A5029697163- Mangiferin and Mango Extracts
- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Studies
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Chromatography in Natural Products
- Plant-based Medicinal Research
- Phytochemistry and Biological Activities
- Natural Antidiabetic Agents Studies
- Medicinal Plant Pharmacodynamics Research
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Mechanisms and Therapy
- Metabolomics and Mass Spectrometry Studies
- Ginger and Zingiberaceae research
- Flavonoids in Medical Research
- Medicinal Plants and Bioactive Compounds
- Tea Polyphenols and Effects
- Computational Drug Discovery Methods
- Atherosclerosis and Cardiovascular Diseases
- Genomics, phytochemicals, and oxidative stress
- Bioactive Compounds and Antitumor Agents
- Lipid metabolism and disorders
- Seaweed-derived Bioactive Compounds
- Neurological Disease Mechanisms and Treatments
- Natural Products and Biological Research
Guangxi University
2016-2025
Guangxi University of Chinese Medicine
2016-2025
Guangxi Medicinal Botanical Garden
2020
Guangxi Medical University
2013-2017
National Research Institute of Brewing
2016
Shandong University of Traditional Chinese Medicine
2012
Affiliated Hospital of Jiangxi College of TCM
2009
First Affiliated Hospital of Sichuan Medical University
2008
ABSTRACT Background Excessive lipogenesis of the skin triggers some dermatological concerns, such as enlarged pores, acne, and blackheads. Although topical drug treatments can offer temporary relief, their prolonged usage may lead to side effects dryness, irritation, or allergic reactions. Consequently, development safer efficacious ingredients in cosmetics for managing sebum overproduction represents a significant yet challenging endeavor. Aim Saponins were extracted from tea ( Camellia...
Mangiferin is a major bioactive ingredient in Mangifera indica Linn. (Anacardiaceae) leaves. Aqueous extract of such leaves have been used as an indigenous remedy for respiratory diseases like asthma and coughing traditional Chinese medicine. However, underlying molecular mechanisms mangiferin on anti-asthma remain unclear. In our present study, we investigated the anti-asthmatic effect Th1/Th2 cytokine profiles explored its immunoregulatory mechanism mouse model allergic asthma....
Chlorogenic acid (CGA) is the primary constituent of Caulis Lonicerae, a Chinese herb used for treatment rheumatoid arthritis (RA). The present study aimed to investigate whether CGA was able inhibit proliferation fibroblast-like synoviocyte cell line (RSC‑364), stimulated by interleukin (IL)-6, through inducing apoptosis. Following incubation with IL-6 or and CGA, cellular RSC‑364 cells detected MTT assay. ratio apoptosed were flow cytometry. Western blot analysis performed observe protein...
Abstract COVID-19, the disease caused by SARS-CoV-2 (1), was declared a pandemic World Health Organization (WHO) in March 2020 (2). While awaiting vaccine, several antivirals are being used to manage with limited success (3, 4). To expand this arsenal, we screened 4 compound libraries: United States Food and Drug Administration (FDA) approved drug library, an angiotensin converting enzyme-2 (ACE2) targeted flavonoid library as well natural product library. Of 121 compounds identified...
The brain-derived neurotrophic factor/tropomyosin receptor kinase B/cAMP response element-binding protein (BDNF/TrkB/CREB) signaling pathway is a critical therapeutic target for inducing adult hippocampal neurogenesis and antidepressant therapy. In this study, we tested the hypothesis that naringin, natural medicinal compound, could promote improve depression-like behaviors via regulating BDNF/TrkB/CREB pathway. We first investigated effects of naringin on promoting in both normal chronic...
Abstract Litchi ( chinensisSonnnerat, Sapindaceae ), known as Chinese Cherry, is a subtropical fruit tree originating from southern China. seed extracts have diverse pharmacological effects, including anticancer. However, its anticancer effects and mechanisms on prostate cancer not been determined. In this study, we used n-butyl alcohol extract of (NLS) to treat PC3, DU145, RM1 C4-2B cells. NLS induced significant decrease in cell viability clonogenic growth dose-dependent manner. apoptosis...
Abstract Momordica cochinchinensis (Lour.) Spreng is an indigenous South Asian edible fruit, and seeds of have been used therapeutically in traditional Chinese medicine. Previous studies shown that M. seed (Momordicae Semen) has various pharmaceutical properties such as antioxidant anti‐ulcer effects well contains secondary metabolites with potential anticancer activities triterpenoids saponins. Recent reported water extract ethanol cochinchinensi were tested on mammals using acute toxic...
Context: Chlorogenic acid (CGA) and luteolin (Lut) are the predominant constituents of Caulis Lonicerae, which is usually used in treatment for rheumatoid arthritis (RA).Objective: In this study, we investigated whether CGA Lut could synergistically inhibit proliferation fibroblast-like synoviocytes (FLSs) RA synovial tissues.Methods: Rat FLS cells (RSC-364) induced by interleukin (IL)-1β were treated CGA, or both them. The apoptosis rates detected flow cytometer. Protein expression key...
Mangiferin, which is a C‑glucosylxanthone (1,3,6,7-tetrahydroxyxanthone-C2-β-D-glucoside) purified from plant sources, has recently gained attention due to its various biological activities. The present study aimed determine the apoptotic effects of mangiferin on A549 human lung adenocarcinoma cells. In vitro studies demonstrated that exerted growth‑inhibitory and apoptosis-inducing against addition, exhibited anti-tumor properties in xenograft mice vivo. Mangiferin triggered G2/M phase cell...
Context Although the roots and stems of Kadsura coccinea (Lem.) A. C. Smith. [Schisandraceae] are herbs traditional foods in Li nationality, its toxicity remains unclear.Objective To study developmental K. consumption explain underlying mechanisms.Materials methods Zebrafish were applied to assess LC50 values hydroethanol extract (KCH) water (KCW) coccinea. In further study, three concentrations groups KCH (3.75, 7.5 15 μg/mL for embryo, 7.5, 30 larvae) control group (n = 30) administered....
Colon cancer is the third most common in world with a high mortality rate. At present, surgery combined radiotherapy and chemotherapy primary treatment, but patient prognosis remains poor. Traditional Chinese medicine (TCM) has become complementary alternative source of anti-cancer drugs. Camellia nitidissima Chi (CNC) TCM used to treat variety cancers. However, role CNC elusive, its effect mechanism on colon have not been reported. Here, we show that exerts an excellent inhibitory...
Background Camellia nitidissima var. phaeopubisperma is a variety in the section Chrysantha of genus family Theaceae which native to Fangchenggang, Guangxi, China. To date, genetic diversity and structure this remains be understood. Methods In present study, eight simple sequence repeat (SSR) molecular markers previously screened were used analyze C. natural populations from 14 growing areas China, so as determine influence environmental changes on variations provide basis for introduction...
Background: Gastrointestinal motility disorder (GMD) is a common condition characterized by dysfunction or degeneration of the myenteric plexus in specific segments gastrointestinal tract. Liupao tea (LPT) post-fermented that rich various secondary metabolites and has demonstrated range pharmacological effects, including lipid-lowering properties, antioxidant activity, modulation gut microbiota. However, underlying mechanisms which LPT improves GMD remain poorly understood. Methods: Blood...
Chlorogenic acid (CGA), a bioactive component in the human diet, is reported to exert beneficial effects on regulation of glucose metabolism. This study was designed investigate specific target CGA, and explore its underlying mechanisms. Beneficial CGA metabolism were confirmed insulin-treated hepatocarcinoma HepG2 cells. Protein fishing, via CGA-modified functionalized magnetic microspheres, demonstrated binding with protein kinase B (AKT). Immunofluorescence using molecular probe further...
Gomisin M2 isolated from Schisandra viridis A. C. Smith has potential anti-tumor effects on certain cancers, including breast cancer. However, only a few investigations have been conducted the of cancer stem cells (CSCs), which ability to self-renew and differentiate, as possible strategy resolve cell resistance apoptosis improve treatments. It is essential investigate (BCSCs). In this study, we enriched with CD44+/CD24- MDA-MB-231 HCC1806 through magnetic-activated sorting cultured these in...