A5079598353- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Genomics and Phylogenetic Studies
- Seaweed-derived Bioactive Compounds
- Protein Hydrolysis and Bioactive Peptides
- Microbial Community Ecology and Physiology
- Chemical Synthesis and Analysis
- Plant Pathogens and Fungal Diseases
- Marine Biology and Environmental Chemistry
- Bacteriophages and microbial interactions
- Antifungal resistance and susceptibility
- Biochemical and Structural Characterization
- Fungal Biology and Applications
- Cancer Mechanisms and Therapy
- Enzyme Production and Characterization
- Synthetic Organic Chemistry Methods
- Aquatic life and conservation
- Antimicrobial Peptides and Activities
- Studies on Chitinases and Chitosanases
- Phytochemical compounds biological activities
- Medicinal Plant Research
- Biological Research and Disease Studies
- Bioactive Compounds and Antitumor Agents
- Synthesis and Biological Activity
- Coral and Marine Ecosystems Studies
Guangxi University
2015-2025
Guangxi University of Chinese Medicine
2016-2025
Guangxi Medicinal Botanical Garden
2020
Jinan University
2020
University of Macau
2019
Guangxi Academy of Sciences
2017
University of Bath
2016
South China Botanical Garden
2013
South China Sea Institute Of Oceanology
2011
Institute of Oceanology
2011
Mangrove-derived actinomycetes represent a rich source of novel bioactive natural products in drug discovery. In this study, four new polyene macrolide antibiotics antifungalmycin B-E (
A strategy integrating in silico molecular docking with LXRα and phenotypic assays was adopted to discover anti-hypercholesterolemia agents a small library containing 205 marine microorganism-derived natural products, collected by our group recent years. Two fumitremorgin derivatives, 12R,13S-dihydroxyfumitremorgin C (1) tryprostatin (3), were identified as potential agonists, real-time qPCR Western blot (WB) analysis, together surface plasmon resonance (SPR) assay. The...
A new hydrindane derivative, asperhydrindane (1), along with two known sterol analogues [isocyathisterol (2) and ganodermasides D (3)] were isolated from the mangrove-derived fungus Aspergillus terreus GXIMD 03158 attaching to mangrove Acanthus ilicifoius L. The structure of 1 was elucidated based on extensive spectral analysis, HRESIMS, calculated ECD methods. All compounds evaluated for antibacterial activity. result showed that only compound 3 exhibited significant activity against...
Talaromyces marneffei (TM) is an opportunistic pathogenic fungus that mainly infects immunocompromised patients. Currently, the global prevalence of talaromycosis caused by TM increasing, leading to increased demand for anti-TM drugs. In our previous study, a novel 28-membered macrolide compound, antifungalmycin B (ANB), was isolated from Streptomyces hiroshimensis GXIMD 06359, exhibiting significant antifungal properties. However, its in vivo mechanisms and direct effects warrant further...
Four new cyclic pentapeptides, avellanins D–G (1–4), together with four known compounds (5–8), were isolated from a mangrove-derived Aspergillus fumigatus GXIMD 03099 fungus Acanthus ilicifolius L. Their structures elucidated by analysis of HRESIMS, NMR, and ESI-MS/MS data. absolute configurations determined X-ray diffraction Marfey’s method. Compounds 1–8 screened for insecticidal antibacterial activities. Compound 2 showed activity against newly hatched larvae Culex quinquefasciatus an...
In the present study, an oligosaccharide SPO-1 from Spirulina platensis was prepared by glycosidase a marine bacterium. The prebiotic activity of on growth Lactobacillus paracasei and Bifidobacterium animalis, its effect human gut microbiota were examined in vitro. molecular weight tetrasaccharide 650.2 Da, it mainly composed glucose with α-type glycosidic linkages. score highest for probiotic strains L. B. animalis. Furthermore, as fermentation proceeded, gradually degraded utilized...
Four new cyclohexylideneacetonitrile derivatives 1-4, named menisdaurins B-E, as well three known derivatives--menisdaurin (5), coclauril (6), and menisdaurilide (7)--were isolated from the hypocotyl of a mangrove (Bruguiera gymnorrhiza). The structures isolates were elucidated on basis extensive spectroscopic analysis. Compounds 1-7 showed anti-Hepatitis B virus (HBV) activities, with EC50 values ranging 5.1 ± 0.2 μg/mL to 87.7 5.8 μg/mL.
Aging is related to the lowered overall functioning and increased risk for various age-related diseases in humans. Sonneradon A (SDA), a new compound first extracted from edible fruits of mangrove Sonneratia apetala, showed remarkable antiaging activity. However, role SDA remains unclear. In this article, we studied function by using animal model Caenorhabditis elegans. Results that inhibited production reactive oxygen species (ROS) 53%, reduced accumulation aging markers such as lipids...
This study aims to investigate the anti-fatigue effect and mechanism of Syngnathus schlegeli peptides (SAP) on exercise-fatigued mice. Compared control group, SAP significantly reduced accumulation metabolites LA, BUN MDA, increased GSH-PX activity, inhibited oxidative stress, improved grip strength prolonged swimming time in Additionally, enhanced activity CS, α-KGDHC, MRCC I IV, Ca2+-Mg2+-ATPase Na+-K+-ATPase gastrocnemius muscle, thereby improving mitochondrial function increasing ATP...
Further chemical investigation of the fruits mangrove, Avicennia marina, afforded three new phenylethyl glycosides, marinoids J–L (1–3), and a cinnamoyl glycoside, marinoid M (4). The structures isolates were elucidated on basis extensive spectroscopic analysis by comparison data with those related secondary metabolites. antioxidant activity was evaluated using cellular assay (CAA), compounds 1–4 showed activities, EC50 values ranging from 23.0 ± 0.71 μM to 247.8 2.47 μM.
Vicenistatin (1) is a potent polyketide antitumor antibiotic composed of 20-membered macrolactam core appended to unique aminosugar, vicenisamine. In this study, vicenistatin was isolated and its biosynthetic gene cluster identified from Monodonata labio-associated Streptomyces parvus SCSIO Mla-L010. A set five genes, vicC, vicD, vicE, vicF, vicG, confirmed be involved in the biosynthesis aminosugar by inactivations. VicG characterized as an N-methyltransferase that catalyzes methylation...
Sugarcane smut, caused by Sporisorium scitamineum, is one of the most devastating fungal diseases affecting sugarcane worldwide. To develop a potent smut fungicide, secondary metabolites marine-derived Bacillus siamensis were isolated and screened for inhibitory activities, which led to discovery five new 24-membered macrolactins, bamemacrolactins A-E (1–5), with 3 being inhibitor. The antifungal mechanism was studied assessing its effects on mycelial morphology cell wall. Differential...
One new cyclic heptapeptide, cadophorin C (
Abstract Aims The present study aims to investigate the in vitro antifungal activity and mechanism of action bamemacrolactine C (BAC), a new 24-membered macrolide compound, against Talaromyces marneffei. Methods results test drug BAC initially demonstrated through paper disk diffusion assay, followed by determination minimum inhibitory concentration value 35.29 μg ml−1 using microdilution. association revealed that combination therapy exhibited additive effects (0.5 < FICI 1.0) when...
A Gram-stain-positive, aerobic, non-spore-forming, atrichous and short rod-shaped endophytic actinomycete, designated strain BGMRC 2075T, was isolated from the leaves of Kandelia candel, subjected to polyphasic characterization unravel its taxonomic position. Phylogenetic analyses based on 16S rRNA gene sequences indicated that 2075T belongs genus Nocardioides ,showing highest sequence similarity aestuarii JC2056T (96.1 %), agariphilus MSL-28T (95.1 %) andNocardioides islandiensis MSL-26T...
Abstract Further chemical investigation of the fruit mangrove Avicennia marina led to isolation a new caffeic acid derivative, maricaffeolylide A ( 1 ), and megastigmane maricyclohexene 2 ). The structures isolates were elucidated on basis extensive spectroscopic analysis. antioxidant activity was also evaluated using cellular assay, catechol showed with an EC 50 value 24 ± 0.3 μm.
Context Fruit of Avicennia marina (Forsk.) Vierh. (Acanthaceae) is used as a Chinese herb. Studies have found that it contains marinoid J, novel phenylethanoid glycoside (PG) compound, but its neuroprotective functions are largely unknown.Objective This study evaluated the effects J on vascular dementia (VD) and determined potential mechanisms action.Materials methods The VD model was established by ligation bilateral common carotid artery in Sprague–Dawley rats, who received daily...
Tachypleus tridentatus (T. tridentatus) is a marine animal and traditional Chinese medicine. T. plasma valuable resource for important medical health-based functions. In this experiment, in order to evaluate the effect mechanism of with respect promotion bone tissue growth rats, processes ultrafiltration mass spectrometry were first used separate identify components plasma. Then, comparison effects samples, which each possessed different molecular weights, regarding long bones rats was...