Inflammasomes are reported to be abnormally expressed and activated in several malignancies play important roles tumor development. The present study was designed investigate the expression function of NLR family pyrin domain containing protein 3 (NLRP3) inflammasome oral squamous cell carcinoma (OSCC). NLRP3 OSCC lines normal human immortalized epithelial cells (HIOEC) determined by real-time PCR western blot. Immunohistochemistry used examine IL-1β paraffin-embedded tissues. proliferation...

Abstract Angiogenesis is the process by which new vessels form from existing vascular networks. Human umbilical vein endothelial cells (HUVECs) may contribute to study of repair and angiogenesis. The chemokine CXCL12 regulates multiple cell functions, including angiogenesis, mainly through its receptor CXCR4. In contrast CXCL12/CXCR4, few studies have described roles for CXCR7 in biology, downstream mechanism angiogenesis remains unclear. results present showed that dose-dependently enhanced...

ABSTRACT Aim This study aims to investigate the association of glycemia risk index (GRI), a novel composite metric derived from continuous glucose monitoring (CGM), with arterial stiffness in patients type 2 diabetes. Materials and Methods A total 342 adults diabetes were enrolled between April June 2023 11 communities Shanghai, China. Medical examinations, including measurements anthropometric parameters, blood pressure, venous samples conducted. Brachial‐ankle pulse wave velocity (baPWV)...

Tripartite motif-containing 24 (TRIM24), a member of the transcriptional intermediary factor 1 family, functions as co-regulator that positively or negatively modulates activities several nuclear receptors. The aim this study was to investigate TRIM24 expression and its clinical significance in head neck squamous cell carcinoma. levels variants were examined carcinoma (HNSCC) samples lines by real-time PCR WB. measured 91 locally advanced HNSCC tumors immunohistochemistry correlated with...

Journal Article Accepted manuscript Right coronary artery-to-left ventricular fistula with a rare giant aneurysm larger than the size of heart cavity Get access Han Fang, MD, MD 1Department Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan, Search for other works by this author on: Oxford Academic PubMed Google Scholar Li Jiang, Corresponding author: Tel: +86-18208178145, E-mail: [email protected] https://orcid.org/0000-0001-7394-9346 Zhi-Gang Yang,...

Cardiometabolic risk factors have been associated with the of late-onset dementia. However, evidence regarding early-onset dementia was inconsistent, and impact clustered cardiometabolic unclear. We aimed to investigate associations profiles incident Among 289 494 UK Biobank participants, cluster analysis built on 12 common markers. Analyses were performed those aged <65 years at baseline (n = 249 870) for ≥65 end follow-up 191 213) During a median 14.1 years, 279 cases 3167 documented. five...

Abstract Background Human papillomavirus (HPV) integration into the host genome is an important factor in HPV(+)OPSCC carcinogenesis, conjunction with HPV oncoproteins E6/E7. However, a well‐studied investigation about virus–host interaction still needs to be completed. Our objective characterise investigate potential mechanisms of tumourigenesis independent E6/E7 oncoproteins. Materials and methods High‐throughput viral detection was performed on 109 tumours relevant clinicopathological...

Background: The aim of this study was to investigate the expression apoptosis‐inhibitory Bcl‐2 protein and apoptosis‐promoting Bax identify their association with clinical parameters prognosis patients oral squamous cell carcinoma (OSCC). Methods: proteins evaluated by immunohistochemical staining in specimens from 110 OSCC. Every section scored according both percentage positive tumor cells intensity. Kaplan‐Meier test Cox proportional hazards regression analysis were performed assess...

Abstract Objective Prediabetes and lifestyle factors have been associated with the risks of multiple adverse outcomes, but effect a healthy on prediabetes‐related complications remains unknown. We aimed to investigate whether outcomes including incident type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), chronic kidney (CKD) among individuals prediabetes can be offset by broad combination factors. Methods This prospective study used data from UK Biobank cohort. An overall score...

Angiogenesis is an important pathway for revascularization of ischemic tissues after acute myocardial infarction (AMI). It unclear what role CXCR7 plays in angiogenesis the area AMI, although some researchers have shown that activation protectsthe heart under those conditions. Here, we hypothesize promotes angiogenesis, reduces cell apoptosis and alleviates cardiac deficiency AMI. C57BL/6 J mice were subjected to AMI treated with TC14012 (10 mg/kg) 24 days. HUVECs cultured a hypoxic (2% O2)...

Notch1 signaling is essential for tissue development and tumor progression. This pathway has also been implicated in oral leukoplakia (OL) squamous cell carcinoma (OSCC). However, the role of expression OL its malignant transformation unknown. study aimed to examine patterns by immunohistochemistry (IHC) a cohort 78 Chinese patients with analyze relationship between progression OSCC. Strong staining was observed 10 (13%) patients, but it not associated any clinicopathological parameters. we...

Abstract Background Ultrafiltration decreases total body water and improves the alveolar to arterial oxygen gradient. The aims of study were investigate efficacy safety early ultrafiltration in acute decompensated heart failure (ADHF) patients. Methods 100 patients with ADHF within 24 h admission randomly assigned into (n = 40) or torasemide plus tolvaptan 60) groups. primary outcomes weight loss an increase urine output on days 4 8 treatment. Results Patients who received for 3 achieved a...

Background: To determine whether intracoronary pro-urokinase or tirofiban improves myocardial reperfusion during primary percutaneous coronary intervention (PCI) for acute ST-segment elevation infarction (STEMI). Methods: The study included patients with STEMI presenting within 12 h of symptoms at 11 hospitals in China between November 2015 and July 2017. Patients were randomized to receive selective infusion recombinant (20 mg), (10 μg/kg), saline mL) proximal the infarct-related lesion...

The di-leucine motif exists in the intracellular domains of certain cell surface receptors, participating receptor-mediated endocytosis. present study was aimed at determining role class A scavenger receptor (SR-A)-mediated ligand endocytosis.cDNA coding for a mutant (SR-A N3132LM) with deletion structure transfected into Chinese hamster ovary (CHO) cells. Compared wild-type SR-A-expressing cells, cells expressing SR-A N3132LM showed significant decrease uptake but almost no change binding...

J Oral Pathol Med (2010) 39: 470–476 Background: Previously, we established an in vitro cellular carcinogenesis model of oral squamous cell carcinoma (OSCC), including the human immortalized epithelia cells (HIOECs) and its derived cancerous HB cells. Then, expression microarray analysis showed that gene encoding fos-related activator-1 (Fra-1) was significantly upregulated compared with HIOECs. Methods: To confirm Fra-1 at mRNA protein levels by real-time PCR western blotting OSCC CAL27...

Purpose To find the potential biomarkers in diagnostic model of oral and squamous cell carcinoma (OSCC), to further validate biomarker. Experimental design With MALDI–TOF–MS analysis between tissues from cancer patients normal mucosa healthy controls, scavenger receptor class A member 5 (scara5) is found be potentially significant after searching protein database. In addition, Immunohistochemical staining, PCR, ELISA, Western blot technique are used detect scara5 expression clinical samples...

// Wei Cao 1, 2, * , Jiannan Liu Ronghui Xia 3 Lu Lin 4 Xu Wang 2 Meng Xiao Chenping Zhang Jiang Li Tong Ji Wantao Chen 1 Department of Oral Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, Shanghai Jiao University School Medicine, 200011, China Research Institute Stomatology Key Laboratory Stomatology, Pathology, Medical Records, These authors contributed to this work equally Correspondence to: Chen, e-mail: chenwantao196323@sjtu.edu.cn Ji, jitong70@hotmail.com Keywords: head...

Platelet-derived growth factors alpha (PDGFA) is a tyrosine kinase receptor activator which known to be amplified in the malignancies, and their expression levels are correlated tumor progression reduced overall survival. The of PDGFRA different among tumors normal tissues; furthermore, level site specific. Under physiological condition, its ligand expressed distinct cell populations activated paracrine manner. Nevertheless, heterodimer characteristic allows it trans-activated by...

Abstract Aim To explore the relationship between proinflammatory diet, habitual salt intake and onset of type 2 diabetes. Methods This prospective study was conducted among 171 094 UK Biobank participants who completed at least one 24‐h dietary questionnaire were free diabetes baseline. Participants followed up until 1 March 2023 for incidence, with diagnosis information obtained from linked medical records. An Energy‐adjusted Diet Inflammatory Index (E‐DII) calculated based on 28 food...