A5100373242- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Immune cells in cancer
- Ovarian cancer diagnosis and treatment
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Vitamin D Research Studies
- Galectins and Cancer Biology
- Immunodeficiency and Autoimmune Disorders
- Chronic Myeloid Leukemia Treatments
- Endometriosis Research and Treatment
- Cytokine Signaling Pathways and Interactions
- Ovarian function and disorders
- Ferroptosis and cancer prognosis
- interferon and immune responses
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Metabolism, Diabetes, and Cancer
- Invertebrate Immune Response Mechanisms
- Calcium signaling and nucleotide metabolism
- Genomics, phytochemicals, and oxidative stress
Zhejiang University of Science and Technology
2025
Shenzhen Second People's Hospital
2025
Guangxi University of Chinese Medicine
2024
Dana-Farber Cancer Institute
2011-2024
Tianjin Medical University Cancer Institute and Hospital
2024
National Clinical Research
2024
Guangxi Medical University
2013-2024
Chongqing University of Arts and Sciences
2022-2024
Harvard University
2012-2024
Affiliated Hospital of Shaanxi University of Chinese Medicine
2022-2023
Waldenström's macroglobulinemia is an incurable, IgM-secreting lymphoplasmacytic lymphoma (LPL). The underlying mutation in this disorder has not been delineated.We performed whole-genome sequencing of bone marrow LPL cells 30 patients with macroglobulinemia, paired normal-tissue and tumor-tissue 10 patients. Sanger was used to validate the findings samples from expanded cohort LPL, those other B-cell disorders that have some same features as healthy donors.Among a somatic variant (T→C)...
Histone acetylation is one of the vital reversible modifications chromatin structure that regulates gene expression in eukaryotes. acetyltransferases (HATs) and histone deacetylases (HDACs) maintain homeostasis acetylation. Studies Arabidopsis have revealed HATs are involved plant responses to various stresses including light, temperature, salt ABA. Drought stress, a very common environmental could cause range physiological biochemical plants involving HATs. Eight four different families...
Abstract Fas/FasL system has been extensively investigated with respect to its capacity induce cellular apoptosis. However, accumulated evidences show that Fas signaling also exhibits nonapoptotic functions, such as induction of cell proliferation and differentiation. Lung cancer is one cancer’s refractory the immunotherapy, however, underlying mechanisms remain be fully understood. In this study, we overexpression does not affect in vitro growth 3LL cells, but promotes lung vivo....
Abstract Litchi ( chinensisSonnnerat, Sapindaceae ), known as Chinese Cherry, is a subtropical fruit tree originating from southern China. seed extracts have diverse pharmacological effects, including anticancer. However, its anticancer effects and mechanisms on prostate cancer not been determined. In this study, we used n-butyl alcohol extract of (NLS) to treat PC3, DU145, RM1 C4-2B cells. NLS induced significant decrease in cell viability clonogenic growth dose-dependent manner. apoptosis...
It has been reported that diet and nutrition play important roles in the occurrence development of hepatocellular carcinoma (HCC). In this study, we investigated potential tumor-promoting mechanisms a high-fat (HFD) mice with dietondiethylnitrosamine (DEN)-induced hepatocarcinogenesis. HFD significantly decreased survival rate induced severe liver dysfunction DEN-induced mice, as indicated by increased serum glutamic-pyruvic transaminase (ALT), glutamic oxalacetic (AST), alkaline phosphatase...
Colorectal cancer (CRC) is a prevalent and highly lethal malignancy, with current therapeutic efficacy limited by the tumor's high invasiveness metastatic potential. Matrix metalloproteinases (MMPs) WNT (Wingless/Integrated) signaling pathway play key roles in invasion metastasis of CRC. Salidroside, natural compound, has demonstrated inhibitory effects several cancers, but its precise molecular mechanism CRC cells remains unclear. This study aims to investigate antitumor effect salidroside...
Ovarian cancer is the most lethal of female reproductive system. There a consistent and urgent need to better understand its mechanism. In this study, we retrieved 186 genes that were dysregulated by at least 4-fold in 594 ovarian serous cystadenocarcinomas comparison with eight normal ovaries, according The Cancer Genome Atlas Statistics data deposited Oncomine database. DAVID analysis these enriched two biological processes indicating cell cycle microtubules might play critical roles...
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths. The average survival and 5-year rates HCC patients still remains poor. Thus, there an urgent need to better understand mechanisms cancer progression in identify useful biomarkers predict prognosis. Public data portals including Oncomine, Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) profiles were used retrieve HCC-related microarrays potential genes contributed progression. Bioinformatics analyses...
Abstract The outcome for patients with ovarian cancer (OC) is poor because of drug resistance. Therefore, identification factors that affect resistance and prognosis in OC needed. In the present study, we identified 131 genes significantly dysregulated 90 platinum‐resistant tissues compared 197 sensitive tissues, which 30 were associated disease‐free survival (DFS; n = 16), overall (OS; 6), or both (n 8) 489 Cancer Genome Atlas cohort. Of these genes, 17 upregulated 13 downregulated...