A5005219405- Bone Metabolism and Diseases
- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Antimicrobial agents and applications
- Metal complexes synthesis and properties
- Fungal Biology and Applications
- NF-κB Signaling Pathways
- Bone health and treatments
- Bacterial biofilms and quorum sensing
- Natural product bioactivities and synthesis
- Antimicrobial Peptides and Activities
- Immune cells in cancer
- Natural Compounds in Disease Treatment
- Cell Adhesion Molecules Research
- Orthopedic Infections and Treatments
- Immune Cell Function and Interaction
- Advanced biosensing and bioanalysis techniques
- Chemical synthesis and alkaloids
- Click Chemistry and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Signaling Pathways in Disease
- Ferrocene Chemistry and Applications
- Phagocytosis and Immune Regulation
South China Agricultural University
2025
Guangxi Normal University
2019-2024
Southern Medical University
2018-2022
Yantai University
2019
South China Sea Institute Of Oceanology
2018
Institute of Oceanology
2018
Chinese Academy of Sciences
2018
To discover novel osteoclast-targeting antiosteoporosis leads from natural products, we identified 40 tanzawaic acid derivatives, including 22 new ones (1–8, 14–19, 27–32, 37, and 38), the South China Sea mangrove-derived fungus Penicillium steckii SCSIO 41025. Penicisteck F (2), one of derivatives showing most potent NF-κB inhibitory activity, remarkably inhibited osteoclast generation in vitro. Mechanistically, 2 reduced RANKL-induced IκBα degradation, p65 nuclear translocation, activation...
Nitrobenzoyl sesquiterpenoids are rare from natural sources. Two new nitrobenzoyl sesquiterpenoids, insulicolide B (1) and C (3), the product 14-O-acetylinsulicolide A (2) were isolated culture extracts of marine-derived fungus Aspergillus ochraceus Jcma1F17, together with three known (4–6) a derivative sesquiterpenoid (7). The structures compounds, including their absolute configurations, determined by NMR MS spectroscopic data analyses comparison between calculated experimental ECD...
One new depsidone derivative, aspergillusidone H (3), along with seven known biosynthetically related chlorinated polyketides, were obtained from the Beibu Gulf coral-derived fungus Aspergillus unguis GXIMD 02505. Their structures determined by comprehensive physicochemical and spectroscopic data interpretation. Notably, X-ray crystal structure of 2 previously unknown absolute configuration 8, assigned ECD calculations, are described here for first time. Compounds 1–5, 7 8 exhibited...
Breast cancer-related bone metastasis can lead to skeletal-related events (SREs), which decrease patient quality of life. Inhibition osteoclastogenesis is a key treatment for SREs; however, the availability clinical drugs remains limited, and all existing ones disrupt physiological formation, while exhibiting no effect on survival time. This study aimed identify novel osteoclast inhibitor breast cancer-induced SREs. The MDA-MB-231 cancer cell-induced loss model was used investigate...
An unprecedented di-seco-indole diterpenoid, peniditerpenoid A (1), and a rare N-oxide-containing indole diterpenoid derivative, B (2), together with three known ones (3–5), were obtained from the mangrove-sediment-derived fungus Penicillium sp. SCSIO 41411. Their structures determined by analysis of spectroscopic data, quantum chemical calculations, X-ray diffraction analyses. Peniditerpenoid (1) inhibited lipopolysaccharide-induced NF-κB an IC50 value 11 μM further effectively prevented...
Kadsura coccinea is a traditional Chinese medicine whose roots have long been used to treat various ailments, but little known about the efficacy of its leaves. In this study, antidiabetic activity K. leaf extract (KCLE) was determined, main components KCLE were identified using UPLC-TOF-MS, and network pharmacology molecular docking integrated elucidate mechanism KCLE. The results showed that effectively increased glucose consumption IR-HepG2 cells through pyruvate kinase (PK) hexokinase...
Osteoclasts are unique cells to absorb bone. Targeting osteoclast differentiation is a therapeutic strategy for osteolytic diseases. Natural marine products have already become important sources of new drugs. The naturally occurring nitrobenzoyl sesquiterpenoids first identified from fungi in 1998 bioactive compounds with special structure, but their pharmacological functions largely unknown. Here, we investigated six fungus-derived on osteoclastogenesis and elucidated the...
Seven new tanzawaic acid derivatives, steckwaic acids E–K (1–7), and one benzene derivate (8), together with seven known analogues (9–16) were isolated from the marine algicolous fungus Penicillium steckii SCSIO 41040. The structures absolute configurations of these compounds (1–8) determined by spectroscopic analyses, X-ray diffraction, comparison ECD spectra to calculations. Compounds 2, 10, 15 inhibited lipopolysaccharide (LPS)-induced nuclear factor kappa-B (NF-κB) IC50 values 10.4,...
The surge of antibiotic resistance in Staphylococcus aureus calls for novel drugs that attack new targets. Developing antimicrobial peptides (AMPs) or antivirulence agents (AvAs) is a promising strategy to tackle this challenge. However, AMPs, which kill bacteria by disrupting cell membranes, suffer from low stability and high synthesis cost, while AvAs, inhibit toxin secretion, have relatively poor bactericidal activity. Here, address their respective shortcomings, we combined these two...
Abstract Latexin (LXN) is abundant in macrophages and plays critical roles inflammation. Much known about atherosclerosis, the role of macrophage LXN atherosclerosis has remained elusive. Here, expression human mouse atherosclerotic lesions was examined by immunofluorescence immunohistochemistry. knockout LXN/ApoE double-knockout mice were generated to evaluate functions atherosclerosis. Bone marrow transplantation (BMT) experimentation carried out determine whether regulates We found that...
Abstract Obesity is a risk factor for many chronic diseases, and associated with increased incidence rate of type 2 diabetes, hypertension, dyslipidemia cardiovascular diseases. Adipocyte differentiation play critical role during development obesity. Latexin (LXN), mammalian carboxypeptidase inhibitor, plays important in the proliferation stem cells, highlights as differentiation-associated gene that was significantly downregulated prostate cells whose expression increases through...
A new trithiodiketopiperazine derivative, adametizine C (1), and five alkane derivatives (7-11), were isolated from the mangrove sediment-derived fungus Penicillium ludwigii SCSIO 41408, together with known dithiodiketopiperazine (2-6). Their structures elucidated on basis of spectroscopic analysis, absolute configuration 1 was determined by X-ray crystallographic analysis. In a variety bioactivity screening, 1-5 exhibited some selective antifungal or antibacterial activities. Compounds 1-3...
Ruthenium complex <bold>Ru(II)-3</bold> functionalized with benzothiophene showed good antimicrobial activity against <italic>Staphylococcus aureu</italic>s <italic>in vivo</italic>.
Marine sponge-derived fungi have been proven to be a prolific source of bioactive natural products. Two new alkaloids, polonimides E (1) and D (2), butenolide derivative, eutypoid F (11), were isolated from the Beibu Gulf fungus, Penicillium sp. SCSIO 41413, together with thirteen known compounds (3-10, 12-16). Their structures determined by detailed NMR, MS spectroscopic analyses, electronic circular dichroism (ECD) analyses. Butenolide derivatives 11 12 exhibited inhibitory effect against...
Four new ruthenium(II) polypyridine complexes bearing 18β-glycyrrhetinic acid derivatives, [Ru(bpy)2L](PF6)2 (Ru1), [Ru(dmb)2L](PF6)2 (Ru2), [Ru(dtb)2L](PF6)2 (Ru3) and [Ru(phen)2L](PF6)2 (Ru4) (bpy = 2,2-bipyridine, dmb 4,4'-dimethyl-2,2'-bipyridine, dtb 4,4'-di-tert-butyl-2,2'-bipyridine, phen 1,10-phenanthroline L is the GA modified ligand) were designed synthesized. Their antimicrobial activities against Staphylococcus aureus (S. aureus) evaluated all showed an obvious inhibitory effect,...
Ten polyketide derivatives (1–10), including a new natural product named (E)-2,4-dihydroxy-3-methyl-6-(2-oxopent-3-en-1-yl) benzaldehyde (1), and five known diketopiperazines (11–15), were isolated from the mangrove-sediment-derived fungus Aspergillus sp. SCSIO41407. The structures of 1–15 determined via NMR MS spectroscopic analysis. In variety bioactivity screening, 3 showed weak cytotoxicity against A549 cell line, 2 exhibited antibacterial activity methicillin-resistant Staphylococcus...