A5069591025- Acute Myeloid Leukemia Research
- Multiple Myeloma Research and Treatments
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Metal Alloys Wear and Properties
- CAR-T cell therapy research
- MicroRNA in disease regulation
- Lymphoma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Hematological disorders and diagnostics
- Retinoids in leukemia and cellular processes
- Mechanical stress and fatigue analysis
- Histiocytic Disorders and Treatments
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Tumors and Oncological Cases
- Parvovirus B19 Infection Studies
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Retinal and Macular Surgery
- Curcumin's Biomedical Applications
- Bioactive Compounds and Antitumor Agents
- Genomics, phytochemicals, and oxidative stress
- Protein Interaction Studies and Fluorescence Analysis
- Ferroptosis and cancer prognosis
First People's Hospital of Yunnan Province
2015-2024
Kunming University of Science and Technology
2020-2024
Chinese Academy of Sciences
2023-2024
Yunnan Center for Disease Control And Prevention
2023
Abstract Cytoplasmic lncRNAs have been found to directly interact with target mRNAs and regulate their stability. In this study, we aimed study the molecular mechanism underlying function of m 6 A as a central regulator in chemoresistance CML proliferation. established three mice groups (control group, ADR‐R group + shLINC00470 group). We detected PTEN mRNA expression presence LINC00470 models, well KCL22 K562 cells. was significantly enriched for exhibit negative regulatory relationship...
We investigated the association between polymorphisms in interleukin-10 (IL-10) -1082G/A (rs1800896), -819T/C (rs1800871), and -592A/C (rs1800872) risk of acute myeloid leukemia (AML) a Chinese population.A total 167 primary AML cases 328 healthy control subjects were recruited at First People's Hospital Yunnan Province March 2009 January 2012.The rs1800896, rs1800871, rs1800872 genotyped by polymerase chain reaction-restriction fragment length polymorphism.Multivariate regression analyses...
To investigate the clinicopathological features, and mutations of NRAS, KRAS, BRAF MAP2K1 genes in extranodal Rosai-Dorfman disease (RDD).The clinic opathological features 27 patients with RDD were retrospectively analyzed, mutation detected by Sanger sequencing.The male to female ratio was 1.7:1. The average age 46.9 years. There skin lesions 12 cases (44.4%) head neck 8 (29.6%). Microscopically, those had characterized clear dark intervals obvious emperipolesis, while other parts,...
Angiogenesis is associated with tumour growth, infiltration, and metastasis. This study aimed to detect the mechanisms of angiogenesis-related genes (ARGs) in multiple myeloma (MM) construct a new prognostic model. MM research foundation (MMRF)-CoMMpass cohort, GSE47552, GSE57317, ARGs were sourced from public databases. Differentially expressed (DEGs) control cohorts GSE47552 determined through differential expression analysis enriched Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes...
The Functional Assessment of Cancer Therapy–Leukemia (FACT-Leu) scale, a leukemia-specific instrument for determining the health-related quality life (HRQOL) in patients with leukemia, had been developed and validated, but there have no reports on development simplified Chinese version this scale. This is new exploration to analyze reliability HRQOL measurement using multivariate generalizability theory (MGT). study aimed develop FACT-Leu scale evaluate its MGT provide evidence support...
BACKGROUND:Immunotherapy has been explored as a new therapy for B cell lymphoma, which is non-Hodgkin's lymphoma. Because CD20 lymphocyte-specific marker, anti-CD20 single chain-tagged T lymphocytes have already begun to be experimentally used in lymphoma treatment, but its use still limited because of unspecific targeting. cells transfected with CD28 and CD137 can significantly improve the ability cytokines secretion anti-tumor effect, well extending survival time improving their...
Multiple myeloma (MM) is an incurable cancer that characterized by malignant plasma cell proliferation. Approximately 10% of all blood cancers are MM, and there no standard curative therapy. In this work, we intended to synthesize, characterize, assess the anticancer effects selenium/chitosan/polyethylene glycol-carvacrol nanocomposites (SCP-Car-NCs) on MM U266 cells in vitro. Various characterization techniques were used characterize synthesized SCP-Car-NCs. Several vitro free radical...
Hyperleukocytic acute leukemia (HLAL) circulating exosomes are delivered to hematopoietic stem cells (HSCs) and bone marrow mesenchymal (BM-MSCs), thereby inhibiting the normal process. In this paper, we have evaluated explored effects of miR-125b, which is carried by HLAL-derived exosomes, on function HSCs BM-MSCs. For purpose, isolated from peripheral blood HLAL patients healthy volunteers. Then, measured level miR-125b in cocultured with Moreover, used inhibitors/mimic for intervention...
The immune system plays a pivotal role in defending against infection and cancer immunosurveillance during the onset procession of malignant disease. Cancer patients are frequently immunocompromised subject to refractory relapse leukemia, due cytotoxic agents immunosuppressive glucocorticoids chemotherapy regimens. Bu Shen Hui Yang Fang (BSHY), traditional Chinese compound, was widely used China enhance leukemia combined with effectively lowered their risk infection, specific mechanism...
Cancer is the world's biggest health problem and cancer-induced mortality happened all over planet after heart disease. The present study was to scrutinize anti-leukemia effect of diosmin against Dalton Ascitic Lymphoma (DAL) induced leukemia in mice. DAL cell used for induction solid tumor. Body weight, life spans, tumor volume mean survival time estimated. Antioxidant, biochemical pro-inflammatory cytokines were Diosmin showed viability at dose dependent manner both lines. mice decreased...
Cancer is still remain as a global burden with the 18.1 million and 9.6 new cases mortlities, respectively estimated globally. Leukemia may arise at all ages varied from infants to elders. In this exploration, we planned evaluate antiproliferative effect of D-pinitol on human leukemia MOLT-4 cells. Anticancer potential was examined using MTT assay. Reactive oxygen species (ROS) generation studied by fluorescence microscopic method DCFH-DA staining. Apoptotic morphological alterations were...
Leukemia is a hematological malignancy characterized by the proliferation of early lymphoid precursors that replaces normal hematopoietic cells bone marrow. Nakhi (Naxi) ethnic minorities considered to be an area low incidence. MicroRNAs (miRNAs) are class small noncoding RNAs regulate expression other genes in various biological processes. The purpose this work study molecular mechanism miRNAs leukemia from Naxi.Six patients (case 2 case 7) and one healthy person 1) were recruited. Total...
To propose a time‐saving method for evaluating the fatigue strength of carburized steel, behavior and fracture mechanism 14Cr14Co13Mo5 steels are studied by rotary bending tests. It is found that crack initiation site changes from surface to internal after carburizing due residual compressive stress carbide cluster caused carburization. Besides, notable correlation between intensity cracked carbides at life observed in samples. This allows estimation long conditional based on samples tested...
Background: Leukemia is known to be a common type of cancer mostly affecting children. The standard therapeutic treatment available for leukemia has many drawbacks with serious side effects. Therefore, plant-based chemotherapeutic agents that show less/no toxic effects might an efficient way treat leukemia. in this study, we aimed explore the potential β-caryophyllene, obtained from various plants sources, and found it persuades oxidative stress-associated apoptosis during repression...
Introduction: Pyoderma gangrenosum (PG) is a rare noninfectious neutrophilic skin disease. The diagnosis of PG mainly based on clinical manifestations. Therefore, the features are important for confirming this Herein, data 2 young males with complicated hematological malignancies were reported, and literature reviewed. Case presentation: first case was 22-year-old male who admitted due to systemic rash, headache, fever. Physical examination showed black scabs skins extremities, trunk, scalp,...