A5089912317- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Seaweed-derived Bioactive Compounds
- Fungal Biology and Applications
- Genomics and Phylogenetic Studies
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Microbial Community Ecology and Physiology
- Crystallography and molecular interactions
- Probiotics and Fermented Foods
- Plant Pathogens and Fungal Diseases
- Enzyme Production and Characterization
- Microbial Metabolic Engineering and Bioproduction
- Microbial Metabolism and Applications
- Gut microbiota and health
- Chemical synthesis and alkaloids
- Bacteriophages and microbial interactions
- Aquaculture disease management and microbiota
- Synthesis and Biological Activity
- Bacterial Genetics and Biotechnology
- Bone Metabolism and Diseases
- Antimicrobial Peptides and Activities
- Cancer Mechanisms and Therapy
- Echinoderm biology and ecology
- Antifungal resistance and susceptibility
Guangxi University
2019-2025
Guangxi University of Chinese Medicine
2019-2025
This study was conducted to investigate the prebiotic potential of Chlorella pyrenoidosa polysaccharides provide useful information for developing C. as a green healthy food. were prepared and their physicochemical characteristics determined. The digestibility fermentation evaluated using in vitro models. results revealed that composed five non-starch polysaccharide fractions with monosaccharide compositions Man, Rib, Rha, GlcA, Glc, Gal, Xyl Ara. could not be degraded under saliva...
Human dihydroorotate dehydrogenase (hDHODH) is an attractive tumor target essential to de novo pyrimidine biosynthesis. Novel potent hDHODH inhibitors with low toxicity are urgently needed. Herein, we demonstrate the isolation of 25 ascochlorin (ASC) derivatives, including 13 new ones, from coral-derived fungus Acremonium sclerotigenum, and several them showed pronounced inhibitions against triple-negative breast cancer (TNBC) cell lines, MDA-MB-231/-468. Interestingly, found that required...
Phycocyanin (PC) is a pigment-protein complex. It has been reported that PC exerts anti-colorectal cancer activities, although the underlying mechanism not fully elucidated. In present study, azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced mice were orally administrated with PC, followed by microbiota and transcriptomic analyses to investigate effects of on colitis-associated (CAC). Our results indicated ameliorated AOM/DSS induced inflammation. treatment significantly reduced number...
One new depsidone derivative, aspergillusidone H (3), along with seven known biosynthetically related chlorinated polyketides, were obtained from the Beibu Gulf coral-derived fungus Aspergillus unguis GXIMD 02505. Their structures determined by comprehensive physicochemical and spectroscopic data interpretation. Notably, X-ray crystal structure of 2 previously unknown absolute configuration 8, assigned ECD calculations, are described here for first time. Compounds 1–5, 7 8 exhibited...
An unprecedented di-seco-indole diterpenoid, peniditerpenoid A (1), and a rare N-oxide-containing indole diterpenoid derivative, B (2), together with three known ones (3–5), were obtained from the mangrove-sediment-derived fungus Penicillium sp. SCSIO 41411. Their structures determined by analysis of spectroscopic data, quantum chemical calculations, X-ray diffraction analyses. Peniditerpenoid (1) inhibited lipopolysaccharide-induced NF-κB an IC50 value 11 μM further effectively prevented...
Mangrove-derived actinomycetes represent a rich source of novel bioactive natural products in drug discovery. In this study, four new polyene macrolide antibiotics antifungalmycin B-E (
A strategy integrating in silico molecular docking with LXRα and phenotypic assays was adopted to discover anti-hypercholesterolemia agents a small library containing 205 marine microorganism-derived natural products, collected by our group recent years. Two fumitremorgin derivatives, 12R,13S-dihydroxyfumitremorgin C (1) tryprostatin (3), were identified as potential agonists, real-time qPCR Western blot (WB) analysis, together surface plasmon resonance (SPR) assay. The...
A new hydrindane derivative, asperhydrindane (1), along with two known sterol analogues [isocyathisterol (2) and ganodermasides D (3)] were isolated from the mangrove-derived fungus Aspergillus terreus GXIMD 03158 attaching to mangrove Acanthus ilicifoius L. The structure of 1 was elucidated based on extensive spectral analysis, HRESIMS, calculated ECD methods. All compounds evaluated for antibacterial activity. result showed that only compound 3 exhibited significant activity against...
Two new nor‐rubrofusarin derivatives (trichsimins A and B, 1 2) one chromone derivative (trichsimin C, 5) were isolated from the deep‐sea‐derived Trichoderma simmonsii ZEN3 along with 20 known compounds (3, 4, 6−23). The structures of established by detailed analyses NMR, HRESIMS, ORD data. Nafuredin (14) exhibited potent inhibition against RSL3 induced ferroptosis EC50 value 5.54 μM.
Talaromyces marneffei (TM) is an opportunistic pathogenic fungus that mainly infects immunocompromised patients. Currently, the global prevalence of talaromycosis caused by TM increasing, leading to increased demand for anti-TM drugs. In our previous study, a novel 28-membered macrolide compound, antifungalmycin B (ANB), was isolated from Streptomyces hiroshimensis GXIMD 06359, exhibiting significant antifungal properties. However, its in vivo mechanisms and direct effects warrant further...
Laminaria japonica is widely consumed as a key food and medicine. Polysaccharides are one of the most plentiful constituents this marine plant. In study, several polysaccharide fractions with different charge numbers were obtained. Their physicochemical properties anticoagulant activities determined by chemical instrumental methods. The analysis showed that polysaccharides (LJPs) purified LJP0, LJP04, LJP06, LJP08 mainly consisted mannose, glucuronic acid, galactose, fucose in mole ratios....
Seven new 18-residue peptaibols, trichorzins A–G (1–7), were isolated from the sponge-derived fungus Trichoderma sp. GXIMD 01001. Their structures and configurations characterized by a comprehensive interpretation of NMR spectroscopic data, MS/MS fragmentation, Marfey's method, ECD analysis. The general sequences are as follows: Ac-Aib1-Ala/Ser2-Ala3-Aib/Iva4-Iva5-Gln6-Aib/Iva7-Val/allo-Ile8-Aib9-Gly10-Leu11-Aib12-Pro13-Leu14-Aib15-Aib16-Gln17-Trpol/Pheol18. obtained compounds assessed for...
Four new cyclic pentapeptides, avellanins D–G (1–4), together with four known compounds (5–8), were isolated from a mangrove-derived Aspergillus fumigatus GXIMD 03099 fungus Acanthus ilicifolius L. Their structures elucidated by analysis of HRESIMS, NMR, and ESI-MS/MS data. absolute configurations determined X-ray diffraction Marfey’s method. Compounds 1–8 screened for insecticidal antibacterial activities. Compound 2 showed activity against newly hatched larvae Culex quinquefasciatus an...
Cytochalasans have continuously aroused considerable attention among the chemistry and pharmacology communities due to their structural complexities pharmacological significances. Sixteen structurally diverse chaetoglobosins, 10-(indol-3-yl)-[13]cytochalasans, including a new one, 6-O-methyl-chaetoglobosin Q (1), were isolated from coral-associated fungus Chaetomium globosum C2F17. Their structures accomplished by extensive spectroscopic analysis combined with single-crystal X-ray...
Lactobacillus fermentum can exert antiaging effects, but their roles are strain-specific, and little is known about the molecular mechanisms in some strains. This study investigated effects of L. WC2020 (WC2020) isolated from Chinese fermented pickles underlying mechanism action Caenorhabditis elegans. enhanced mean lifespan L1-stage L4-stage worms by 22.67% 12.42%, respectively, compared with Escherichia coli OP50 (OP50), a standard food source for C. WC2020-induced longevity was...
This study investigated the impacts of salinity stress on physiological behavior, respiratory metabolism, and transcriptome artificially cultured juvenile Stichopus monotuberculatus (S. monotuberculatus) (with a body weight 3.23 ± 0.60 g). S. individuals in artificial seawater were transferred to with salinities 20‰, 30‰, 40‰ for treatment. The behavior was observed, their ammonia discharge rates, oxygen consumption oxygen/nitrogen (O/N) ratios measured. After 24 h stress, intestines...
Coral-derived microorganisms have been historically proven to be prolific sources of bioactive secondary metabolites. Twelve benzopyranone and/or xanthone derivatives, including a new with an uncommon carboxyl group at C-8, coniochaetone K (1), were obtained from the Beibu Gulf-derived coral symbiotic fungus Cladosporium halotolerans GXIMD 02502. Their structures determined by extensive spectroscopic data interpretation and comparison literature values. The absolute configuration 1 was...