A5101817164- Dental Health and Care Utilization
- Breast Cancer Treatment Studies
- Dental Erosion and Treatment
- Oral microbiology and periodontitis research
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Cervical Cancer and HPV Research
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Sirtuins and Resveratrol in Medicine
- Meteorological Phenomena and Simulations
- Atmospheric Ozone and Climate
- RNA Research and Splicing
- Breast Lesions and Carcinomas
- Cancer Genomics and Diagnostics
- Multiple Myeloma Research and Treatments
- Health disparities and outcomes
- Climate variability and models
- Autophagy in Disease and Therapy
- Molecular Biology Techniques and Applications
- Mitochondrial Function and Pathology
- Breast Implant and Reconstruction
- Advanced Breast Cancer Therapies
- Biological and pharmacological studies of plants
Zhongshan Hospital
2022-2024
Guangxi Medical University
2019-2024
The First Affiliated Hospital, Sun Yat-sen University
2023-2024
Fudan University
2022-2024
Sun Yat-sen University
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Stomatology Hospital
2023-2024
Ningxia Medical University
2023-2024
Nanjing University of Information Science and Technology
2023-2024
China International Science and Technology Cooperation
2023
Abstract Rationale Lung cancer is the most prevalent form of and has a high mortality rate, making it global public health concern. The N 6 -methyladenosine (m A) modification highly dynamic reversible process that involved in variety essential biological processes. Using vitro, vivo, multi-omics bioinformatics, present study aims to determine function regulatory mechanisms long non-coding (lnc)RNA zinc ribbon domain-containing 1-antisense 1 (ZNRD1-AS1). Methods RNAs were bound m A ‘reader’...
Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is one of the most prominent housekeeping proteins and widely used as an internal control in some semi-quantitative assays. In addition to glycolysis, GAPDH involved several cancer-related biological processes has been reported be commonly dysregulated multiple cancer types. Therefore, its role physiological process needs urgently elucidated. Pan-cancer analysis indicated that ubiquitously highly expressed types, patients with a high...
SIRT6, an important NAD+ -dependent protein, protects endothelial cells from inflammatory and oxidative stress injuries. However, the role of SIRT6 in cardiac microvascular (CMECs) under ischemia-reperfusion injury (IRI) remains unclear.The HUVECs model oxygen-glucose deprivation/reperfusion (OGD/R) was established to simulate IRI vitro. Endoplasmic reticulum oxidase 1 alpha (Ero1α) mRNA protein levels SIRT6-overexpressing or SIRT6-knockdown were measured by qPCR Western blotting. The H2 O2...
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by abnormal activation of CD4
Lung cancer is one of the most common types carcinoma worldwide.Cigarette smoking considered leading cause lung cancer.Aberrant expression several YT521-B homology (YTH) family proteins has been reported to be closely associated with multiple types.The present study aims evaluate function and regulatory mechanisms N6-methyladenosine (m 6 A) reader protein YTH domain containing 2 (YTHDC2) by in vitro, vivo bioinformatics analyses.The results revealed that YTHDC2 was reduced cigarette...
Socioeconomic inequalities in oral health are often neglected promotion. This cross-sectional study assessed the association between dental caries and socioeconomic status (SES) among preschool children China.Cross-sectional study.Data from Fourth National Oral Health Survey of China (2015), comprising 40 360 aged 3-5 years was used.Dental indicators including prevalence caries, pain experience number decayed, missing filling teeth (dmft). SES included parental education household income....
The objectives of this study were to evaluate the cost-effectiveness and cost-benefit fluoride varnish (FV) interventions for preventing caries in first permanent molars (FPMs) among children rural areas Guangxi, China.
: Heart failure with preserved ejection fraction (HFpEF) is a predominant type of heart failure. Exploring new pathogenesis and identifying potential novel therapeutic targets for HFpEF paramount importance.
•Partial endothelial-to-mesenchymal transition (EndMT) helps create new blood vessels and repair tissues after a lack of flow.•GTF2H4 works together with ERCC3 to encourage partial EndMT through the NCOA3/NF-κB/Snail pathway.•Targeting endothelial GTF2H4 could be hopeful treatment for diseases caused by insufficient supply. Partial is an intermediate phenotype observed in cells (ECs) undergoing toward mesenchymal state support neovascularization during (patho)physiological angiogenesis....
Breast cancer ( BC ) is an aggressive malignant disease in women worldwide with a high tendency to metastasize. However, important biomarkers for metastasis remain largely undefined. In the present study, we identified that long non‐coding RNA ‐ CTD ‐2108O9.1 downregulated tissues and cells acts as metastatic inhibitor of . Mechanistic investigation determined lnc represses by targeting leukemia inhibitory factor receptor LIFR ), which designated suppressor Our study characterizes...
Administration of anthracycline-based chemotherapy with or without trastuzumab is recognized as standard care for breast cancer, but it associated a decline in left ventricular ejection fraction (LVEF). Angiotensin-converting enzyme inhibitors (ACEI)/angiotensin II receptor blockers (ARB) might decrease this cardiac dysfunction caused by the anti-cancer therapy. We sought to evaluate prophylactic effects cardioprotective agents ACEI/ARB early-stage cancer.We systematically searched...
Angiogenesis is associated with tumour growth, infiltration, and metastasis. This study aimed to detect the mechanisms of angiogenesis-related genes (ARGs) in multiple myeloma (MM) construct a new prognostic model. MM research foundation (MMRF)-CoMMpass cohort, GSE47552, GSE57317, ARGs were sourced from public databases. Differentially expressed (DEGs) control cohorts GSE47552 determined through differential expression analysis enriched Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes...
Stratospheric processes and their role in weather climate have attracted increasing interests. The correspondence between the occurrence of pulse-like, stronger stratospheric poleward warm airmass transport (PULSE) events continental-scale cold air outbreak (CAO) northern hemispheric winter is found to be unstable from year year. This increases difficulties utilizing more predictable variability sub-seasonal forecasts CAOs, which can cause hazards. Using ERA5 reanalysis data covering 37...
Abstract A Stratospheric Northern Annular Mode (SNAM) phase-based composite analysis reveals that continental Cold Air Outbreaks (CAOs) can occur during both positive and negative SNAM events. CAOs tend to over Asia, characterized by a meridional-dipole surface temperature anomaly pattern (cold midlatitudes warm high-latitudes) when the index is decreasing or stratospheric polar vortex weakening, but North America Europe with meridionally-homogeneous increasing strengthening. While dominated...