A5100328324- RNA modifications and cancer
- Alzheimer's disease research and treatments
- Bipolar Disorder and Treatment
- Child and Adolescent Psychosocial and Emotional Development
- Neuroinflammation and Neurodegeneration Mechanisms
- Gut microbiota and health
- Attention Deficit Hyperactivity Disorder
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Cancer-related molecular mechanisms research
- Neuroscience and Neuropharmacology Research
- Schizophrenia research and treatment
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Memory and Neural Mechanisms
- Genetic Associations and Epidemiology
- Gastroesophageal reflux and treatments
- Genetics and Neurodevelopmental Disorders
- Tryptophan and brain disorders
- Mental Health Treatment and Access
- Neurotransmitter Receptor Influence on Behavior
- Neurogenesis and neuroplasticity mechanisms
- Cancer, Hypoxia, and Metabolism
Zhengzhou University
2022-2025
Peking University
2005-2024
Ruijin Hospital
2015-2024
Shanghai Jiao Tong University
2013-2024
National Computer Network Emergency Response Technical Team/Coordination Center of Chinar
2024
Shanghai Institute of Hematology
2011-2024
Fudan University
2024
Guangzhou University of Chinese Medicine
2022-2024
Sichuan Agricultural University
2024
King's College London
2024
Despite evidence of the increasing use psychotropic medications, little is known about broader changes in delivery outpatient mental health treatment to children, adolescents, and adults.To assess national trends patterns care adults office-based medical practice.Outpatient visits physicians practice from 1995-2010 National Ambulatory Medical Care Surveys (N = 446 542). Trends (1995-2010) with indicators are first compared between youths (<21 years) (≥21 then children (0-13 adolescents...
<h3>Context</h3>Although antipsychotic treatment has recently increased, little is known about how this development differentially affected the office-based care of adults and young people in United States.<h3>Objective</h3>To compare national trends patterns youths medical practice.<h3>Design</h3>Trends between 1993 2009 visits with antipsychotics for children (0-13 years), adolescents (14-20 (≥21 years) are described on a per population basis as proportion total office visits. Background...
Protein-coding genetic variants that strongly affect disease risk can yield relevant clues to pathogenesis. Here we report exome-sequencing analyses of 20,791 individuals with type 2 diabetes (T2D) and 24,440 non-diabetic control participants from 5 ancestries. We identify gene-level associations rare (with minor allele frequencies less than 0.5%) in 4 genes at exome-wide significance, including a series more 30 SLC30A8 alleles conveys protection against T2D, 12 gene sets, those...
Article AbstractObjective: To assess recent national trends in mental health care provided by office-based psychiatrists and primary physicians. Method: Trends health-related visits to physicians are evaluated with the 1995-2010 National Ambulatory Medical Care Surveys. Rates percentages of complaints, disorder diagnoses, psychotropic medications, psychotherapy or counseling were calculated for 1995-1998, 1999-2002, 2003-2006, 2007-2010 dividing number a given type intercensal population...
Aims: The N6-methyladenosine (m6A) modification plays an important role in various biological processes, but its atherosclerosis remains unknown. aim of this study was to investigate the and mechanism m6A endothelial cell inflammation influence on development. Methods: We constructed a stable TNF-α-induced model assessed changes expression modification-related proteins identify major factors involved process. m6A-modified mRNAs were identified by methylated RNA immunoprecipitation (RIP)...
-methyladenosine (m
Article Abstract Background: Cross-sectional studies demonstrate increased prevalence of cardiovascular disease (CVD) among adults with bipolar disorder. However, there is a paucity prospective data regarding new-onset CVD Method: Analyses compared the 3-year incidence (via participant-reported physician diagnoses) participants DSM-IV diagnoses I disorder (n = 1,047), II 392), major depressive (MDD; n 4,396), or controls 26,266), who completed Wave 1 (2001-2002) and 2 (2004-2005) National...
Reports of a recent increase in US outpatient mental health care raise questions about whether it has been driven by rising rates psychological distress and treatment become either more or less focused on people with higher levels distress.To characterize national trends serious service use adults without distress.The 2004-2005, 2009-2010, 2014-2015 Medical Expenditure Panel Surveys (MEPS) were nationally representative surveys taken households. The analysis was limited to participants 18...
Abstract Background The BIN1 locus contains the second-most significant genetic risk factor for late-onset Alzheimer’s disease. undergoes alternate splicing to generate tissue- and cell-type-specific isoforms, which regulate membrane dynamics in a range of crucial cellular processes. Whilst expression brain has been characterized neurons oligodendrocytes detail, information regarding microglial is mainly limited large-scale transcriptomic proteomic data. Notably, protein its functional roles...
Glioblastoma (GBM), an aggressive brain malignancy with a cellular hierarchy dominated by GBM stem cells (GSCs), evades antitumor immunity through mechanisms that remain incompletely understood. Like most cancers, GBMs undergo metabolic reprogramming toward glycolysis to generate lactate. Here, we show lactate production patient-derived GSCs and microglia/macrophages induces tumor cell epigenetic histone lactylation, activating modification leads immunosuppressive transcriptional programs...
Article AbstractObjective: Although psychiatric disorders are associated with decreased health-related quality of life, it is unknown whether symptom remission its improvement or normalization.Method: Data were derived from the National Epidemiologic Survey on Alcohol and Related Conditions, a large national sample United States population. A total 34,653 adults 18 years older residing in households completed 2 waves (2001-2002 2004-2005) face-to-face surveys. DSM-IV diagnoses mood, anxiety,...
Abstract There is an increasing risk of mental disorders, such as acute stress disorder (ASD), post-traumatic (PTSD) and depression among survivors who were trapped in rubble during earthquake. Such long-term impaction a single restraint has not been extensively explored. In this study, we subjected mice to 24-hour-restraint simulate the trapping episode, investigated (2 days after restraint) (35 impacts. Surprisingly, found that displayed depression-like behaviors, decreased glucose uptake...
Stress sensitization, whereby CA lowers tolerance to later stressors, has been proposed as a potential mechanism explaining the association between exposure childhood adversities (CA) and drug use disorders in adulthood. However, this remains untested. This paper begins address gap through exploring associations stressful events adulthood for predicting disorders. We used data drawn from Wave 2 of U.S. National Epidemiological Survey Alcohol Related Conditions (n = 34,653) explore whether...
Herpes simplex encephalitis (HSE), a complication of herpes virus type I (HSV-1) infection causes neurological disorder or even death in immunocompromised adults and newborns. However, the intrinsic factors controlling HSE outcome remain unclear. Here, we show that mice exhibit gut microbiota dysbiosis altered metabolite configuration tryptophan-nicotinamide metabolism. HSV-1 neurotropic activated microglia, with changed immune properties cell numbers, to stimulate antiviral response...
Background Substantial evidence suggests an association between psychiatric disorders and chronic heart failure. However, further investigation is needed to confirm the causal relationship these To address this, we evaluated potential effects of five on failure using two-sample Mendelian Randomization (MR). Methods We selected single nucleotide polymorphisms (SNPs) associated with (Attention-Deficit Hyperactivity Disorder (ADHD), Autism Spectrum (ASD), Major Depression, Bipolar Schizophrenia...
A significant association between attention-deficit hyperactivity disorder (ADHD) and obesity has been reported. This study addresses unexplored aspects of this relationship.To evaluate the adult and: (a) persistent, remitted or lifetime ADHD; (b) number childhood ADHD symptoms, controlling for socioeconomic status mood, anxiety substance use disorders.Face-to-face psychiatric interviews in 34 653 US adults from National Epidemiologic Study on Alcohol Related Conditions. Obesity was defined...