A5100743983- Microbial Natural Products and Biosynthesis
- Corneal Surgery and Treatments
- Connexins and lens biology
- Marine Sponges and Natural Products
- Fungal Biology and Applications
- Intraocular Surgery and Lenses
- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- Optical Coherence Tomography Applications
- Microbial Metabolism and Applications
- Non-Invasive Vital Sign Monitoring
- Hip and Femur Fractures
- Retinal and Macular Surgery
- Chemical synthesis and alkaloids
- Bone fractures and treatments
- Heart Rate Variability and Autonomic Control
- Treatment of Major Depression
- Fatigue and fracture mechanics
- Gastroesophageal reflux and treatments
- Refrigeration and Air Conditioning Technologies
- Gastrointestinal motility and disorders
- Antimicrobial Peptides and Activities
- Microstructure and Mechanical Properties of Steels
- Orthopaedic implants and arthroplasty
- Retinal Diseases and Treatments
Chinese Academy of Sciences
2019-2024
Miami University
2020-2024
South China Sea Institute Of Oceanology
2019-2023
Institute of Oceanology
2019-2023
Karolinska Institutet
2023
TU Dresden
2023
The First People's Hospital of Zhaoqing
2023
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2022
University of Chinese Academy of Sciences
2019-2021
Ming Chuan University
2016
Five undescribed butenolides including two pairs of enantiomers, (+)-asperteretal G (1a), (-)-asperteretal (1b), H (2a), (2b), asperteretal I (3), and para-hydroxybenzaldehyde derivative, (S)-3-(2,3-dihydroxy-3-methylbutyl)-4-hydroxybenzaldehyde (14), were isolated together with ten previously reported 4-13, from the coral-derived fungus Aspergillus terreus SCSIO41404. Enantiomers 1a/1b 2a/2b successfully purified by high performance liquid chromatography (HPLC) using a chiral column,...
Two new polyketides, xerucitrinin A (1) and coniochaetone M (8), one steroid, 16α-methylpregna-17α,19-dihydroxy-(9,11)-epoxy-4-ene-3,18-dione-20-acetoxy (13), together with eleven known analogues were isolated from fungus Penicillium citrinum SCSIO 41017 associated the sponge Callyspongia sp. Their structures absolute configurations elucidated by NMR spectra, MS, CD, optical rotation, X-ray crystallography, compared literature data. Biological evaluation results revealed that 5 exhibited...
Abstract Background Previous studies have suggested that macrophages are present during lens regeneration in newts, but their role the process is yet to be elucidated. Methods Here we generated a transgenic reporter line using newt, Pleurodeles waltl , traces regeneration. Furthermore, assessed early changes gene expression two newt species, Notophthalmus viridescens and . Finally, used clodronate liposomes deplete both species tested effect of subsequent secondary injury after macrophage...
Guided by Global Natural Products Social molecular networking, two p-terphenyl derivatives and one 4,5-diphenyl-2-pyrone analogue, peniterphenyls A–C (1–3), together with five known (4–8) sulochrin (9), were obtained from a deep-sea-derived Penicillium sp. SCSIO41030. Their structures elucidated using extensive NMR spectroscopic HRESIMS data comparing the information literature data. Peniterphenyl B (2) represented first reported natural product possessing 4,5-diphenyl-substituted 2-pyrone...
Iakyricidins A-D (1-4), a carbonyl-containing piericidin derivative and three novel analogues bearing cyclic skeletons, were isolated from the mangrove sediment derived strain Streptomyces iakyrus SCSIO NS104. These structures established by spectroscopic techniques, Mosher's method, ECD calculations. Compounds 2-4 represent skeleton of piericidins with branched chain C-C cyclization, their biosynthetic pathways are proposed. Compound 1, first natural derivate, exhibited potent...
Main observation and conclusion Four new polyketide decalin derivatives, penicisteck acids A—D (1—4), three nitrogenous compounds (7—9), together with eight previously reported compounds, were isolated from the mangrove endophytic fungus Penicillium steckii SCSIO 41025. Their structures absolute configurations characterized by analysis of comprehensive spectroscopic data combined ECD calculations modified Marfey's method. Structurally, 1—3 highly oxygenated derivatives harboring an unusual...
Purpose: To establish optical coherence tomography (OCT) as an in vivo imaging modality for investigating the process of newt lens regeneration. Methods: Spectral-domain OCT was employed regeneration process. A total 37 newts were lentectomized and followed by over course 60 to 80 days. Histological images obtained at several time points compare with corresponding images. Volume measurements also acquired. Results: can identify key features observed histological based on scattering...
Ten polyketide derivatives (1–10), including a new natural product named (E)-2,4-dihydroxy-3-methyl-6-(2-oxopent-3-en-1-yl) benzaldehyde (1), and five known diketopiperazines (11–15), were isolated from the mangrove-sediment-derived fungus Aspergillus sp. SCSIO41407. The structures of 1–15 determined via NMR MS spectroscopic analysis. In variety bioactivity screening, 3 showed weak cytotoxicity against A549 cell line, 2 exhibited antibacterial activity methicillin-resistant Staphylococcus...
Aging and regeneration are heavily linked processes. While it is generally accepted that regenerative capacity declines with age, some vertebrates, such as newts, can bypass the deleterious effects of aging successfully regenerate a lens throughout their lifetime. Here, we used Spectral-Domain Optical Coherence Tomography (SD-OCT) to monitor process larvae, juvenile, adult newts. all three life stages were able through transdifferentiation dorsal iris pigment epithelial cells (iPECs), an...
Five new fusarin derivatives, steckfusarins A–E (1–5), and two known natural products (6, 7), were isolated identified from the marine algicolous fungus Penicillium steckii SCSIO 41040. The compounds, including absolute configurations, determined by spectroscopic analyses calculated electronic circular dichroism (ECD). All compounds evaluated for their antioxidant, antibacterial, antifungal, antiviral, cytotoxic, anti-inflammatory, cholesterol-lowering, acetyl cholinesterase (AChE) enzyme...
Twelve indole alkaloids, including α-cyclopiazonic acid (CPA) (1), nine 2-oxo CPA derivatives (2-10), and two open-ring (11 12), were isolated from the fermentation broth of a deep-sea derived fungus Aspergillus sp. SCSIO 41024. Their structures absolute configurations elucidated mainly by using extensive NMR spectroscopic, mass spectrometric single crystal X-ray diffraction analysis. To best our knowledge, crystallographic data 3 7 firstly reported, configuration was confirmed for first...
Three novel cyclic hexapeptides, sclerotides C-E (
Abstract Previous studies indicated that macrophages play a role during lens regeneration in newts, but their function has not been tested experimentally. Here we generated transgenic newt reporter line which can be visualized vivo . Using this new tool, analyzed the location of regeneration. We uncovered early gene expression changes using bulk RNAseq two species, Notophthalmus viridescens and Pleurodeles waltl Next, used clodronate liposomes to deplete macrophages, inhibited both species....
The aim of this study was to validate the advantages intrafascial nerve-sparing technique compared with interfascial in extraperitoneal laparoscopic radical prostatectomy.From March 2010 August 2011, 65 patients localized prostate cancer (PCa) underwent bilateral prostatectomy.These were matched a 1 : 2 ratio 130 PCa who had undergone prostatectomy between January 2008 and 2011.Operative data oncological functional results both groups compared.There no difference operative data, pathological...
A new indole diketopiperazine alkaloid, named penilline D (1), together with five known alkaloid analogues (2-5, 11), two meroterpenoids (6 and 12), four butenolide derivatives (7-10), were isolated from the Antarctic fungus Penicillium sp. SCSIO 05705. Extensive spectroscopic analysis electronic circular dichroism (ECD) calculation used to elucidate structure of including its absolute configuration. All compounds (1-12) evaluated for their cytotoxic, antibacterial enzyme inhibitory...
To propose a time‐saving method for evaluating the fatigue strength of carburized steel, behavior and fracture mechanism 14Cr14Co13Mo5 steels are studied by rotary bending tests. It is found that crack initiation site changes from surface to internal after carburizing due residual compressive stress carbide cluster caused carburization. Besides, notable correlation between intensity cracked carbides at life observed in samples. This allows estimation long conditional based on samples tested...