A5037005622- Cancer, Lipids, and Metabolism
- CAR-T cell therapy research
- Diverse Aspects of Tourism Research
- Cancer, Hypoxia, and Metabolism
- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- RNA modifications and cancer
- Head and Neck Surgical Oncology
- Eicosanoids and Hypertension Pharmacology
- Immune Cell Function and Interaction
- Cruise Tourism Development and Management
- Air Traffic Management and Optimization
- Consumer Behavior in Brand Consumption and Identification
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Chromatin Remodeling and Cancer
- Higher Education Governance and Development
- Advanced biosensing and bioanalysis techniques
- Single-cell and spatial transcriptomics
- International Student and Expatriate Challenges
- Information Retrieval and Data Mining
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Epilepsy research and treatment
- Sport and Mega-Event Impacts
University of Pittsburgh Medical Center
2022-2024
UPMC Hillman Cancer Center
2022-2024
University High School
2024
University of California, San Diego
2019-2022
University of Pittsburgh
2022
Singapore Institute of Management
2019-2021
Singapore Management University
2021
St. Francis Xavier University
2021
Sanford Consortium for Regenerative Medicine
2020
California State University, Fullerton
2020
Brain tumors are dynamic complex ecosystems with multiple cell types. To model the brain tumor microenvironment in a reproducible and scalable system, we developed rapid three-dimensional (3D) bioprinting method to construct clinically relevant biomimetic tissue models. In recurrent glioblastoma, macrophages/microglia prominently contribute mass. parse function of macrophages 3D, compared growth glioblastoma stem cells (GSCs) alone or astrocytes neural precursor hyaluronic acid-rich...
Glioblastoma ranks among the most aggressive and lethal of all human cancers. Functionally defined glioma stem cells (GSC) contribute to this poor prognosis by driving therapeutic resistance maintaining cellular heterogeneity. To understand molecular processes essential for GSC maintenance tumorigenicity, we interrogated superenhancer landscapes primary glioblastoma specimens in vitro GSCs. GSCs epigenetically upregulated ELOVL2, a key polyunsaturated fatty-acid synthesis enzyme. Targeting...
<h3>Objectives</h3> Long-term night work has been suggested as a risk factor for breast cancer; however, additional studies with more comprehensive methods of exposure assessment to capture the diversity shift patterns are needed. As well, few previous have considered role hormone receptor subtype. <h3>Methods</h3> Relationships between and cancer were examined among 1134 cases 1179 controls, frequency-matched by age in Vancouver, British Columbia, Kingston, Ontario. Self-reported lifetime...
To evaluate implementation of an enhanced recovery after surgery (ERAS) program for patients undergoing elective cesarean delivery by comparing opioid exposure, multimodal analgesia use, and other process outcome measures before implementation.An ERAS was implemented among in a large integrated health care system. We conducted pre-post study to compare changes during the 12 months implementation.The included 4,689 who underwent (pilot sites: March 1, 2015-February 29, 2016, all October...
Acute myeloid leukemia (AML) is an aggressive disease with a poor prognosis (5-year survival rate of 30.5% in the United States). Designing cell therapies to target AML challenging because no single tumor-associated antigen (TAA) highly expressed on all cancer subpopulations. Furthermore, TAAs are also healthy cells, leading toxicity risk. To address these targeting challenges, we engineer natural killer (NK) cells multi-input gene circuit consisting chimeric receptors (CARs) controlled by...
In microbial communities, bacterial populations are commonly controlled using indiscriminate, broad range antibiotics. There few ways to target specific strains effectively without disrupting the entire microbiome and local environment. Here, we use conjugation, a natural DNA horizontal transfer process among species, deliver an engineered CRISPR interference (CRISPRi) system for targeting genes in recipient Escherichia coli cells. We show that delivery of CRISPRi is successful can...
Abstract Meningiomas are the most common primary intracranial tumor with current classification offering limited therapeutic guidance. Here, we interrogated meningioma enhancer landscapes from 33 tumors to stratify patients based upon prognosis and identify novel meningioma-specific dependencies. Enhancers robustly stratified meningiomas into three biologically distinct groups (adipogenesis/cholesterol, mesodermal, neural crest) distinguished by hormonal lineage transcriptional regulators....
DPY30 is an in vivo–specific dependency glioblastoma that regulates phosphodiesterases and angiogenesis the hypoxic tumor microenvironment.
Glioblastoma ranks among the most aggressive and lethal of all human cancers. Self-renewing, highly tumorigenic glioblastoma stem cells (GSCs) contribute to therapeutic resistance maintain cellular heterogeneity. Here, we interrogated superenhancer landscapes primary specimens patient-derived GSCs, revealing a kelch domain-containing gene, specifically Kelch domain containing 8A (KLHDC8A) with previously unknown function as an epigenetically driven oncogene. Targeting KLHDC8A decreased GSC...
This study aims to assess the level of casino tourism development as perceived by residents Grand Ho Tram Strip in Vietnam. is timely and crucial because local government needs make a decision regarding extension based on residents' opinions about responsible or sustainable development, taking wellbeing their futures into consideration. Positive economic impacts did not entail satisfaction community. Other structural paths were all significant explaining resultant variables signs...
Acute Myeloid Leukemia (AML) with FLT3 (FMS-like Tyrosine Kinase 3) mutations poses a significant challenge in oncology. This paper explores the potential of combined treatment approach involving CRISPR/Cas9 gene editing and CAR T-cell therapy. technology can precisely target correct mutation responsible for AML proliferation. Simultaneously, therapy harnesses immune system to FLT3-mutated cells using engineered T cells. While promising, these approaches come challenges, such as off-target...
We identified the most effective mix of school-based policies, programs, and regional environments associated with low school smoking rates in a cohort Canadian high schools over time.We collected comprehensive set student, school, community data from national 51 2004 2007. Hierarchical linear modeling was used to predict characteristics prevalence.Between 2007, prevalence decreased 13.3% 10.7% schools. Predictors lower included both related prevention programming characteristics, including...
Purpose The purpose of this paper is to build on both the theoretical work concerning co-creation experiences, and need for micro-businesses adopt a consumer-friendly orientation. researchers examined compatibility vendors’ views their visitors’ perspectives own assessments two Hong Kong night markets. Using large sample survey with over 1,900 tourists 120 vendors, examining data through mean difference testing factor analysis, comparability was examined. Key findings were that vendors...
Improved safety and increased capacity are usually viewed as conflicting goals. The recent Gore Commission report set a goal for civil aviation of reducing the accident rate by factor five over ten years while enabling capacity. In order to achieve these goals, new technologies procedures will have be introduced. Many initiatives related safety-critical approach landing other terminal area operations. There is currently no accepted method quantify relationship between levels, aircraft...
Abstract CAR-based cell therapies have revolutionized cancer treatment, however, applications beyond targeting lineage antigens are challenging due to expression of targeted in healthy cells posing a risk for on-target off-tissue toxicities. This presents an opportunity leverage synthetic biological logic gated gene circuits, such as NOT gate, expand targets therapies. We constructed first-in-class gate CAR-NK protect from CAR-mediated cytotoxicity. An inhibitory CAR (iCAR) recognizes safety...
The purpose of writing this paper is to analyze the e-commerce system on largest online shopping site in Indonesia, Shopee. co.id. analysis includes, advantages and disadvantages Shopee Indonesia SWOT site. Analysis result shows that able become company with a variety service transaction security guarantees. However, also still has some weaknesses, including regarding system, many consumers experiencing fraud. uses inovation strategies bargaining power suppliers make it Indonesia.
The international demand for tertiary education has grown tremendously as enrolment increased from a mere 6.5 million in 1950 to 88 2000 (Larsen & Vincent-Lancrin, 2002). Boehm et al (2002) predicted that by 2025, there will be 7 students studying overseas compared 1.4 the early 1990s. This research focus on identifying underlying factors influencing decision of China and India pursue at Australian institutes higher located Singapore. study expands six factor model (Mazzarol, 1997)...
The purpose of this paper is to report new trends in tourism research. considers studies account stakeholder evaluations Integrated resorts (IRs) Singapore, deviant visitor behaviours at tourist attractions and the emergence consumer desire experience an unplugged interruption free holiday. attempts stimulate researchers explores directions management.