena, licorice when individually tested markedly lowered blood glucose levels animals. Antihyperglycaemic effects ginseng-anemarrhena ginseng-licorice combinations were...
Many chronic brain implants would benefit from a neural probe with many densely configured electrodes stable recording quality. We present novel strategy to scale up the number of minimized risk proportionally increasing adverse foreign body reactions. A flexible parylene having 64 has been designed and fabricated unique geometries for reduced tissue Biocompatible silk fibroin was patterned provide biodegradable mechanical support during insertion. validated design in vivo rats observed no...
Abstract Background The quality of learning and post-learning performances is critical for daily life. behavioral flexibility equally important adapting the changing circumstances. process requires repeated practices, which enhances prompt proper responses, in turn, promotes habits formation as well. Despite well-documented sex differences performances, contradictory results were reported. A possible cause might be a systematic analysis due to specific research interests, regardless...
Abstract Both non‐rapid eye movement (NonREM) sleep and rapid (REM) sleep, as well spindle ripple oscillations, are important for memory formation. Through cortical EEG recordings of prefrontal cortex hippocampus during after an inhibitory avoidance task, we analysed the dynamic changes in amounts oscillations related to The total amount NonREM was reduced first hour learning. Moreover, significant decrease counts observed at learning well. In addition, foot shock alone, with no associated...
Schwann cells are integral components of vertebrate neuromuscular synapses; in their absence, pre-synaptic nerve terminals withdraw from post-synaptic muscles, leading to muscle denervation and synapse loss at the developing junction (NMJ). Here, we report a rescue synapses type III Neuregulin 1 mutant mice (CRD-Nrg1−/−), which lack cells. We found that were prevented CRD-Nrg1−/−mice when presynaptic activity was blocked by ablating specific gene, such as Snap25 (synaptosomal-associated 25...
Background The population in Jiamusi has been reported to have the highest prevalence of colorectal cancer (CRC) China. genetic causal-effect for this occurrence among residents remains unclear. Given long cold seasons with people wearing more clothes and reduced UV exposure, we aimed study association between vitamin D metabolism-related gene CYP24A1 polymorphism CRC susceptibility. Method A case-control was conducted that included 168 patients 710 age-matched healthy individuals as control...
BACKGROUND:Colorectal cancer (CRC) is the second most commonly diagnosed in females and third males worldwide. Although existing evidence explained some critical functions of single genetic abnormality pathogenesis CRC, function interactors involved colon-specific regulatory network, especially DNA methylation regulated network still poorly understood. MATERIAL AND METHODS:In this work, matched gene expression samples CRC patients were retrieved. Differential analyses performed. In addition,...
Studies have implied that the circadian oscillation of mitogen-activated protein kinase (MAPK) signal pathways is crucial for hippocampus-dependent memory. NF1 mouse models (Nf1 heterozygous null mutants; Nf1 +/−) displayed enhanced MAPK activity in hippocampus and resulted memory deficits. We assumed a link between hippocampal rhythmic oscillations, which never been explored +/− mice. demonstrated level extracellular signal–regulated kinases 1 2 (ERK1/2) phosphorylation mice were...
In this reported work, a modified decoding and detection scheme with dispersion compensation is investigated for spectral‐amplitude‐coding optical code division multiple access (SAC‐OCDMA) systems. For simultaneously compensating the chromatic of signals in 40 km‐long standard single‐mode fibre transmission, based on reconstruction equivalent‐chirp method array configuration Bragg grating (FBG) segments can be controlled quadratic −680 ps/nm an extra time delay. The traditional triple‐branch...