A5101894710- Cardiac, Anesthesia and Surgical Outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood Coagulation and Thrombosis Mechanisms
- Genetic Associations and Epidemiology
- Bariatric Surgery and Outcomes
- Global Health Care Issues
- Cancer, Hypoxia, and Metabolism
- Diabetes Management and Education
- Healthcare Systems and Reforms
- Cardiovascular Health and Risk Factors
- Metabolism, Diabetes, and Cancer
- Bone and Joint Diseases
- Hip disorders and treatments
- Gestational Diabetes Research and Management
- Blood Pressure and Hypertension Studies
- Healthcare Policy and Management
- Nutritional Studies and Diet
- Genetic Mapping and Diversity in Plants and Animals
- Bone health and treatments
- Lipid metabolism and disorders
- Genetics and Plant Breeding
- Venous Thromboembolism Diagnosis and Management
- Lymphoma Diagnosis and Treatment
- Enhanced Recovery After Surgery
- Neonatal and Maternal Infections
First Affiliated Hospital of Wenzhou Medical University
2023-2025
Wenzhou Medical University
2023-2025
ShanghaiTech University
2024
Boai Hospital of Zhongshan
2024
Community Link
2019-2023
Kaiser Permanente
2019-2023
Beijing Anzhen Hospital
2018-2022
Capital Medical University
2022
Weatherford College
2022
Zhengzhou University
2016-2021
To evaluate implementation of an enhanced recovery after surgery (ERAS) program for patients undergoing elective cesarean delivery by comparing opioid exposure, multimodal analgesia use, and other process outcome measures before implementation.An ERAS was implemented among in a large integrated health care system. We conducted pre-post study to compare changes during the 12 months implementation.The included 4,689 who underwent (pilot sites: March 1, 2015-February 29, 2016, all October...
To evaluate perinatal outcomes associated with pregnancy after bariatric surgery within a large integrated health care system using propensity score matching.We conducted retrospective cohort study that evaluated in pregnant patients from January 2012 through December 2018. History of was identified by International Classification Diseases codes and clinical database. Primary were preterm birth (PTB), gestational hypertension, preeclampsia, impaired glucose tolerance or diabetes,...
Cerebral venous sinus thrombosis (CVST) is a rare and atypical thrombotic condition, particularly prevalent among young adults, with complex cause. In July October 2023, two patients were diagnosed hereditary protein S deficiency (PSD) presenting CVST at the Department of Neurology, first affiliated hospital Wenzhou Medical University. This study analysed phenotypes gene mutations in PSD pedigrees to investigate link between CVST. A total 11 individuals from these involved. We measured...
Sanglifehrin A (SFA), a potent cyclophilin inhibitor produced by Streptomyces flaveolus DSM 9954, bears unique [5.5] spirolactam moiety conjugated with 22-membered, highly functionalized macrolide through linear carbon chain. SFA displays diverse range of biological activities and offers significant therapeutic potential. However, the structural complexity poses tremendous challenge for new analogue development via chemical synthesis. Based on rational prediction its biosynthetic origin,...
Abstract Objective Prediabetes and lifestyle factors have been associated with the risks of multiple adverse outcomes, but effect a healthy on prediabetes‐related complications remains unknown. We aimed to investigate whether outcomes including incident type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), chronic kidney (CKD) among individuals prediabetes can be offset by broad combination factors. Methods This prospective study used data from UK Biobank cohort. An overall score...
The prevalence of chronic non-communicable diseases (NCDs) challenges the Chinese health system reform. Little is known for differences in catastrophic expenditure (CHE) between urban and rural households with NCD patients. This study aims to measure above quantify contribution each variable explaining urban-rural differences.Unbalanced panel data were obtained from China Family Panel Studies (CFPS) conducted 2012 2018. techniques Fairlie nonlinear decomposition Blinder-Oaxaca employed...
Objective This study was designed to investigate the impact of body mass index (BMI) on short- and long-term outcomes after initial revascularization with coronary artery bypass graft (CABG) surgery. Methods 4916 Chinese who consecutively underwent isolated, primary CABG at Cardiovascular Institute Fuwai Hospital from January 1, 1999 December 31, 2005 were included in this study. They classified based BMI as follows: underweight: <18.5 kg/m2, normal weight: 18.5 23.9 overweight: 24 27.9...
Abstract The purpose of this study was to establish a simple and effective risk score for type 2 diabetes mellitus (T2DM) in middle-aged rural Chinese. Total 5453 participants aged 30–59 years from the Rural Diabetes, Obesity Lifestyle (RuralDiab) were recruited establishing RuralDiab by using logistic regression analysis. validated prospective Henan Province China, compared with previous scores receiver-operating characteristics cure. Ultimately, sex, age, family history diabetes, physical...
Various hypertension predictive models have been developed worldwide; however, there is no existing model for among Chinese rural populations.This a 6-year population-based prospective cohort in areas of China. Data was collected 2007-2008 (baseline survey) and 2013-2014 (follow-up from 8319 participants ranging age 35 to 74 years old. Specified gender were established based on multivariate Cox regression, Artificial Neural Network (ANN), Naive Bayes Classifier (NBC), Classification...
Oxidative stress is thought to contribute cancer development. Epstein-Barr virus (EBV) and its encoded oncoprotein, latent membrane protein 1 (LMP1), are closely associated with the transformation of nasopharyngeal carcinoma (NPC) Burkitt's lymphoma (BL). In this study, we used LMP1-transformed NP cells EBV-related malignant cell lines assess effects LMP1 on reactive oxygen species (ROS) accumulation glycolytic activity. Using NPC tissue samples a array address clinical implications, report...
Pulmonary artery catheters (PAC) are used widely to monitor hemodynamics in patients undergoing coronary bypass graft (CABG) surgery. However, recent studies have raised concerns regarding both the effectiveness and safety of PAC. Therefore, our aim was determine effects use PAC on short- long-term health economic outcomes CABG.1361 Chinese who consecutively underwent isolated, primary CABG at Cardiovascular Institute Fuwai Hospital from June 1, 2012 December 31, were included this study. Of...
To study changes in blood lipid metabolism sepsis patients, especially high-density lipoprotein cholesterol (HDL-C) the diagnosis of and type bacteria involved.Two-hundred-twenty cases patients with febrile infections were divided into local infection, systemic inflammatory response syndrome or (sepsis) group. For controls, 81 a healthy check-up used. Lipid levels state supervised, comparative analysis admitted to hospital after 1, 5, 10 days was performed.In sepsis, total cholesterol,...
Getting medical treatment is still difficult and expensive in western China. Improving the equity of basic health services one tasks new healthcare reform This study aimed to analyze parallel vertical service utilization urban residents then find its influencing factors.In August 2011, a household survey was conducted at 18 communities Baoji City by multi-stage stratified random sampling. Based on data, we calculated concentration index for different income difference ages. We investigated...
Glucose transporter-1 (GLUT-1) as the major glucose transporter present in human cells is found overexpressed a proportion of malignancies. This meta-analysis attempted to assess prognostic significance GLUT-1 for survival various cancers.We conducted an electronic search using databases PubMed, Embase and Web Science, from inception Oct 20th, 2016. Pooled hazard ratios (HRs) 95% confidence intervals (CIs) were calculated.Fourty-one studies with total 4794 patients included. High expression...
Abstract Background Factor XI (FXI) deficiency is an autosomal hemorrhagic disorder characterized by reduced plasma FXI levels. Multiple ancestral variants in the F11 gene have been identified Ashkenazi Jews and other selected European populations. However, there are few reports of predominant Chinese and/or East Asian The aim this study to characterize genotypes phenotypes identify variants. Results Of 41 FXI-deficient patients, 39 exhibited severe defects, considerably more than those with...
Metabolic syndrome (MetS) and obesity are risk factors for cardiovascular disease, however, it remains unclear about effects of MetS with or without on perioperative long-term morbidity mortality after coronary artery bypass graft (CABG).An observational cohort study was performed 4,916 consecutive patients receiving isolated primary CABG in Fuwai hospital. Of all patients, 1238 met the inclusion criteria were divided into three groups: control, (n = 868, 76 294 respectively). The patient's...