A5101807183- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Atherosclerosis and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Immune cells in cancer
- Cardiovascular Function and Risk Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac tumors and thrombi
- Cell Adhesion Molecules Research
- Inflammatory mediators and NSAID effects
- Cardiac Ischemia and Reperfusion
- Immune Response and Inflammation
- Heart Failure Treatment and Management
- Inflammasome and immune disorders
- Atrial Fibrillation Management and Outcomes
- Cholesterol and Lipid Metabolism
- Protein Degradation and Inhibitors
- Autophagy in Disease and Therapy
- Histone Deacetylase Inhibitors Research
- Cardiac and Coronary Surgery Techniques
- Adenosine and Purinergic Signaling
- Advanced Glycation End Products research
- Traditional Chinese Medicine Analysis
- Advanced MRI Techniques and Applications
Fudan University
2014-2024
Zhongshan Hospital
2014-2024
Shanghai Sixth People's Hospital
2024
Shanghai Jiao Tong University
2024
The First Affiliated Hospital, Sun Yat-sen University
2013-2023
Sun Yat-sen University
2013-2023
Shanghai Clinical Research Center
2023
Shanghai Institute of Hematology
2020
Second Military Medical University
2005
Abstract Whether dendritic cell ( DC ) derived exosomes play a role in the progression of endothelial inflammation and atherosclerosis remains unclear. Using transwell system exosome release inhibitor GW 4869, we demonstrated that mature s contributed to were involved process. To further confirm this finding, isolated from bone marrow BMDC culture medium (named ‐exos) stimulated human umbilical vein HUVEC with these ‐exos. We observed ‐exos increased through NF ‐κB pathway manner similar...
Both advanced glycosylation end products (AGEs) and dendritic cells (DCs) have been shown to play a causative role in atherosclerosis. However, whether they function interactively the process remains uncertain. We therefore studied effects of AGE-bovine serum albumin (AGE-BSA) on maturation DCs expressions scavenger receptor-A (SR-A) receptor for AGEs (RAGE) DCs.AGE-BSA induced accompanied with increased CD1a, CD40, CD80, CD83, CD86, MHC class II. The capacity stimulate T-cell proliferation...
Abstract Background Both hyperglycaemia and dendritic cells (DCs) play causative roles in atherosclerosis. However, whether they interact atherosclerosis remains uncertain. Therefore, we examined high glucose could regulate the expression of scavenger receptors responsible for oxidised low-density lipoprotein (oxLDL) uptake DCs, a critical step atherogenesis. In addition, investigated impact on DC maturation regarding changes phenotype cytokine secretion. Methods Immature DCs were cultured...
SIRT6, an important NAD+ -dependent protein, protects endothelial cells from inflammatory and oxidative stress injuries. However, the role of SIRT6 in cardiac microvascular (CMECs) under ischemia-reperfusion injury (IRI) remains unclear.The HUVECs model oxygen-glucose deprivation/reperfusion (OGD/R) was established to simulate IRI vitro. Endoplasmic reticulum oxidase 1 alpha (Ero1α) mRNA protein levels SIRT6-overexpressing or SIRT6-knockdown were measured by qPCR Western blotting. The H2 O2...
Background: To determine whether intracoronary pro-urokinase or tirofiban improves myocardial reperfusion during primary percutaneous coronary intervention (PCI) for acute ST-segment elevation infarction (STEMI). Methods: The study included patients with STEMI presenting within 12 h of symptoms at 11 hospitals in China between November 2015 and July 2017. Patients were randomized to receive selective infusion recombinant (20 mg), (10 μg/kg), saline mL) proximal the infarct-related lesion...
Background Atherosclerosis (AS) risk is elevated in diabetic patients, but the underlying mechanism such as involvement of epigenetic control foam macrophages remains unclear. We have previously shown importance immune regulation on endothelial cells to AS development diabetes. In this study, we examined hypothesis that diabetes may promote through modification status macrophages. Methods employed Laser Capture Microdissection (LCM) method evaluate expression levels key regulators both and...
We aimed to investigate short-term outcomes of the XINSORB bioresorbable sirolimus-eluting scaffold in human coronary artery.Bioresorbable scaffolds are considered be fourth milestone percutaneous intervention.Thirty patients with symptomatic ischemic disease were enrolled and treated that 3.0 × 12, 15, 18 mm size. The primary angiographic endpoint was late luminal loss (LLL), whereas clinical major adverse cardiac events (MACEs) at 6 month follow-up. In a subset 19 patients, intravascular...
Inflammatory damage to endothelial cells plays a pivotal role in the diabetes-provoked atherosclerosis (AS). PYD domains-containing protein 3 (NLRP3) induces formation of inflammasome activates caspase-1, which subsequently cleaves precursor form IL-1β (pro-IL-1β) into processed, secreted promote immune responses AS. However, it is not known whether NLRP3 activation specifically causes Here, an vitro model for AS, we showed that NLRP3-depleted human aortic (HAECs) became resistant apoptotic...
Background The peroxisome proliferator-activated receptor (PPAR) activation has generally been shown to have anti-inflammatory effects and dendritic cells (DCs) are the most efficient antigen presenting that play an active role in development of atherosclerosis. PPARγ on DCs maturation immune function remain unknown now we, therefore, studied influence agonist ciglitazone DCs. Methods Human monocytes were purified immature derived; (25 μmol/L) was added medium for 24 hours; ox-LDL (50 μg/ml)...
The angiotensin II receptor-1 blockers have generally been shown to antiatherogenic effects, and dendritic cells (DCs) are the most efficient antigen presenting that play an active role in development of atherosclerosis through inflammatory-immune responses. Here, we tested hypothesis effect losartan, first blockers, might partly be mediated by attenuating DCs maturation. In this study, showed oxidized low-density lipoprotein (oxLDL) (Ang II) could induce maturation human monocyte-derived...
Angiography-derived fractional flow reserve (FFR) (angio-FFR) has been validated against FFR and could provide virtual pullback. However, whether a physiological map can be generated by angio-FFR its clinical value remains unclear. We aimed to investigate the feasibility of created from pullback in predicting outcomes after stenting.An was overlaying onto coronary angiogram, calculate stenosis severity, length, intensity (Δangio-FFR/mm). This combination with stenting used predict best-case...
Premature coronary artery disease (PCAD) is increasingly common in Asian countries; however, less known regarding its characteristics and clinical outcomes. This study aims to describe investigate outcomes real-world patients with PCAD.A total of 4700 undergoing drug-eluting stent implantation were included our divided into PCAD group mature CAD (MCAD) according their onset age. All followed up for 3 years observe outcomes.Patients more likely be associated acute syndrome (ACS; P = .03)...
Dendritic cells (DCs) play a crucial role as central orchestrators of immune system response in atherosclerosis initiation and progression. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is involved the maturation DCs, but underlying mechanisms remain unclear. We isolated mouse bone marrow progenitors stimulated them with granulocyte-macrophage colony-stimulating factor interleukin (IL)-4 to induce immature DCs. then treated DCs (oxLDL) maturation. LOX-1 siRNA was used...
Abstract Background The predictors of success chronic total occlusion (CTO) percutaneous coronary intervention (PCI) through antegrade dissection and re‐entry (ADR) using the Stingray system (Stingray ADR) remain elusive, mainly owing to lack consecutive angiographic procedural records patients. Objectives This study aimed identify indicators that can determine CTO PCI performed ADR technique. Methods clinical data 115 patients who underwent at same cardiac center were retrospectively...
Introduction . Although coronary artery disease (CAD) presentations and clinical outcomes differ by sex, little is known about premature CAD (PCAD). The present analysis aimed to evaluate the gender-related differences of PCAD in an Asian population from FOCUS registry. Methods A total 1397 young patients with angiographically confirmed undergoing drug-eluting stent implantation were included this divided into two groups according genders. Patients followed up for three years compared...
Thrombus embolization and microvascular obstruction during percutaneous coronary intervention (PCI) in ST-segment elevation myocardial infarction (STEMI) is commonly detected, which causes inadequate perfusion elevated infarct size. An approach with low-dose intracoronary fibrinolytic treatment for reducing distal improving reperfusion high-risk STEMI cases remains controversial.The RECOVER II study represents a multicenter, randomized, double-blind, parallel-group trial assessing adjunctive...
Objective. The initial recanalization rate of coronary chronic total occlusions (CTOs) is >85% when performed by experienced operators, but only 10% prior failed CTO patients receive reattempted recanalization. This retrospective study analyzed the success and strategies used in reattempt percutaneous intervention (PCI) CTOs after failures. Methods. Overall, 206 with 212 were enrolled. All failures received PCIs from January 2015 to March 2019 at Zhongshan Hospital, Fudan University. Data...